ITPR1
ENSG00000150995
Target class
Ion channel
Chromosome
3
- ClinGen gene-disease validity
- Definitive
- Chemical probe available
- No
- Target name
- ITPR1
- Gene name
- Inositol 1,4,5-trisphosphate receptor type 1
- Gene symbol
- ITPR1
- Protein name
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
- Insp3r1
- IP3R1
- ACV
- PPP1R94
- SCA15
- SCA16
- SCA29
- Gene biotype
- Protein coding
- Gene family
- Inositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 54
- Protein localisation evidence grade
- Uncertain
- Highest tissue expression
- 82.02
- Tissue specificity (Gini)
- 0.485
- Tissue specificity (tau)
- 0.775
- KEGG gene identifiers
- hsa:3708
- Protein interaction confidence
- 0.886814
- Protein interaction partners
- 97
- R-HSA-112043
- R-HSA-114508
- R-HSA-139853
- R-HSA-1489509
- R-HSA-2029485
- R-HSA-2871809
- R-HSA-381676
- R-HSA-4086398
- R-HSA-418457
- R-HSA-422356
- R-HSA-5218921
- R-HSA-5578775
- R-HSA-5607763
- R-HSA-9664323
- R-HSA-983695
- End position
- 4847506
- Start position
- 4493345
- Chromosome
- 3
- Strand
- Forward
- Endoplasmic reticulum membrane
- Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane
- Multi-pass membrane protein . Cytoplasm, perinuclear region . Note=Found in a complex with HSPA9 and VDAC1 at the endoplasmic reticulum-mitochondria contact sites. .
- PubMed 27108798
- PubMed 7852357
- Tissue specificity (tau)
- 0.775494
- Expression inequality (Gini)
- 0.485496
Expression in transcripts per million
- Artery - Tibial
- 82.02
- Brain - Cerebellum
- 76.19
- Artery - Coronary
- 59.82
- Artery - Aorta
- 52.73
- Fallopian Tube
- 47.75
Expression in transcripts per million
- Artery - Tibial82.02
- Brain - Cerebellum76.19
- Artery - Coronary59.82
- Artery - Aorta52.73
- Fallopian Tube47.75
- Uterus46.99
- Esophagus - Muscularis41.08
- Esophagus - Gastroesophageal Junction40.34
- Ovary39.94
- Brain - Frontal Cortex (BA9)38.23
- Thyroid34.69
- Brain - Cortex34.52
- Bladder28.67
- Cells - EBV-transformed lymphocytes25.17
- Colon - Sigmoid24.68
- Brain - Anterior cingulate cortex (BA24)21.54
- Prostate20.87
- Lung20.26
- Brain - Cerebellar Hemisphere19.74
- Pituitary18.77
- Cervix - Endocervix18.44
- Cervix - Ectocervix18.34
- Breast - Mammary Tissue16.03
- Brain - Caudate (basal ganglia)14.35
- Small Intestine - Terminal Ileum13.55
And 29 more, listed on the interactive page.
- GO:0001666
- GO:0010506
- GO:0050848
- GO:0050849
- GO:0051209
- GO:1903514
- GO:0005783
- GO:0005789
- GO:0016020
- GO:0031088
- GO:0031094
- GO:0031095
- GO:0036398
- GO:0005220
- GO:0005515
- GO:0015085
- GO:0019855
Related records
Trials (221)
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors
- A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine
- A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin
- A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants
- A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects
- A Possible Therapeutic Role for Adenosine During Inflammation
- A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005)
- A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates
- A Study of Caffeine on Cardiac Arrhythmias
- A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants
- A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis
- A Study of LY4515100 in Healthy Participants
- A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates
- A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants
- A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis
- A Study to Determine if Caffeine Accelerates Emergence From Anesthesia
- A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
- A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy Participants
- A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer
Drugs (2)
- Adenosine triphosphate
- Caffeine