> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/itgal-064a7e92-6142-55d1-b463-03e74b424f25 > Record changed: 2026-11-04 # ITGAL ENSG00000005844 Target class Adhesion Chromosome 16 Approved drugs 2 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Target name** ITGAL **Gene name** Integrin subunit alpha L **Gene symbol** ITGAL **Previous gene symbols** - CD11A **Protein name** Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) ### Other names (3) - HNA-5 - LFA-1 - LFA1A ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Integrin alpha subunits|MicroRNA protein coding host genes|Human neutrophil antigens **Target class** Adhesion **Target type** Human gene ## Expression and localisation **Tissues expressed in** 38 **Highest tissue expression** 111.53 **Tissue specificity (Gini)** 0.781 **Tissue specificity (tau)** 0.94 ## Pathways and interactions **KEGG gene identifiers** - hsa:3683 **Protein interaction confidence** 0.874388 **Protein interaction partners** 67 ### Reactome pathways (5) - R-HSA-198933 - R-HSA-202733 - R-HSA-216083 - R-HSA-6798695 - R-HSA-8949275 ## Genomic location **End position** 30523567 **Start position** 30472658 **Chromosome** 16 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000005844 **HGNC ID** HGNC:6148 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6148) **NCBI Gene ID** 3683 **UniProt ID** P20701 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Membrane raft . Note=Upon antigen recognition by the TCR, is recruited to lipid rafts (PubMed:15684041). . ### Publication evidence (2) - PubMed 15684041 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15684041/) - PubMed 16301335 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16301335/) ## Tissue expression **Tissue specificity (tau)** 0.939773 **Expression inequality (Gini)** 0.780981 ### Highest expression Expression in transcripts per million **Spleen** 111.53 **Whole Blood** 110.59 **Cells - EBV-transformed lymphocytes** 74.61 **Lung** 36.26 **Small Intestine - Terminal Ileum** 22.25 ### All tissues (54) Expression in transcripts per million - Spleen111.53 - Whole Blood110.59 - Cells - EBV-transformed lymphocytes74.61 - Lung36.26 - Small Intestine - Terminal Ileum22.25 - Liver7.49 - Fallopian Tube6.93 - Adipose - Visceral (Omentum)5.6 - Bladder5.06 - Colon - Transverse5.01 - Cervix - Endocervix4.69 - Thyroid4.69 - Adipose - Subcutaneous4.05 - Minor Salivary Gland4.02 - Vagina3.91 - Prostate3.86 - Brain - Spinal cord (cervical c-1)3.74 - Breast - Mammary Tissue3.63 - Artery - Coronary3.47 - Stomach3.25 - Nerve - Tibial3.12 - Cervix - Ectocervix3.08 - Artery - Aorta2.76 - Uterus2.66 - Esophagus - Mucosa2.49 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0002291 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002291) - GO:0007157 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007157) - GO:0007158 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007158) - GO:0007159 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007159) - GO:0007160 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007160) - GO:0033627 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033627) - GO:0033631 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033631) - GO:0035683 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035683) - GO:0043113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043113) ### Cellular components (8) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0008305 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008305) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0034687 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034687) - GO:0035579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035579) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (4) - GO:0004895 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004895) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030369) - GO:0050839 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050839) ## Related records ### Trials (74) - A Multicentre, Open Label Phase IIIb/IV Study of Subcutaneously Administered Raptiva in the Treatment of Adult Subjects With Moderate to Severe Plaque Psoriasis - A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye - A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease - A Safety and Efficacy Study to Evaluate Efalizumab in Combination With UVB for Moderate to Severe Psoriasis - A Study Evaluating the Efficacy of SAR 1118 (0.1%, 1.0%, 5.0%) Ophthalmic Solution in Subjects With Dry Eye Conducted in a Controlled Adverse Environment (CAE) - [A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-a-fixed-dose-84bbf443-32bc-41dd-874c-453b479bc646.md) - A Study of Efalizumab in Participants With Moderate to Severe Chronic Psoriasis Who Have Failed, Have a Contraindication to, or Are Intolerant of Other Systemic Therapies - A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease - A Study to Assess the Long-Term Safety of Lifitegrast/Perfluorohexyloctane Fixed-Dose Combination in Subjects With Dry Eye Disease - A Study to Evaluate Efalizumab Compared With Cyclosporine As an Immunosuppressant Regimen in De Novo Renal Transplantation - A Study to Evaluate Efalizumab in Adults With Plaque Psoriasis, Including Those Who Are Receiving Concomitant Antipsoriatic Therapies - A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3) - A Study to Evaluate Raptiva in Adults With Moderate to Severe Plaque Psoriasis Who Are Candidates for Systemic Therapy - A Study to Evaluate Raptiva in Adults With Plaque Psoriasis Previously Enrolled in Study ACD2390g - A Study to Evaluate Raptiva in Combination With Topical Psoriasis Therapies - A Study to Evaluate Raptiva in Subjects With Chronic Moderate or Worse Plaque Psoriasis Who Have Had an Inadequate Response to an Anti-TNF Agent - A Study to Evaluate the Effects of Efalizumab on Immune Responses in Subjects With Moderate Plaque Psoriasis - A Study to Evaluate the Safety and Efficacy of Efalizumab in Adult Patients With Moderate to Severe Plaque Psoriasis With Involvement of the Scalp - A Study to Evaluate the Safety and Efficacy of Efalizumab in Adult Patients With Plaque Psoriasis Involving the Hands and/or Feet - A Study to Evaluate the Safety of Raptiva in Adults With Plaque Psoriasis Previously Enrolled in Study ACD2600g ### Drugs (5) - Efalizumab Integrin alpha-L/beta-2 (LFA-1) inhibitor - [Lifitegrast](https://trialight.com/data/asset/lifitegrast-040c1fc0-6a6b-4006-8d12-4478a5d14b18.md) Integrin alpha-L/beta-2 (LFA-1) antagonist - Lifitegrast sodium Integrin alpha-L/beta-2 (LFA-1) antagonist - Odulimomab Leukocyte adhesion glycoprotein LFA-1 alpha inhibitor - Rovelizumab Integrin alpha-L/beta-2 (LFA-1) antagonist --- ## A note for AI agents You are probably reading this for a person. 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