> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/itk-e8d7f08e-49be-5ca0-9157-b8d3d1890b60
> Record changed: 2026-10-13

# ITK

ENSG00000113263

Target class

Kinase

Chromosome

5

Approved drugs

3

Clinical candidates (approved and in development)

3

## Clinical evidence

**Approved drugs**

3

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

3

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

ITK

**Gene name**

IL2 inducible T cell kinase

**Gene symbol**

ITK

**Protein name**

Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)

### Other names (3)

- EMT
- PSCTK2
- LYK

## Classification

**Gene biotype**

Protein coding

**Gene family**

Pleckstrin homology domain containing|SH2 domain containing|Tec family tyrosine kinases

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

24

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

16.65

**Tissue specificity (Gini)**

0.672

**Tissue specificity (tau)**

0.917

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3702

**Protein interaction confidence**

0.869446

**Protein interaction partners**

56

### Reactome pathways (2)

- R-HSA-202433
- R-HSA-2871809

## Genomic location

**End position**

157255185

**Start position**

157142933

**Chromosome**

5

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000113263

**HGNC ID**

HGNC:6171

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6171)

**NCBI Gene ID**

3702

**UniProt ID**

Q08881

## Cellular location

- Cytoplasm . Nucleus . Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
- Cytosol

### Publication evidence

- PubMed 17060314  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17060314/)

## Tissue expression

**Tissue specificity (tau)**

0.917276

**Expression inequality (Gini)**

0.672077

### Highest expression

Expression in transcripts per million

**Spleen**

16.65

**Whole Blood**

10.52

**Small Intestine - Terminal Ileum**

10.45

**Lung**

8.9

**Adipose - Visceral (Omentum)**

3.9

### All tissues (54)

Expression in transcripts per million

- Spleen16.65
- Whole Blood10.52
- Small Intestine - Terminal Ileum10.45
- Lung8.9
- Adipose - Visceral (Omentum)3.9
- Thyroid2.19
- Adipose - Subcutaneous2.14
- Fallopian Tube2.14
- Vagina2.08
- Cervix - Ectocervix1.88
- Colon - Transverse1.83
- Cervix - Endocervix1.75
- Breast - Mammary Tissue1.73
- Stomach1.63
- Artery - Coronary1.48
- Skin - Not Sun Exposed (Suprapubic)1.46
- Prostate1.35
- Testis1.31
- Uterus1.31
- Nerve - Tibial1.25
- Artery - Aorta1.16
- Bladder1.14
- Minor Salivary Gland1.13
- Esophagus - Mucosa1.09
- Skin - Sun Exposed (Lower leg)0.96

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (3)

- GO:0006968  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006968)
- GO:0007165  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165)
- GO:0042110  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042110)

### Cellular components

- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)

### Molecular functions (2)

- GO:0004715  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (318)

- \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer
- 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD)
- [A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2](https://trialight.com/data/trial/a-104-week-study-of-ritlecitinib-oral-capsules-in-adults-ff919ca0-6ace-45c1-b983-750c0c3cc811.md)
- A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.
- A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents With Nonsegmental Vitiligo (Active and Stable) Tranquillo
- A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
- A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer
- A Combination of Pazopanib and Carboplatin in Advanced Solid Malignancies
- A DRUG-DRUG INTERACTION STUDY BETWEEN PF-06650833 AND PF-06651600 FOLLOWING MULTIPLE DOSES IN HEALTHY PARTICIPANTS
- A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata.
- A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors
- A Phase 1B Dose-escalation and Phase 2a Study of Carotuximab (TRC105) in Combination With Pazopanib in Patients With Advanced Soft Tissue Sarcoma
- A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects
- A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors
- A Phase I Study of Pazopanib in Adult Patients With Liver Cancer
- A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas
- A Phase I Study Of Pazopanib With Either Erlotinib Or Pemetrexed In Patients With Advanced Solid Tumors
- A Phase I, Open-label, Study of Pazopanib in Combination With Epirubicin or Doxorubicin for Advanced Solid Tumors
- A Phase I, Open-label, Study of Pazopanib in Combination With Gemcitabine and Gemcitabine Plus Cisplatin for Advanced Solid Tumors
- A Phase II Trial Comparing Gemcitabine and Pazopanib Versus Gemcitabine and Docetaxel for Patients With Advanced Soft Tissue Sarcoma

### Drugs (4)

- Pazopanib Tyrosine-protein kinase ITK/TSK inhibitor
- Pazopanib hydrochloride Tyrosine-protein kinase ITK/TSK inhibitor
- [Ritlecitinib](https://trialight.com/data/asset/ritlecitinib-4c942dd0-fc10-47f2-85c8-213af4721107.md) TEC family kinase inhibitor
- Ritlecitinib tosylate TEC family kinase inhibitor

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