> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/itga4-bb7d0d23-7ab8-5354-b421-1d71630aa5ed > Record changed: 2026-10-13 # ITGA4 ENSG00000115232 Target class Membrane receptor Chromosome 2 Approved drugs 2 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Other names** - CD49d **Target name** ITGA4 **Gene name** Integrin subunit alpha 4 **Gene symbol** ITGA4 **Previous gene symbols** - CD49D **Protein name** Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Integrin alpha subunits **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 30 **Protein localisation evidence grade** Approved **Highest tissue expression** 83.08 **Tissue specificity (Gini)** 0.752 **Tissue specificity (tau)** 0.966 ## Pathways and interactions **KEGG gene identifiers** - hsa:3676 **Protein interaction confidence** 0.82788 **Protein interaction partners** 92 ### Reactome pathways (5) - R-HSA-198933 - R-HSA-202733 - R-HSA-216083 - R-HSA-8949275 - R-HSA-9679191 ## Genomic location **End position** 181538940 **Start position** 181457202 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000115232 **HGNC ID** HGNC:6140 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6140) **NCBI Gene ID** 3676 **UniProt ID** P13612 ## Cellular location - Membrane - Single-pass type I membrane protein . - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.965507 **Expression inequality (Gini)** 0.752175 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 83.08 **Cells - Cultured fibroblasts** 35 **Spleen** 22.61 **Lung** 10.29 **Small Intestine - Terminal Ileum** 8.08 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes83.08 - Cells - Cultured fibroblasts35 - Spleen22.61 - Lung10.29 - Small Intestine - Terminal Ileum8.08 - Cervix - Endocervix6.71 - Whole Blood6.25 - Cervix - Ectocervix5.55 - Colon - Transverse3.16 - Nerve - Tibial3.06 - Brain - Cerebellum2.89 - Brain - Cerebellar Hemisphere2.73 - Adipose - Subcutaneous2.68 - Adipose - Visceral (Omentum)2.52 - Artery - Coronary2.4 - Vagina2.21 - Fallopian Tube2.19 - Colon - Sigmoid2.19 - Minor Salivary Gland2.15 - Breast - Mammary Tissue2.15 - Artery - Aorta2.1 - Thyroid1.85 - Bladder1.79 - Kidney - Medulla1.77 - Uterus1.58 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (14) - GO:0003366 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003366) - GO:0007159 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007159) - GO:0007160 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007160) - GO:0030183 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030183) - GO:0033631 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033631) - GO:0034113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034113) - GO:0034446 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034446) - GO:0035987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035987) - GO:0043113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043113) - GO:0045906 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045906) - GO:0050901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050901) - GO:1904646 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904646) - GO:1905564 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905564) - GO:2000353 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000353) ### Cellular components (7) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0034668 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034668) - GO:0034669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034669) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (5) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) - GO:0019960 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019960) - GO:0050839 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050839) ## Related records ### Trials (226) - A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in Participants With Secondary Progressive Multiple Sclerosis - A Clinical Trial of Natalizumab in Individuals With Moderately to Severely Active Crohn's Disease - A Dose-Finding Study of Vedolizumab for Treatment of Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease (GvHD) in Participants Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) - A HIV Vaccine Trial in Individuals Who Started Antiretrovirals During Primary or Chronic Infection (EHVA T02) - A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD) - A Multicenter Study to Assess the Effect of Plasma Exchange in Accelerating the Clearance of Natalizumab in Subjects With Multiple Sclerosis (MS) - A Multicentered Prospective Cohort Study of Chinese IBD Patients - A Pharmacokinetic (PK) Study of Natalizumab (Tysabri) at Steady State - A Phase II, Multicenter, Open-Label, Long-Term Study of the Safety, Tolerability, and Efficacy of Intravenous Natalizumab in Subjects With Rheumatoid Arthritis Who Have Previously Participated in Study ELN100226-RA201 - A Pilot Study to Characterize the Biological Effect of a Pre-planned 12 Week Dose Interruption of Natalizumab - A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Autoinjector (PFS+AI) in Healthy Participants - A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Needle Safety Device (PFS+NSD) in Healthy Participants - A Proof of Concept Study to Evaluate the Effectiveness of Tysabri in Relapsing Remitting Multiple Sclerosis (RRMS) Patient Bladder Function - A Proof-of-Concept Study to Correlate Retinal Nerve Fiber Layer Changes in Patients With Multiple Sclerosis Treated With Natalizumab or Interferon Beta 1-a - A Prospective, Open-label, Non-randomized, Clinical Trial to Determine if Natalizumab (Tysabri®) Improves Ambulatory Measures in Relapsing-remitting Multiple Sclerosis (RRMS) Patients - A Study for Tysabri Participant Preference - A Study of End of Dose Phenomena in Subcutaneous Natalizumab Treated Multiple Sclerosis (MS) Participants - A Study of Intravenous Vedolizumab Administered Every 4 Weeks in Japanese Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease - A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease - A Study of Mirikizumab (LY3074828) in Participants With Ulcerative Colitis ### Drugs (5) - Abrilumab Integrin alpha-4/beta-7 inhibitor - Firategrast Integrin alpha-4/beta-1 antagonist - Natalizumab Integrin alpha-4/beta-7 inhibitor - UCB-1184197 Integrin alpha-4 inhibitor - [Vedolizumab](https://trialight.com/data/asset/vedolizumab-4085e162-ab16-49f7-aa46-d779d6e24562.md) Integrin alpha-4/beta-7 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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