> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/itgb3-8d05de84-876f-5d95-b273-23919b11b6a3 > Record changed: 2026-11-04 # ITGB3 ENSG00000259207 Target class Membrane receptor Chromosome 17 Approved drugs 3 Clinical candidates (approved and in development) 10 ## Clinical evidence **Approved drugs** 3 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 10 ## Druggability **Chemical probe available** Yes ## Names **Target name** ITGB3 **Gene name** Integrin subunit beta 3 **Gene symbol** ITGB3 **Previous gene symbols** - GP3A **Protein name** Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) ### Other names (2) - CD61 - GPIIIa ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Integrin beta subunits|Human platelet antigens **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 37 **Protein localisation evidence grade** Supported **Highest tissue expression** 59.1 **Tissue specificity (Gini)** 0.639 **Tissue specificity (tau)** 0.868 ## Pathways and interactions **KEGG gene identifiers** - hsa:3690 **Protein interaction confidence** 0.8642 **Protein interaction partners** 125 ### Reactome pathways (23) - R-HSA-114608 - R-HSA-1566948 - R-HSA-210990 - R-HSA-2129379 - R-HSA-216083 - R-HSA-2173789 - R-HSA-3000170 - R-HSA-3000178 - R-HSA-354192 - R-HSA-354194 - R-HSA-372708 - R-HSA-4420097 - R-HSA-445144 - R-HSA-5674135 - R-HSA-6802946 - R-HSA-6802948 - R-HSA-6802952 - R-HSA-6802955 - R-HSA-9649948 - R-HSA-9656223 - R-HSA-9769733 - R-HSA-9856532 - R-HSA-9860927 ## Genomic location **End position** 47313743 **Start position** 47253827 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000259207 **HGNC ID** HGNC:6156 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6156) **NCBI Gene ID** 3690 **UniProt ID** P05106 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Cell projection, lamellipodium membrane . Cell junction, focal adhesion . Postsynaptic cell membrane - Single-pass type I membrane protein . Synapse . - Plasma membrane ### Publication evidence (4) - PubMed 20020534 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20020534/) - PubMed 20702409 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20702409/) - PubMed 9195946 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9195946/) - PubMed 35687021 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35687021/) ## Tissue expression **Tissue specificity (tau)** 0.867925 **Expression inequality (Gini)** 0.639415 ### Highest expression Expression in transcripts per million **Artery - Aorta** 59.1 **Thyroid** 48.51 **Artery - Tibial** 43.22 **Artery - Coronary** 29.93 **Colon - Sigmoid** 27.58 ### All tissues (54) Expression in transcripts per million - Artery - Aorta59.1 - Thyroid48.51 - Artery - Tibial43.22 - Artery - Coronary29.93 - Colon - Sigmoid27.58 - Cells - Cultured fibroblasts23.12 - Uterus18.88 - Esophagus - Muscularis17.62 - Fallopian Tube16.58 - Esophagus - Gastroesophageal Junction14.46 - Adipose - Subcutaneous12.72 - Colon - Transverse11.51 - Bladder11.29 - Nerve - Tibial11.16 - Kidney - Cortex10.74 - Cells - EBV-transformed lymphocytes9.98 - Cervix - Endocervix8.62 - Lung8.41 - Cervix - Ectocervix8.04 - Breast - Mammary Tissue7.84 - Kidney - Medulla7.62 - Adipose - Visceral (Omentum)7 - Small Intestine - Terminal Ileum6.58 - Prostate5.35 - Vagina4.37 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (31) - GO:0001938 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001938) - GO:0007155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155) - GO:0007160 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007160) - GO:0007229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0010595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595) - GO:0010745 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010745) - GO:0010888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010888) - GO:0010989 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010989) - GO:0014909 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014909) - GO:0030168 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030168) - GO:0030949 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030949) - GO:0031589 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031589) - GO:0032369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032369) - GO:0033627 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033627) - GO:0033631 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033631) - GO:0034113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034113) - GO:0034446 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034446) - GO:0035295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035295) - GO:0038027 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038027) - GO:0042060 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042060) - GO:0043277 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043277) - GO:0045124 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045124) - GO:0046718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046718) - GO:0048333 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048333) And 6 more, listed on the interactive page. ### Cellular components (22) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005911 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005911) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0008305 