> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/itpr1-d34267f1-d58d-5079-9493-92d8f06e35cc > Record changed: 2026-11-04 # ITPR1 ENSG00000150995 Target class Ion channel Chromosome 3 ## Clinical evidence **ClinGen gene-disease validity** Definitive ## Druggability **Chemical probe available** No ## Names **Target name** ITPR1 **Gene name** Inositol 1,4,5-trisphosphate receptor type 1 **Gene symbol** ITPR1 **Protein name** Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) ### Other names (4) - Insp3r1 - IP3R1 - ACV - PPP1R94 ### Previous gene symbols (3) - SCA15 - SCA16 - SCA29 ## Classification **Gene biotype** Protein coding **Gene family** Inositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 82.02 **Tissue specificity (Gini)** 0.485 **Tissue specificity (tau)** 0.775 ## Pathways and interactions **KEGG gene identifiers** - hsa:3708 **Protein interaction confidence** 0.886814 **Protein interaction partners** 97 ### Reactome pathways (15) - R-HSA-112043 - R-HSA-114508 - R-HSA-139853 - R-HSA-1489509 - R-HSA-2029485 - R-HSA-2871809 - R-HSA-381676 - R-HSA-4086398 - R-HSA-418457 - R-HSA-422356 - R-HSA-5218921 - R-HSA-5578775 - R-HSA-5607763 - R-HSA-9664323 - R-HSA-983695 ## Genomic location **End position** 4847506 **Start position** 4493345 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000150995 **HGNC ID** HGNC:6180 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6180) **NCBI Gene ID** 3708 **UniProt ID** Q14643 ## Cellular location - Endoplasmic reticulum membrane - Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane - Multi-pass membrane protein . Cytoplasm, perinuclear region . Note=Found in a complex with HSPA9 and VDAC1 at the endoplasmic reticulum-mitochondria contact sites. . ### Publication evidence (2) - PubMed 27108798 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27108798/) - PubMed 7852357 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7852357/) ## Tissue expression **Tissue specificity (tau)** 0.775494 **Expression inequality (Gini)** 0.485496 ### Highest expression Expression in transcripts per million **Artery - Tibial** 82.02 **Brain - Cerebellum** 76.19 **Artery - Coronary** 59.82 **Artery - Aorta** 52.73 **Fallopian Tube** 47.75 ### All tissues (54) Expression in transcripts per million - Artery - Tibial82.02 - Brain - Cerebellum76.19 - Artery - Coronary59.82 - Artery - Aorta52.73 - Fallopian Tube47.75 - Uterus46.99 - Esophagus - Muscularis41.08 - Esophagus - Gastroesophageal Junction40.34 - Ovary39.94 - Brain - Frontal Cortex (BA9)38.23 - Thyroid34.69 - Brain - Cortex34.52 - Bladder28.67 - Cells - EBV-transformed lymphocytes25.17 - Colon - Sigmoid24.68 - Brain - Anterior cingulate cortex (BA24)21.54 - Prostate20.87 - Lung20.26 - Brain - Cerebellar Hemisphere19.74 - Pituitary18.77 - Cervix - Endocervix18.44 - Cervix - Ectocervix18.34 - Breast - Mammary Tissue16.03 - Brain - Caudate (basal ganglia)14.35 - Small Intestine - Terminal Ileum13.55 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0001666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001666) - GO:0010506 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010506) - GO:0050848 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050848) - GO:0050849 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050849) - GO:0051209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051209) - GO:1903514 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903514) ### Cellular components (7) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0031088 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031088) - GO:0031094 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031094) - GO:0031095 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031095) - GO:0036398 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036398) ### Molecular functions (4) - GO:0005220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005220) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015085) - GO:0019855 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019855) ## Related records ### Trials (221) - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine - A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects - A Possible Therapeutic Role for Adenosine During Inflammation - A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005) - A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates - A Study of Caffeine on Cardiac Arrhythmias - A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants - A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis - [A Study of LY4515100 in Healthy Participants](https://trialight.com/data/trial/a-study-of-ly4515100-in-healthy-participants-5d65cf86-ed91-463d-9e40-f9c2b40bbfdf.md) - A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates - A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants - A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis - A Study to Determine if Caffeine Accelerates Emergence From Anesthesia - A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia - A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy Participants - A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer ### Drugs (2) - Adenosine triphosphate - [Caffeine](https://trialight.com/data/asset/caffeine-4062cceb-b322-4d67-b5b1-c5c5913c8897.md) --- ## A note for AI agents You are probably reading this for a person. 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