INHBA
ENSG00000122641
Target class
Secreted protein
Chromosome
7
Approved drugs
1
Clinical candidates (approved and in development)
2
- Approved drugs
- 1
- Clinical candidates (approved and in development)
- 2
- Chemical probe available
- No
- Target name
- INHBA
- Gene name
- Inhibin subunit beta A
- Gene symbol
- INHBA
- Protein name
- Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)
- Gene biotype
- Protein coding
- Gene family
- Inhibin subunits
- Target class
- Secreted protein
- Target type
- Human gene
- Tissues expressed in
- 25
- Highest tissue expression
- 21.22
- Tissue specificity (Gini)
- 0.703
- Tissue specificity (tau)
- 0.887
- KEGG gene identifiers
- hsa:3624
- Protein interaction confidence
- 0.9234
- Protein interaction partners
- 15
- R-HSA-1502540
- R-HSA-201451
- R-HSA-209822
- R-HSA-2473224
- R-HSA-9839406
- End position
- 41705834
- Start position
- 41667168
- Chromosome
- 7
- Strand
- Reverse
- Secreted .
Publication evidence
- PubMed 11279126
- Tissue specificity (tau)
- 0.887397
- Expression inequality (Gini)
- 0.702544
Expression in transcripts per million
- Artery - Tibial
- 21.22
- Artery - Aorta
- 19.33
- Artery - Coronary
- 17.73
- Cells - Cultured fibroblasts
- 17.06
- Lung
- 8.32
Expression in transcripts per million
- Artery - Tibial21.22
- Artery - Aorta19.33
- Artery - Coronary17.73
- Cells - Cultured fibroblasts17.06
- Lung8.32
- Esophagus - Muscularis7.79
- Esophagus - Gastroesophageal Junction7.2
- Nerve - Tibial4.63
- Uterus4.44
- Ovary3.34
- Minor Salivary Gland3.29
- Skin - Sun Exposed (Lower leg)2.34
- Liver2.18
- Kidney - Medulla2.17
- Heart - Atrial Appendage1.87
- Cervix - Endocervix1.81
- Skin - Not Sun Exposed (Suprapubic)1.81
- Prostate1.55
- Fallopian Tube1.35
- Vagina1.26
- Thyroid1.25
- Cervix - Ectocervix1.12
- Testis1.11
- Breast - Mammary Tissue1.02
- Adipose - Subcutaneous1.01
And 29 more, listed on the interactive page.
- GO:0001541
- GO:0001942
- GO:0002244
- GO:0006357
- GO:0006952
- GO:0007166
- GO:0007267
- GO:0008285
- GO:0008584
- GO:0009611
- GO:0010628
- GO:0021773
- GO:0030154
- GO:0030308
- GO:0032689
- GO:0032924
- GO:0032926
- GO:0035987
- GO:0042326
- GO:0042476
- GO:0042541
- GO:0042701
- GO:0045578
- GO:0045648
- GO:0045650
And 11 more, listed on the interactive page.
- GO:0005576
- GO:0005886
- GO:0043509
- GO:0043512
- GO:0005125
- GO:0005179
- GO:0005515
- GO:0008083
- GO:0017046
- GO:0042802
- GO:0070699
- GO:0140311
Related records
Trials (46)
- A Clinical Study of MK-7962 in Healthy Chinese Participants (MK-7962-021)
- A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)
- A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
- A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)
- A Phase 2 Study of Intravenous or Subcutaneous Dosing of Sotatercept (ACE-011) in Patients With End-Stage Kidney Disease on Hemodialysis
- A Phase 2a Study To Evaluate The Pharmacokinetics, Safety, Efficacy, Tolerability, And Pharmacodynamics of Sotatercept (ACE-011) for the Correction of Anemia in Subjects With End-stage Renal Disease on Hemodialysis.
- A Phase IIa Study of Sotatercept on Bone Mass and Turnover in Patients With Multiple Myeloma
- A Safety, Tolerability and Efficacy Study of ACE-011 in Patients With Osteolytic Lesions of Multiple Myeloma
- A Study of Sotatercept (MK-7962) in Healthy Females Administered as a Liquid Formulation in an Autoinjector Versus the Lyophilized Formulation (MK-7962-027)
- A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-032)
- A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in India (MK-7962-037)
- A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy
- A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16)
- A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension
- A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR)
- A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH)
- A Study of Sotatercept in Japanese Pulmonary Arterial Hypertension (PAH) Participants (MK-7962-020)
- A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH)
- A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP)
- A Study to Examine the Safety and Tolerability of Single Ascending Doses of REGN2477
Drugs (2)
- Garetosmab Inhibin beta A chain inhibitor
- Sotatercept Inhibin beta A chain inhibitor