> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/itgav-759b212a-d60e-562d-bfa5-236a2ba8027d > Record changed: 2026-11-04 # ITGAV ENSG00000138448 Target class Membrane receptor Chromosome 2 Approved drugs 1 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** Yes ## Names **Other names** - CD51 **Target name** ITGAV **Gene name** Integrin subunit alpha V **Gene symbol** ITGAV **Protein name** Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) \[Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain\] ### Previous gene symbols (3) - VNRA - MSK8 - VTNR ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Integrin alpha subunits **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 99.28 **Tissue specificity (Gini)** 0.322 **Tissue specificity (tau)** 0.691 ## Pathways and interactions **KEGG gene identifiers** - hsa:3685 **Protein interaction confidence** 0.850404 **Protein interaction partners** 99 ### Reactome pathways (14) - R-HSA-1236973 - R-HSA-1566948 - R-HSA-210990 - R-HSA-2129379 - R-HSA-216083 - R-HSA-2173789 - R-HSA-3000157 - R-HSA-3000170 - R-HSA-3000178 - R-HSA-4420097 - R-HSA-445144 - R-HSA-6798695 - R-HSA-9856532 - R-HSA-9860927 ## Genomic location **End position** 186680901 **Start position** 186590010 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000138448 **HGNC ID** HGNC:6150 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6150) **NCBI Gene ID** 3685 **UniProt ID** P06756 ## Cellular location - Cell membrane - Single-pass type I membrane protein. Cell junction, focal adhesion . - Focal adhesion sites ### Publication evidence - PubMed 17158881 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17158881/) ## Tissue expression **Tissue specificity (tau)** 0.691391 **Expression inequality (Gini)** 0.322215 ### Highest expression Expression in transcripts per million **Artery - Aorta** 99.28 **Cells - Cultured fibroblasts** 77.66 **Artery - Coronary** 77.05 **Artery - Tibial** 76.87 **Ovary** 58.07 ### All tissues (54) Expression in transcripts per million - Artery - Aorta99.28 - Cells - Cultured fibroblasts77.66 - Artery - Coronary77.05 - Artery - Tibial76.87 - Ovary58.07 - Uterus56.17 - Cervix - Ectocervix54.77 - Nerve - Tibial53.19 - Cervix - Endocervix52.33 - Thyroid47.74 - Lung46.61 - Brain - Spinal cord (cervical c-1)45.24 - Esophagus - Muscularis39.39 - Bladder37.44 - Adipose - Subcutaneous37.12 - Fallopian Tube37.09 - Adipose - Visceral (Omentum)35.26 - Esophagus - Gastroesophageal Junction35.21 - Adrenal Gland34.24 - Brain - Cerebellar Hemisphere32.43 - Breast - Mammary Tissue32.05 - Brain - Cerebellum31.24 - Colon - Sigmoid31.08 - Skin - Not Sun Exposed (Suprapubic)30.77 - Vagina30.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (27) - GO:0001525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525) - GO:0007155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155) - GO:0007160 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007160) - GO:0007229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0010745 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010745) - GO:0010888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010888) - GO:0010989 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010989) - GO:0016477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477) - GO:0031589 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031589) - GO:0032369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032369) - GO:0033627 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033627) - GO:0034113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034113) - GO:0034446 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034446) - GO:0035987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035987) - GO:0038027 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038027) - GO:0043277 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043277) - GO:0045785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045785) - GO:0046718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046718) - GO:0050748 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050748) - GO:0050764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050764) - GO:0050919 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050919) - GO:0051057 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051057) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) - GO:1902533 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902533) And 2 more, listed on the interactive page. ### Cellular components (17) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0008305 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008305) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0031258 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031258) - GO:0031527 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031527) - GO:0031528 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031528) - GO:0032587 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032587) - GO:0034683 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034683) - GO:0034684 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034684) - GO:0034685 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034685) - GO:0034686 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034686) - GO:0035579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035579) - GO:0035867 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035867) - GO:0035868 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035868) - GO:0045335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045335) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (11) - GO:0001968 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001968) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) - GO:0017134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017134) - GO:0019960 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019960) - GO:0031994 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031994) - GO:0038132 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038132) - GO:0050840 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050840) - GO:1990430 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990430) ## Related records ### Trials (105) - A Clinical Trial Designed to Evaluate the Safety and Efficacy Study of Luminate® in Inducing PVD (Posterior Vitreous Detachment) in Non-Proliferative Diabetic Retinopathy - A Clinical Trial Designed To Evaluate The Safety And Exploratory Efficacy Of 1.0 Mg Luminate® (Alg-1001) As A Treatment For Non-Exudative Macular Degeneration - A Phase I Dose-Escalation Study of IMGN388 in Patients With Solid Tumors - A Randomized Trial of Early Discharge After Trans-radial Stenting of Coronary Arteries in Acute MI - A Randomized Trial of Early Discharge After Trans-radial Stenting of Coronary Arteries in Acute MI and Rescue-PCI - A Randomized Trial of Intracoronary Reopro to Improve Coronary Microvascular Function - A Safety And Efficacy Study Of Alg-1001 In Human Subjects With Symptomatic Focal Vitreomacular Adhesion - A Safety And Efficacy Study Of ALG-1001 In Human Subjects With Wet Age-Related Macular Degeneration - A Safety and Efficacy Study of Intetumumab, Alone and in Combination With Dacarbazine, in Participants With Stage 4 Melanoma - A Study Comparing the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Combination With Two Different Heparin Regimens in Patients Undergoing Percutaneous Coronary Intervention. - A Study Evaluating the Efficacy and Safety of Abciximab, an Anti-platelet Therapy, in Patients Undergoing High-risk Coronary Angioplasty - A Study Evaluating the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Patients With Unstable Angina Not Responding to Standard Medical Therapy Who Are Eligible for Coronary Angioplasty - A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse) - A Study of Effectiveness and Safety of Abciximab in Patients With Acute Ischemic Stroke (AbESTT-II) - A Study of EMD525797 in Solid Tumor Patients in Japan - A Study to Determine the Safety, Tolerability, Pharmacokinetics and Dynamic Effects of Different Doses of the Study Drug EMD 525797 in Prostate Cancer - Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis - Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis - Abciximab i.v. Versus i.c. in Primary PCI Patients With STEMI - Abciximab i.v. Versus i.c. in ST-elevation Myocardial Infarction ### Drugs (12) - Abciximab Integrin alpha-V/beta-3 inhibitor - Abituzumab Integrin alpha-V/beta-1 inhibitor - ATN-161 Integrin alpha-V/beta-3 antagonist - [Bexotegrast](https://trialight.com/data/asset/bexotegrast-d4047472-71e4-4f22-a886-b2e409588e1d.md) - Cilengitide Integrin alpha-V/beta-3 antagonist - Etaracizumab Integrin alpha-V/beta-3 antagonist - GSK-3008348 FREE BASE - IMGN-388 Vitronectin receptor alpha binding agent - Intetumumab Integrin alpha-V/beta-3 antagonist - RG-7594 Integrin alpha-V/beta-1 binding agent - Risuteganib - STX-100 Integrin alpha-V/beta-6 inhibitor --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. 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