> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/impdh1-f707e053-7546-53bb-906d-11537a2df3e7 > Record changed: 2026-10-13 # IMPDH1 ENSG00000106348 Target class Enzyme Chromosome 7 Approved drugs 6 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 6 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** Yes ## Names **Target name** IMPDH1 **Gene name** Inosine monophosphate dehydrogenase 1 **Gene symbol** IMPDH1 **Previous gene symbols** - RP10 **Protein name** Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) ### Other names (2) - sWSS2608 - LCA11 ## Classification **Gene biotype** Protein coding **Gene family** Inosine monophosphate dehydrogenase family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 172.5 **Tissue specificity (Gini)** 0.332 **Tissue specificity (tau)** 0.786 ## Pathways and interactions **KEGG gene identifiers** - hsa:3614 **Protein interaction confidence** 0.849188 **Protein interaction partners** 64 ### Reactome pathways (4) - R-HSA-6798695 - R-HSA-73817 - R-HSA-9679191 - R-HSA-9748787 ## Genomic location **End position** 128410009 **Start position** 128392277 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000106348 **HGNC ID** HGNC:6052 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6052) **NCBI Gene ID** 3614 **UniProt ID** P20839 ## Cellular location - Cytoplasm . Nucleus . - Cytosol - Rods & Rings ### Publication evidence - PubMed 14766016 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14766016/) ## Tissue expression **Tissue specificity (tau)** 0.785647 **Expression inequality (Gini)** 0.332335 ### Highest expression Expression in transcripts per million **Whole Blood** 172.5 **Spleen** 95.56 **Cells - Cultured fibroblasts** 82.82 **Adipose - Visceral (Omentum)** 79.9 **Adipose - Subcutaneous** 66.89 ### All tissues (54) Expression in transcripts per million - Whole Blood172.5 - Spleen95.56 - Cells - Cultured fibroblasts82.82 - Adipose - Visceral (Omentum)79.9 - Adipose - Subcutaneous66.89 - Lung65.86 - Nerve - Tibial63.23 - Breast - Mammary Tissue60.8 - Stomach57.24 - Prostate56.32 - Bladder52.46 - Pituitary51.99 - Cervix - Endocervix48.81 - Ovary46.66 - Artery - Coronary46.32 - Minor Salivary Gland45.46 - Artery - Aorta45.24 - Vagina43.62 - Esophagus - Muscularis42.62 - Skin - Sun Exposed (Lower leg)42.35 - Esophagus - Gastroesophageal Junction42.09 - Fallopian Tube41.82 - Colon - Sigmoid41.71 - Cervix - Ectocervix41.32 - Testis39.68 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (7) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0034774 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034774) - GO:0035578 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035578) - GO:1904813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904813) ### Molecular functions (3) - GO:0003676 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003676) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0003938 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003938) ## Related records ### Trials (2,861) - 1.Comparison of the Analgesic Effect of Remifentanil Group and Different Dose Groups of Oliceridine in Postoperative Patients Undergoing Cardiac Surgery 2.Exploring the Hemodynamic Effects of Analgesic Regimens With Different Doses of Oliceridine After Cardiac Surgery - 12 Month Athena Study: Everolimus vs. Standard Regimen in de Novo Kidney Transplant Patients - 12 Weeks of Ledipasvir (LDV)/Sofosbuvir (SOF) With Weight-based Ribavirin vs. 24 Weeks of LDV/SOF - 14 vs 24 Weeks HCV Treatment to Genotype 2/3 Patients With Rapid Virological Response - 2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies - 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia - 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome - 24 Month Extension to Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months) in Renal Transplant Patients(Converted to Mycophenolic Acid After 3 Months) in Renal Transplant Patients - 24 Months Follow-up, Two Arm Study to Compare the Cardiovascular Profile in a Regimen With Everolimus + Mycophenolic Acid (MPA) Versus (vs.) a Regimen of CNI+MPA in Maintenance Renal Transplant Recipients - 24 VS 48-WEEK TREATMENT WITH PEG-IFN ALPHA-2A IN PATIENTS WITH GENOTYPE 2/3 CHRONIC HEPATITIS C - 36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent DILI - 48 Weeks Combination Therapy for Patients With HBeAg-negative Chronic Hepatitis B Virus (HBV) Infection - 480 STUDY: Phase 2b Study of Locteron Plus Ribavirin to Treat Hepatitis C Virus (HCV) - 5 Year Long-term Follow up in Pediatric Participants Who Received PegIntron Plus Rebetol in P02538 Part I (P02538 Pt 2) - 5-HTP and Creatine for Depression R33 Phase - 6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients - 90 Y-BC8-DOTA Monoclonal Antibody, Fludarabine Phosphate, and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma - A 24-week Open-label Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD) - A Bioequivalence Study of an Oral Solution of Copegus (Ribavirin) Compared to Copegus Tablets - A Bioequivalence Study to Compare VIMOVO Manufactured at AstraZenca AB to VIMOVO Manufactured by Patheon Pharmaceuticals and Marketed Enteric-coated Naproxen Formulation ### Drugs (9) - AVN-944 Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor - Merimepodib Inosine-5'-monophosphate dehydrogenase 1 inhibitor - Mizoribine Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor - Mycophenolate mofetil Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor - Mycophenolate mofetil hydrochloride Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor - Mycophenolate sodium Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor - Mycophenolic acid Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor - [Ribavirin](https://trialight.com/data/asset/ribavirin-94510534-209a-4906-917e-ae8c153df440.md) Inosine-5'-monophosphate dehydrogenase 1 inhibitor - Thioguanine Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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