> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/jak1-c22a6fc9-26d6-5daa-a0f4-71cd08b3c5e1 > Record changed: 2026-10-13 # JAK1 ENSG00000162434 Target class Kinase Chromosome 1 Approved drugs 11 Clinical candidates (approved and in development) 23 ## Clinical evidence **Approved drugs** 11 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 23 ## Druggability **Chemical probe available** Yes ## Names **Target name** JAK1 **Gene name** Janus kinase 1 **Gene symbol** JAK1 **Previous gene symbols** - JAK1B **Protein name** Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) ### Other names (2) - JAK1A - JTK3 ## Classification **Gene biotype** Protein coding **Gene family** FERM domain containing|Jak family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 139.9 **Tissue specificity (Gini)** 0.292 **Tissue specificity (tau)** 0.586 ## Pathways and interactions **KEGG gene identifiers** - hsa:3716 **Protein interaction confidence** 0.892741 **Protein interaction partners** 147 ### Reactome pathways (31) - R-HSA-1059683 - R-HSA-110056 - R-HSA-112411 - R-HSA-1169408 - R-HSA-1266695 - R-HSA-449836 - R-HSA-5673001 - R-HSA-6783783 - R-HSA-6785807 - R-HSA-6788467 - R-HSA-877300 - R-HSA-877312 - R-HSA-8854691 - R-HSA-8983432 - R-HSA-8984722 - R-HSA-8985947 - R-HSA-9020558 - R-HSA-9020591 - R-HSA-9020956 - R-HSA-9020958 - R-HSA-909733 - R-HSA-912526 - R-HSA-912694 - R-HSA-9674555 - R-HSA-9679191 And 6 more, listed on the interactive page. ## Genomic location **End position** 65067754 **Start position** 64833223 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000162434 **HGNC ID** HGNC:6190 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6190) **NCBI Gene ID** 3716 **UniProt ID** P23458 ## Cellular location - Endomembrane system - Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. ## Tissue expression **Tissue specificity (tau)** 0.586133 **Expression inequality (Gini)** 0.291699 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 139.9 **Adipose - Subcutaneous** 124.01 **Lung** 110.05 **Cervix - Endocervix** 107.29 **Ovary** 101.36 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts139.9 - Adipose - Subcutaneous124.01 - Lung110.05 - Cervix - Endocervix107.29 - Ovary101.36 - Adipose - Visceral (Omentum)98.95 - Artery - Tibial97.39 - Breast - Mammary Tissue97.3 - Cervix - Ectocervix95.4 - Spleen95.08 - Uterus90.81 - Skin - Sun Exposed (Lower leg)83.99 - Fallopian Tube83 - Bladder82.83 - Artery - Coronary76.18 - Thyroid75.52 - Artery - Aorta74.51 - Vagina71.7 - Small Intestine - Terminal Ileum71 - Skin - Not Sun Exposed (Suprapubic)69.94 - Nerve - Tibial68.79 - Esophagus - Gastroesophageal Junction66.76 - Colon - Sigmoid66.4 - Brain - Cerebellar Hemisphere65.69 - Esophagus - Muscularis64.69 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (23) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0034112 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034112) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0035723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035723) - GO:0035771 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035771) - GO:0038110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038110) - GO:0038111 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038111) - GO:0038113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038113) - GO:0038154 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038154) - GO:0038165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038165) - GO:0046677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046677) - GO:0048861 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048861) - GO:0060333 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060333) - GO:0060337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060337) - GO:0070102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070102) - GO:0070120 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070120) - GO:0072540 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072540) - GO:0140105 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140105) - GO:0150105 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150105) - GO:1900182 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900182) - GO:1903672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903672) ### Cellular components (9) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0009898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009898) - GO:0031234 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031234) ### Molecular functions (5) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019903) - GO:0031625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625) ## Related records ### Trials (1,162) - "Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype. - 3T Therapy in the Treatment of MDA5-positive Dermatomyositis - A 12 Day Study To Evaluate A Topical Drug To Treat Plaque Psoriasis - A 12-Week Open-Label Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Skin-Predominant Dermatomyositis - A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis - A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate - A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema - A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus - A 6-Month Study Of CP-690,550 Versus Tacrolimus In Kidney Transplant Patients - A Clinical Study of Ruxolitinib in Patients With Primary Myelofibrosis (PM), Post-polycythemia Vera (PV) Myelofibrosis, or Post-essential Thrombocythemia (ET) Myelofibrosis - A Clinical Study to Test the Effects of Ruxolitinib And Thalidomide Combination for Patients With Myelofibrosis - A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025) - A Clinical Trial of Flonoltinib Maleate for Intermediate or High-Risk Myelofibrosis - A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis - A Dose Ranging Study of the Effect of Ruxolitinib Phosphate Cream When Applied to Participants With Plaque Psoriasis - A DOSE-RANGING STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-06700841 IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) - A Drug Drug Interaction (DDI) Study of Baricitinib (LY3009104) and Digoxin in Healthy Participants - A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Metformin - A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid Arthritis - A Hepatic Impairment Study for PF-04965842. ### Drugs (26) - Abrocitinib Tyrosine-protein kinase JAK1 inhibitor - [Baricitinib](https://trialight.com/data/asset/baricitinib-dde0cdc5-8f75-41b1-bc92-b187471c63df.md) Tyrosine-protein kinase JAK1 inhibitor - Brepocitinib Tyrosine-protein kinase JAK1 inhibitor - Cerdulatinib Tyrosine-protein kinase JAK1 inhibitor - Delgocitinib Janus Kinase (JAK) inhibitor - Deuruxolitinib phosphate Tyrosine-protein kinase JAK1 inhibitor - Filgotinib Tyrosine-protein kinase JAK1 inhibitor - Filgotinib maleate Tyrosine-protein kinase JAK1 inhibitor - GLPG-0555 Tyrosine-protein kinase JAK1 inhibitor - Golidocitinib Tyrosine-protein kinase JAK1 inhibitor - Gusacitinib Janus Kinase (JAK) inhibitor - INCB-047986 Tyrosine-protein kinase JAK1 inhibitor - Itacitinib Tyrosine-protein kinase JAK1 inhibitor - Izencitinib Janus Kinase (JAK) inhibitor - [Momelotinib](https://trialight.com/data/asset/momelotinib-d384d174-93c9-4c16-bc43-4bc528bdef0d.md) Tyrosine-protein kinase JAK1 inhibitor - Momelotinib dihydrochloride monohydrate Tyrosine-protein kinase JAK1 inhibitor - Nezulcitinib Janus Kinase (JAK) inhibitor - Peficitinib Janus Kinase (JAK) inhibitor - [Ruxolitinib](https://trialight.com/data/asset/ruxolitinib-3ab34d42-3776-4160-9bc2-d149204acfd5.md) Tyrosine-protein kinase JAK1 inhibitor - [Ruxolitinib phosphate](https://trialight.com/data/asset/ruxolitinib-phosphate-fce80c56-88a2-456a-bcb5-431e98979584.md) Tyrosine-protein kinase JAK1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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