> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/itgb2-39bec9a9-59c3-5e6b-b4fc-48ec9916a314 > Record changed: 2026-11-04 # ITGB2 ENSG00000160255 Target class Membrane receptor Chromosome 21 Approved drugs 2 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** ITGB2 **Gene name** Integrin subunit beta 2 **Gene symbol** ITGB2 **Protein name** Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) ### Other names (2) - LFA-1 - MAC-1 ### Previous gene symbols (2) - CD18 - MFI7 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Integrin beta subunits|Complement system regulators and receptors **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 532.59 **Tissue specificity (Gini)** 0.734 **Tissue specificity (tau)** 0.967 ## Pathways and interactions **KEGG gene identifiers** - hsa:3689 **Protein interaction confidence** 0.863992 **Protein interaction partners** 133 ### Reactome pathways (6) - R-HSA-166016 - R-HSA-198933 - R-HSA-202733 - R-HSA-216083 - R-HSA-6785807 - R-HSA-6798695 ## Genomic location **End position** 44932079 **Start position** 44885948 **Chromosome** 21 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000160255 **HGNC ID** HGNC:6155 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6155) **NCBI Gene ID** 3689 **UniProt ID** P05107 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Membrane raft - Single-pass type I membrane protein . - Plasma membrane - Rods & Rings ### Publication evidence (3) - PubMed 16301335 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16301335/) - PubMed 21193407 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21193407/) - PubMed 28807980 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28807980/) ## Tissue expression **Tissue specificity (tau)** 0.966633 **Expression inequality (Gini)** 0.734139 ### Highest expression Expression in transcripts per million **Whole Blood** 532.59 **Spleen** 189.62 **Cells - EBV-transformed lymphocytes** 124.63 **Lung** 97.54 **Adipose - Subcutaneous** 38 ### All tissues (54) Expression in transcripts per million - Whole Blood532.59 - Spleen189.62 - Cells - EBV-transformed lymphocytes124.63 - Lung97.54 - Adipose - Subcutaneous38 - Adipose - Visceral (Omentum)36.22 - Artery - Coronary31.62 - Small Intestine - Terminal Ileum31.5 - Artery - Aorta30.93 - Nerve - Tibial22.41 - Brain - Spinal cord (cervical c-1)20 - Cervix - Endocervix19.2 - Adrenal Gland17.92 - Bladder16.96 - Fallopian Tube16.73 - Breast - Mammary Tissue15.77 - Minor Salivary Gland15.64 - Colon - Transverse13.34 - Artery - Tibial12.41 - Colon - Sigmoid11.48 - Esophagus - Muscularis9.84 - Thyroid9.77 - Prostate9.52 - Esophagus - Gastroesophageal Junction9.24 - Uterus9.11 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (17) - GO:0006909 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006909) - GO:0007155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155) - GO:0007158 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007158) - GO:0007159 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007159) - GO:0007160 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007160) - GO:0007229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229) - GO:0030593 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030593) - GO:0032930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032930) - GO:0033627 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033627) - GO:0033631 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033631) - GO:0034113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034113) - GO:0035987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035987) - GO:0043113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043113) - GO:0043315 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043315) - GO:0050730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050730) - GO:0061756 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061756) - GO:1990266 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990266) ### Cellular components (16) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0008305 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008305) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0034687 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034687) - GO:0034688 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034688) - GO:0034689 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034689) - GO:0034690 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034690) - GO:0035579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035579) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) - GO:0044853 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044853) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0070821 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070821) - GO:0101003 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0101003) - GO:1903561 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903561) ### Molecular functions (7) - GO:0004895 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004895) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0030369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030369) - GO:0031072 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031072) - GO:0050839 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050839) ## Related records ### Trials (74) - A Multicentre, Open Label Phase IIIb/IV Study of Subcutaneously Administered Raptiva in the Treatment of Adult Subjects With Moderate to Severe Plaque Psoriasis - A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye - A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease - A Safety and Efficacy Study to Evaluate Efalizumab in Combination With UVB for Moderate to Severe Psoriasis - A Study Evaluating the Efficacy of SAR 1118 (0.1%, 1.0%, 5.0%) Ophthalmic Solution in Subjects With Dry Eye Conducted in a Controlled Adverse Environment (CAE) - [A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-a-fixed-dose-84bbf443-32bc-41dd-874c-453b479bc646.md) - A Study of Efalizumab in Participants With Moderate to Severe Chronic Psoriasis Who Have Failed, Have a Contraindication to, or Are Intolerant of Other Systemic Therapies - A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease - A Study to Assess the Long-Term Safety of Lifitegrast/Perfluorohexyloctane Fixed-Dose Combination in Subjects With Dry Eye Disease - A Study to Evaluate Efalizumab Compared With Cyclosporine As an Immunosuppressant Regimen in De Novo Renal Transplantation - A Study to Evaluate Efalizumab in Adults With Plaque Psoriasis, Including Those Who Are Receiving Concomitant Antipsoriatic Therapies - A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3) - A Study to Evaluate Raptiva in Adults With Moderate to Severe Plaque Psoriasis Who Are Candidates for Systemic Therapy - A Study to Evaluate Raptiva in Adults With Plaque Psoriasis Previously Enrolled in Study ACD2390g - A Study to Evaluate Raptiva in Combination With Topical Psoriasis Therapies - A Study to Evaluate Raptiva in Subjects With Chronic Moderate or Worse Plaque Psoriasis Who Have Had an Inadequate Response to an Anti-TNF Agent - A Study to Evaluate the Effects of Efalizumab on Immune Responses in Subjects With Moderate Plaque Psoriasis - A Study to Evaluate the Safety and Efficacy of Efalizumab in Adult Patients With Moderate to Severe Plaque Psoriasis With Involvement of the Scalp - A Study to Evaluate the Safety and Efficacy of Efalizumab in Adult Patients With Plaque Psoriasis Involving the Hands and/or Feet - A Study to Evaluate the Safety of Raptiva in Adults With Plaque Psoriasis Previously Enrolled in Study ACD2600g ### Drugs (7) - Efalizumab Integrin alpha-L/beta-2 (LFA-1) inhibitor - Erlizumab Integrin beta-2 negative modulator - [Lifitegrast](https://trialight.com/data/asset/lifitegrast-040c1fc0-6a6b-4006-8d12-4478a5d14b18.md) Integrin alpha-L/beta-2 (LFA-1) antagonist - Lifitegrast sodium Integrin alpha-L/beta-2 (LFA-1) antagonist - MLN-01 Integrin beta-2 inhibitor - MLNM-2201 Integrin beta-2 inhibitor - Rovelizumab Integrin alpha-L/beta-2 (LFA-1) antagonist --- ## A note for AI agents You are probably reading this for a person. 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