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008305) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0031092 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031092) - GO:0031258 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031258) - GO:0031527 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031527) - GO:0031528 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031528) - GO:0032587 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032587) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0034683 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034683) - GO:0035866 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035866) - GO:0035867 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035867) - GO:0035868 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035868) - GO:0042470 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042470) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0070442 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070442) - GO:0071062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071062) - GO:0098978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098978) ### Molecular functions (17) - GO:0001968 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001968) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0003756 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003756) - GO:0004895 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004895) - GO:0005161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005161) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) - GO:0017134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017134) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0019960 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019960) - GO:0031994 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031994) - GO:0038132 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038132) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0043184 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043184) - GO:0050839 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050839) - GO:0050840 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050840) ## Related records ### Trials (186) - A Clinical Trial Designed to Evaluate the Safety and Efficacy Study of Luminate® in Inducing PVD (Posterior Vitreous Detachment) in Non-Proliferative Diabetic Retinopathy - A Clinical Trial Designed To Evaluate The Safety And Exploratory Efficacy Of 1.0 Mg Luminate® (Alg-1001) As A Treatment For Non-Exudative Macular Degeneration - A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke - A Phase 2 Open Label Study to Assess the PK/PD Properties of RUC-4 in Patients With a ST-elevation Myocardial Infarction - A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI - A Randomized Phase 1 Dose-Escalation Study of Subcutaneously(SC) Administered RUC-4 - A Randomized Trial of Early Discharge After Trans-radial Stenting of Coronary Arteries in Acute MI - A Randomized Trial of Early Discharge After Trans-radial Stenting of Coronary Arteries in Acute MI and Rescue-PCI - A Randomized Trial of Intracoronary Reopro to Improve Coronary Microvascular Function - A Safety And Efficacy Study Of Alg-1001 In Human Subjects With Symptomatic Focal Vitreomacular Adhesion - A Safety And Efficacy Study Of ALG-1001 In Human Subjects With Wet Age-Related Macular Degeneration - A Safety and Efficacy Study of Intetumumab, Alone and in Combination With Dacarbazine, in Participants With Stage 4 Melanoma - A Safety Study of Eptifibatide in Patients With Sickle Cell Disease - A Safety/Efficacy Study of Intracoronary Integrilin to Improve Balloon Angioplasty Outcomes for the Treatment of Heart Attacks - A Study Comparing the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Combination With Two Different Heparin Regimens in Patients Undergoing Percutaneous Coronary Intervention. - A Study Evaluating the Efficacy and Safety of Abciximab, an Anti-platelet Therapy, in Patients Undergoing High-risk Coronary Angioplasty - A Study Evaluating the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Patients With Unstable Angina Not Responding to Standard Medical Therapy Who Are Eligible for Coronary Angioplasty - [A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-tirofiban-in-c254d195-740e-4995-b772-aa41764b6a70.md) - A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse) - A Study of Effectiveness and Safety of Abciximab in Patients With Acute Ischemic Stroke (AbESTT-II) ### Drugs (13) - Abciximab Integrin alpha-IIb/beta-3 inhibitor - Abituzumab Integrin alpha-V/beta-3 inhibitor - ATN-161 Integrin alpha-V/beta-3 antagonist - Cilengitide Integrin alpha-V/beta-3 antagonist - Eptifibatide Integrin alpha-IIb/beta-3 inhibitor - Etaracizumab Integrin alpha-V/beta-3 antagonist - Intetumumab Integrin alpha-V/beta-3 antagonist - Risuteganib - Tadocizumab Integrin alpha-IIb/beta-3 antagonist - [Tirofiban](https://trialight.com/data/asset/tirofiban-922283ae-e04a-47c1-9941-cc6846a3635c.md) Integrin alpha-IIb/beta-3 inhibitor - Tirofiban hydrochloride Integrin alpha-IIb/beta-3 inhibitor - Zalunfiban Integrin alpha-IIb/beta-3 inhibitor - Zalunfiban acetate Integrin alpha-IIb/beta-3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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