> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/irs1-adc07240-de71-5558-971b-bf2953e2abca > Record changed: 2026-11-04 # IRS1 ENSG00000169047 Target class Unclassified protein Chromosome 2 ## Druggability **Chemical probe available** No ## Names **Other names** - HIRS-1 **Target name** IRS1 **Gene name** Insulin receptor substrate 1 **Gene symbol** IRS1 **Protein name** Insulin receptor substrate 1 (IRS-1) ## Classification **Gene biotype** Protein coding **Gene family** Pleckstrin homology domain containing **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Approved **Highest tissue expression** 50.34 **Tissue specificity (Gini)** 0.542 **Tissue specificity (tau)** 0.803 ## Pathways and interactions **KEGG gene identifiers** - hsa:3667 **Protein interaction confidence** 0.866081 **Protein interaction partners** 123 ### Reactome pathways (18) - R-HSA-109704 - R-HSA-112399 - R-HSA-112412 - R-HSA-1257604 - R-HSA-1266695 - R-HSA-198203 - R-HSA-201556 - R-HSA-2219530 - R-HSA-2428928 - R-HSA-2586552 - R-HSA-5673001 - R-HSA-6811558 - R-HSA-74713 - R-HSA-74749 - R-HSA-9603381 - R-HSA-9725370 - R-HSA-982772 - R-HSA-9842663 ## Genomic location **End position** 226799820 **Start position** 226731312 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000169047 **HGNC ID** HGNC:6125 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6125) **NCBI Gene ID** 3667 **UniProt ID** P35568 ## Cellular location - Cytoplasm . Nucleus . Note=Nuclear or cytoplasmic localization of IRS1 correlates with the transition from proliferation to chondrogenic differentiation. . - Cytosol - Nucleoplasm - Plasma membrane - Vesicles ### Publication evidence - PubMed 19639489 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19639489/) ## Tissue expression **Tissue specificity (tau)** 0.803412 **Expression inequality (Gini)** 0.542164 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 50.34 **Cervix - Endocervix** 43.16 **Ovary** 42.29 **Fallopian Tube** 41.62 **Thyroid** 37.36 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts50.34 - Cervix - Endocervix43.16 - Ovary42.29 - Fallopian Tube41.62 - Thyroid37.36 - Uterus31.33 - Bladder23.89 - Colon - Sigmoid19.3 - Cervix - Ectocervix18.77 - Prostate15.35 - Breast - Mammary Tissue14.66 - Vagina14 - Esophagus - Muscularis12.91 - Artery - Tibial11.35 - Adrenal Gland10.67 - Adipose - Subcutaneous10.62 - Lung10.59 - Nerve - Tibial9.98 - Esophagus - Gastroesophageal Junction9.92 - Artery - Aorta9.76 - Skin - Not Sun Exposed (Suprapubic)9.06 - Skin - Sun Exposed (Lower leg)8.7 - Adipose - Visceral (Omentum)8.65 - Colon - Transverse8.38 - Brain - Cerebellar Hemisphere8.35 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (14) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008286 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008286) - GO:0010907 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010907) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0032000 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032000) - GO:0032868 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032868) - GO:0032869 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032869) - GO:0042593 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042593) - GO:0043491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043491) - GO:0045725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045725) - GO:0046326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046326) - GO:0046628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046628) - GO:0046676 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046676) - GO:0048009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048009) ### Cellular components (5) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901) ### Molecular functions (8) - GO:0001784 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001784) - GO:0005068 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005068) - GO:0005158 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005158) - GO:0005159 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005159) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030159 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030159) - GO:0035591 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035591) - GO:0043548 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043548) ## Related records ### Trials (3) - [A Phase 1 Clinical Study Comparing GS101 and Dupixent® After Subcutaneous Injection](https://trialight.com/data/trial/a-phase-1-clinical-study-comparing-gs101-and-dupixent-after-901f1eef-475a-47bb-94f7-9da51ce0e895.md) - A Phase III Study of GS101 Injection to Dupixent® - Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG ### Drugs (1) - [Aganirsen](https://trialight.com/data/asset/aganirsen-b7c3d975-6d77-48ef-b4a4-71e2e3d5e09e.md) Insulin receptor substrate 1 mRNA antisense inhibitor --- ## A note for AI agents You are probably reading this for a person. 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