> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/jak3-be0452ac-5f65-592e-9b95-3663e6d8709b > Record changed: 2026-10-13 # JAK3 ENSG00000105639 Target class Kinase Chromosome 19 Approved drugs 8 Clinical candidates (approved and in development) 19 ## Clinical evidence **Approved drugs** 8 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 19 ## Druggability **Chemical probe available** Yes ## Names **Target name** JAK3 **Gene name** Janus kinase 3 **Gene symbol** JAK3 **Protein name** Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) ### Other names (5) - L-JAK - JAKL - LJAK - JAK3\_HUMAN - JAK-3 ## Classification **Gene biotype** Protein coding **Gene family** Jak family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 139.15 **Tissue specificity (Gini)** 0.64 **Tissue specificity (tau)** 0.937 ## Pathways and interactions **KEGG gene identifiers** - hsa:3718 **Protein interaction confidence** 0.84339 **Protein interaction partners** 118 ### Reactome pathways (11) - R-HSA-1266695 - R-HSA-201556 - R-HSA-5673001 - R-HSA-6785807 - R-HSA-8854691 - R-HSA-8983432 - R-HSA-8985947 - R-HSA-9020558 - R-HSA-9020958 - R-HSA-912526 - R-HSA-9679191 ## Genomic location **End position** 17848071 **Start position** 17824780 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000105639 **HGNC ID** HGNC:6193 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6193) **NCBI Gene ID** 3718 **UniProt ID** P52333 ## Cellular location - Endomembrane system - Peripheral membrane protein . Cytoplasm . - Cytosol - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.936924 **Expression inequality (Gini)** 0.640065 ### Highest expression Expression in transcripts per million **Whole Blood** 139.15 **Spleen** 108.55 **Cells - EBV-transformed lymphocytes** 41.99 **Ovary** 39.16 **Lung** 27.5 ### All tissues (54) Expression in transcripts per million - Whole Blood139.15 - Spleen108.55 - Cells - EBV-transformed lymphocytes41.99 - Ovary39.16 - Lung27.5 - Small Intestine - Terminal Ileum16.01 - Fallopian Tube13.01 - Cervix - Endocervix11.18 - Adipose - Visceral (Omentum)10.88 - Thyroid9.54 - Prostate8.95 - Breast - Mammary Tissue7.99 - Kidney - Medulla7.83 - Adipose - Subcutaneous7.41 - Artery - Coronary7.15 - Testis6.77 - Bladder6.69 - Brain - Cerebellum6.4 - Nerve - Tibial6.19 - Minor Salivary Gland6.17 - Pituitary6.07 - Vagina5.95 - Brain - Cerebellar Hemisphere5.9 - Colon - Transverse5.36 - Brain - Hypothalamus5.32 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (14) - GO:0007260 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007260) - GO:0035723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035723) - GO:0035771 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035771) - GO:0038110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038110) - GO:0038111 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038111) - GO:0038113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038113) - GO:0043029 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043029) - GO:0046425 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046425) - GO:0060397 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060397) - GO:0070669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070669) - GO:0070670 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070670) - GO:0070672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070672) - GO:0071104 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071104) - GO:2000329 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000329) ### Cellular components (6) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009898) - GO:0019897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019897) - GO:0031234 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031234) ### Molecular functions (3) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019903) ## Related records ### Trials (508) - 24-week Study With Open Label Extension of VX-509, an Oral JAK3 Inhibitor, in Subjects Taking Methotrexate - 3T Therapy in the Treatment of MDA5-positive Dermatomyositis - [A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2](https://trialight.com/data/trial/a-104-week-study-of-ritlecitinib-oral-capsules-in-adults-ff919ca0-6ace-45c1-b983-750c0c3cc811.md) - A 12 Day Study To Evaluate A Topical Drug To Treat Plaque Psoriasis - A 12-week Study of 4 Doses of VX-509 in Subjects With Active Rheumatoid Arthritis - A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS. - A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis - A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate - A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema - A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents With Nonsegmental Vitiligo (Active and Stable) Tranquillo - A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo - A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus - A 6-Month Study Of CP-690,550 Versus Tacrolimus In Kidney Transplant Patients - A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis - A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Metformin - A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid Arthritis - A DRUG-DRUG INTERACTION STUDY BETWEEN PF-06650833 AND PF-06651600 FOLLOWING MULTIPLE DOSES IN HEALTHY PARTICIPANTS - A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis - A Long Term Study To Evaluate The Safety, Tolerability And Efficacy Of CP-690,550 In Patients With Moderate To Severe Plaque Psoriasis And/Or Psoriatic Arthritis - A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata. ### Drugs (22) - AT-9283 Tyrosine-protein kinase JAK3 inhibitor - Cerdulatinib Tyrosine-protein kinase JAK3 inhibitor - Decernotinib Tyrosine-protein kinase JAK3 inhibitor - Delgocitinib Janus Kinase (JAK) inhibitor - Deuruxolitinib phosphate Tyrosine-protein kinase JAK3 inhibitor - Filgotinib Tyrosine-protein kinase JAK3 inhibitor - Filgotinib maleate Tyrosine-protein kinase JAK3 inhibitor - Gusacitinib Janus Kinase (JAK) inhibitor - Izencitinib Janus Kinase (JAK) inhibitor - Nezulcitinib Janus Kinase (JAK) inhibitor - Peficitinib Janus Kinase (JAK) inhibitor - R-333 Tyrosine-protein kinase JAK3 inhibitor - R-348 Tyrosine-protein kinase JAK3 inhibitor - [Ritlecitinib](https://trialight.com/data/asset/ritlecitinib-4c942dd0-fc10-47f2-85c8-213af4721107.md) Tyrosine-protein kinase JAK3 inhibitor - Ritlecitinib tosylate Tyrosine-protein kinase JAK3 inhibitor - [Ruxolitinib](https://trialight.com/data/asset/ruxolitinib-3ab34d42-3776-4160-9bc2-d149204acfd5.md) Tyrosine-protein kinase JAK3 inhibitor - Tofacitinib Janus Kinase (JAK) inhibitor - Tofacitinib citrate Janus Kinase (JAK) inhibitor - Tricetamide Tyrosine-protein kinase JAK3 inhibitor - Upadacitinib Tyrosine-protein kinase JAK3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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