> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/inhba-1f763b06-8782-5c80-88da-569a281eb471 > Record changed: 2026-10-13 # INHBA ENSG00000122641 Target class Secreted protein Chromosome 7 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** INHBA **Gene name** Inhibin subunit beta A **Gene symbol** INHBA **Protein name** Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF) ## Classification **Gene biotype** Protein coding **Gene family** Inhibin subunits **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 25 **Highest tissue expression** 21.22 **Tissue specificity (Gini)** 0.703 **Tissue specificity (tau)** 0.887 ## Pathways and interactions **KEGG gene identifiers** - hsa:3624 **Protein interaction confidence** 0.9234 **Protein interaction partners** 15 ### Reactome pathways (5) - R-HSA-1502540 - R-HSA-201451 - R-HSA-209822 - R-HSA-2473224 - R-HSA-9839406 ## Genomic location **End position** 41705834 **Start position** 41667168 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000122641 **HGNC ID** HGNC:6066 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6066) **NCBI Gene ID** 3624 **UniProt ID** P08476 ## Cellular location - Secreted . ### Publication evidence - PubMed 11279126 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11279126/) ## Tissue expression **Tissue specificity (tau)** 0.887397 **Expression inequality (Gini)** 0.702544 ### Highest expression Expression in transcripts per million **Artery - Tibial** 21.22 **Artery - Aorta** 19.33 **Artery - Coronary** 17.73 **Cells - Cultured fibroblasts** 17.06 **Lung** 8.32 ### All tissues (54) Expression in transcripts per million - Artery - Tibial21.22 - Artery - Aorta19.33 - Artery - Coronary17.73 - Cells - Cultured fibroblasts17.06 - Lung8.32 - Esophagus - Muscularis7.79 - Esophagus - Gastroesophageal Junction7.2 - Nerve - Tibial4.63 - Uterus4.44 - Ovary3.34 - Minor Salivary Gland3.29 - Skin - Sun Exposed (Lower leg)2.34 - Liver2.18 - Kidney - Medulla2.17 - Heart - Atrial Appendage1.87 - Cervix - Endocervix1.81 - Skin - Not Sun Exposed (Suprapubic)1.81 - Prostate1.55 - Fallopian Tube1.35 - Vagina1.26 - Thyroid1.25 - Cervix - Ectocervix1.12 - Testis1.11 - Breast - Mammary Tissue1.02 - Adipose - Subcutaneous1.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (36) - GO:0001541 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001541) - GO:0001942 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001942) - GO:0002244 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002244) - GO:0006357 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006357) - GO:0006952 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006952) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0008584 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008584) - GO:0009611 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009611) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0021773 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0021773) - GO:0030154 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030154) - GO:0030308 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030308) - GO:0032689 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032689) - GO:0032924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032924) - GO:0032926 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032926) - GO:0035987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035987) - GO:0042326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042326) - GO:0042476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042476) - GO:0042541 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042541) - GO:0042701 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042701) - GO:0045578 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045578) - GO:0045648 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045648) - GO:0045650 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045650) And 11 more, listed on the interactive page. ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043509) - GO:0043512 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043512) ### Molecular functions (8) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005179 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005179) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083) - GO:0017046 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017046) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0070699 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070699) - GO:0140311 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140311) ## Related records ### Trials (46) - A Clinical Study of MK-7962 in Healthy Chinese Participants (MK-7962-021) - A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION) - A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038) - A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024) - A Phase 2 Study of Intravenous or Subcutaneous Dosing of Sotatercept (ACE-011) in Patients With End-Stage Kidney Disease on Hemodialysis - A Phase 2a Study To Evaluate The Pharmacokinetics, Safety, Efficacy, Tolerability, And Pharmacodynamics of Sotatercept (ACE-011) for the Correction of Anemia in Subjects With End-stage Renal Disease on Hemodialysis. - A Phase IIa Study of Sotatercept on Bone Mass and Turnover in Patients With Multiple Myeloma - A Safety, Tolerability and Efficacy Study of ACE-011 in Patients With Osteolytic Lesions of Multiple Myeloma - [A Study of Sotatercept (MK-7962) in Healthy Females Administered as a Liquid Formulation in an Autoinjector Versus the Lyophilized Formulation (MK-7962-027)](https://trialight.com/data/trial/a-study-of-sotatercept-mk-7962-in-healthy-females-731ffa41-4d48-4621-bdc5-7e9e1d6eeb42.md) - A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-032) - A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in India (MK-7962-037) - A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy - A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16) - A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension - A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR) - A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH) - A Study of Sotatercept in Japanese Pulmonary Arterial Hypertension (PAH) Participants (MK-7962-020) - A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH) - A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP) - A Study to Examine the Safety and Tolerability of Single Ascending Doses of REGN2477 ### Drugs (2) - [Garetosmab](https://trialight.com/data/asset/garetosmab-44b08868-ecb5-4887-aa32-030e5ec78483.md) Inhibin beta A chain inhibitor - [Sotatercept](https://trialight.com/data/asset/sotatercept-1d23bb90-6d38-4e89-8d84-f694491a5993.md) Inhibin beta A chain inhibitor --- ## A note for AI agents You are probably reading this for a person. 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