> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/jak2-6d06f09e-903b-5a13-9d7a-79efa991190f > Record changed: 2026-10-13 # JAK2 ENSG00000096968 Target class Kinase Chromosome 9 Approved drugs 14 Clinical candidates (approved and in development) 29 ## Clinical evidence **Approved drugs** 14 **Clinical candidates (approved and in development)** 29 ## Druggability **Chemical probe available** Yes ## Names **Other names** - JTK10 **Target name** JAK2 **Gene name** Janus kinase 2 **Gene symbol** JAK2 **Protein name** Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing|FERM domain containing|Jak family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 68.89 **Tissue specificity (Gini)** 0.434 **Tissue specificity (tau)** 0.846 ## Pathways and interactions **KEGG gene identifiers** - hsa:3717 **Protein interaction confidence** 0.873976 **Protein interaction partners** 207 ### Reactome pathways (39) - R-HSA-1059683 - R-HSA-110056 - R-HSA-112411 - R-HSA-1170546 - R-HSA-1433557 - R-HSA-2586552 - R-HSA-3214858 - R-HSA-512988 - R-HSA-5673000 - R-HSA-5673001 - R-HSA-6785807 - R-HSA-6788467 - R-HSA-6802946 - R-HSA-6802952 - R-HSA-6802955 - R-HSA-69231 - R-HSA-877300 - R-HSA-877312 - R-HSA-8854691 - R-HSA-8984722 - R-HSA-9006335 - R-HSA-9020591 - R-HSA-9020933 - R-HSA-9020956 - R-HSA-9027276 And 14 more, listed on the interactive page. ## Genomic location **End position** 5129948 **Start position** 4984390 **Chromosome** 9 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000096968 **HGNC ID** HGNC:6192 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6192) **NCBI Gene ID** 3717 **UniProt ID** O60674 ## Cellular location - Endomembrane system - Peripheral membrane protein . Cytoplasm . Nucleus . - Focal adhesion sites - Nucleoplasm ### Publication evidence - PubMed 19783980 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19783980/) ## Tissue expression **Tissue specificity (tau)** 0.846351 **Expression inequality (Gini)** 0.434397 ### Highest expression Expression in transcripts per million **Artery - Tibial** 68.89 **Artery - Aorta** 46.89 **Artery - Coronary** 31.65 **Adipose - Subcutaneous** 20.79 **Nerve - Tibial** 20 ### All tissues (54) Expression in transcripts per million - Artery - Tibial68.89 - Artery - Aorta46.89 - Artery - Coronary31.65 - Adipose - Subcutaneous20.79 - Nerve - Tibial20 - Lung18.99 - Skin - Sun Exposed (Lower leg)18.02 - Vagina17.78 - Cervix - Ectocervix17.51 - Uterus17.36 - Ovary17.28 - Cells - EBV-transformed lymphocytes17.13 - Skin - Not Sun Exposed (Suprapubic)16.38 - Cervix - Endocervix16.17 - Spleen15.6 - Breast - Mammary Tissue15.46 - Adipose - Visceral (Omentum)14.8 - Fallopian Tube14.62 - Bladder13.17 - Esophagus - Muscularis12.66 - Esophagus - Gastroesophageal Junction12.5 - Colon - Sigmoid11.34 - Small Intestine - Terminal Ileum11.33 - Testis11.02 - Esophagus - Mucosa9.67 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (34) - GO:0007155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0007498 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007498) - GO:0010572 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010572) - GO:0010811 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010811) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0033209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033209) - GO:0034612 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034612) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0035722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035722) - GO:0038043 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038043) - GO:0038065 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038065) - GO:0038155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038155) - GO:0038156 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038156) - GO:0038157 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038157) - GO:0038162 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038162) - GO:0038163 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038163) - GO:0038165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038165) - GO:0043687 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043687) - GO:0046677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046677) - GO:0048861 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048861) - GO:0050727 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050727) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0060333 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060333) - GO:0060391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060391) And 9 more, listed on the interactive page. ### Cellular components (9) - GO:0000785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000785) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0009898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009898) - GO:0019897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019897) - GO:0031234 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031234) - GO:0031904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031904) ### Molecular functions (9) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0020037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0020037) - GO:0035401 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035401) - GO:0042169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042169) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## On-target safety - heart disease ### Studies - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: JAK2 and STAT3 protective in many pathological settings ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hJak2, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hJak2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,095) - "Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype. - 3T Therapy in the Treatment of MDA5-positive Dermatomyositis - A 12 Day Study To Evaluate A Topical Drug To Treat Plaque Psoriasis - A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis - A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate - A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema - A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus - A 6-Month Study Of CP-690,550 Versus Tacrolimus In Kidney Transplant Patients - A Clinical Study of Ruxolitinib in Patients With Primary Myelofibrosis (PM), Post-polycythemia Vera (PV) Myelofibrosis, or Post-essential Thrombocythemia (ET) Myelofibrosis - A Clinical Study to Test the Effects of Ruxolitinib And Thalidomide Combination for Patients With Myelofibrosis - A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025) - A Clinical Trial of Flonoltinib Maleate for Intermediate or High-Risk Myelofibrosis - A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis - A Dose Ranging Study of the Effect of Ruxolitinib Phosphate Cream When Applied to Participants With Plaque Psoriasis - A Dose-escalation Study of the Safety and Tolerability of Orally Administered TG101348 in Patients With Myelofibrosis - A Drug Drug Interaction (DDI) Study of Baricitinib (LY3009104) and Digoxin in Healthy Participants - A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Metformin - A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid Arthritis - A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis - A Long Term Study To Evaluate The Safety, Tolerability And Efficacy Of CP-690,550 In Patients With Moderate To Severe Plaque Psoriasis And/Or Psoriatic Arthritis ### Drugs (32) - AC-430 Tyrosine-protein kinase JAK2 inhibitor - AT-9283 Tyrosine-protein kinase JAK2 inhibitor - AZD-1480 Tyrosine-protein kinase JAK2 inhibitor - [Baricitinib](https://trialight.com/data/asset/baricitinib-dde0cdc5-8f75-41b1-bc92-b187471c63df.md) Tyrosine-protein kinase JAK2 inhibitor - BMS-911543 Tyrosine-protein kinase JAK2 inhibitor - CT-1578 Tyrosine-protein kinase JAK2 inhibitor - Delgocitinib Janus Kinase (JAK) inhibitor - Deuruxolitinib phosphate Tyrosine-protein kinase JAK2 inhibitor - Fedratinib Tyrosine-protein kinase JAK2 inhibitor - Fedratinib hydrochloride Tyrosine-protein kinase JAK2 inhibitor - Filgotinib Tyrosine-protein kinase JAK2 inhibitor - Filgotinib maleate Tyrosine-protein kinase JAK2 inhibitor - Gandotinib Tyrosine-protein kinase JAK2 inhibitor - Gusacitinib Janus Kinase (JAK) inhibitor - Izencitinib Janus Kinase (JAK) inhibitor - Lestaurtinib Tyrosine-protein kinase JAK2 inhibitor - LS-104 Tyrosine-protein kinase JAK2 inhibitor - [Momelotinib](https://trialight.com/data/asset/momelotinib-d384d174-93c9-4c16-bc43-4bc528bdef0d.md) Tyrosine-protein kinase JAK2 inhibitor - Momelotinib dihydrochloride monohydrate Tyrosine-protein kinase JAK2 inhibitor - Nezulcitinib Janus Kinase (JAK) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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