> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/il6st-63f1de5a-2d7e-599d-a19a-a6308b40fd13
> Record changed: 2026-11-04

# IL6ST

ENSG00000134352

Target class

Membrane receptor

Chromosome

5

Approved drugs

1

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

IL6ST

**Gene name**

Interleukin 6 cytokine family signal transducer

**Gene symbol**

IL6ST

**Protein name**

Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)

### Other names (4)

- GP130
- CD130
- sGP130
- IL-6RB

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|Fibronectin type III domain containing|Interleukin receptors

**Target class**

Membrane receptor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

214.04

**Tissue specificity (Gini)**

0.342

**Tissue specificity (tau)**

0.736

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3572

**Protein interaction confidence**

0.870018

**Protein interaction partners**

56

### Reactome pathways (5)

- R-HSA-1059683
- R-HSA-6788467
- R-HSA-8984722
- R-HSA-9020956
- R-HSA-9958825

## Genomic location

**End position**

55995022

**Start position**

55935095

**Chromosome**

5

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000134352

**HGNC ID**

HGNC:6021

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6021)

**NCBI Gene ID**

3572

**UniProt ID**

P40189

## Cellular location

- \[Isoform 1\]: Cell membrane
- Single-pass type I membrane protein .
- SUBCELLULAR LOCATION: \[Isoform 2\]: Secreted .
- Golgi apparatus
- Plasma membrane

### Publication evidence (2)

- PubMed 19915009  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19915009/)
- PubMed 24629561  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24629561/)

## Tissue expression

**Tissue specificity (tau)**

0.73623

**Expression inequality (Gini)**

0.342156

### Highest expression

Expression in transcripts per million

**Cells - Cultured fibroblasts**

214.04

**Adipose - Visceral (Omentum)**

117.22

**Lung**

116.88

**Nerve - Tibial**

116.5

**Adipose - Subcutaneous**

113.36

### All tissues (54)

Expression in transcripts per million

- Cells - Cultured fibroblasts214.04
- Adipose - Visceral (Omentum)117.22
- Lung116.88
- Nerve - Tibial116.5
- Adipose - Subcutaneous113.36
- Cervix - Ectocervix108.85
- Artery - Coronary108.36
- Artery - Aorta101.02
- Breast - Mammary Tissue100.24
- Cervix - Endocervix99.6
- Artery - Tibial97.44
- Thyroid96.7
- Fallopian Tube92.44
- Esophagus - Muscularis85.07
- Uterus84.42
- Esophagus - Gastroesophageal Junction78.02
- Ovary77.36
- Bladder76.97
- Vagina69.96
- Spleen65.83
- Colon - Sigmoid65.53
- Adrenal Gland64.88
- Prostate64.8
- Brain - Spinal cord (cervical c-1)64.74
- Minor Salivary Gland54.45

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (23)

- GO:0002675  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002675)
- GO:0002821  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002821)
- GO:0007259  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259)
- GO:0008283  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008283)
- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0010575  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010575)
- GO:0010613  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010613)
- GO:0019221  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221)
- GO:0034097  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034097)
- GO:0038154  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038154)
- GO:0038165  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038165)
- GO:0042102  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042102)
- GO:0043066  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066)
- GO:0043524  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043524)
- GO:0045669  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045669)
- GO:0045747  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045747)
- GO:0048861  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048861)
- GO:0060576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060576)
- GO:0070102  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070102)
- GO:0070106  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070106)
- GO:0070120  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070120)
- GO:0097696  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097696)
- GO:1901731  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901731)

### Cellular components (10)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005896  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005896)
- GO:0005900  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005900)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0045121  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)
- GO:0070110  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070110)
- GO:0140370  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140370)
- GO:7770013  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:7770013)

### Molecular functions (15)

- GO:0004896  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004896)
- GO:0004897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004897)
- GO:0004915  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004915)
- GO:0004923  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004923)
- GO:0004924  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004924)
- GO:0005125  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125)
- GO:0005127  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005127)
- GO:0005138  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005138)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0015026  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026)
- GO:0019838  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019838)
- GO:0019981  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019981)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0045509  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045509)
- GO:0097110  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110)

## Related records

### Trials (560)

- "Comparison of the Efficacy and Safety of Adalimumab to That of Tocilizumab in Severe Uveitis of Behçet's Disease"
- A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005)
- A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)
- A Clinical Trial of MK-6255 to Treat Endometrial and Ovarian Cancer (MK-6255-001)
- A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.
- A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma
- A Dose-Range Finding Study for ALX-0061 Combination Therapy in Subjects With Rheumatoid Arthritis
- A Drug Interaction Study Between Tocilizumab, Methotrexate and Simvastatin on Patients With Rheumatoid Arthritis.
- A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus Erythematosus
- A Long Term Extension Study of WA19926 (NCT01007435) of Tocilizumab (RoActemra/Actemra) in Participants With Early, Moderate to Severe Rheumatoid Arthritis (RA)
- A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Early Moderate to Severe Rheumatoid Arthritis Who Completed Study WA19926
- A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis From France Who Completed WA19977 Core Study
- A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis Who Completed WA19977 Core Study
- A Long-term Extension Study of Tocilizumab (Myeloma Receptor Antibody \[MRA\]) in Patients With Rheumatoid Arthritis
- A Long-Term Extension Study of WA19926 on the Safety of Tocilizumab (RoActemra/Actemra) in Participants With Early Moderate to Severe Rheumatoid Arthritis
- A Long-Term Extension Study of WA22762 and NA25220 of Subcutaneous (SC) Tocilizumab (TCZ) in Moderate to Severe Rheumatoid Arthritis (RA)
- A Long-Term Extension Study of WA22762 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Participants With Moderate to Severe Rheumatoid Arthritis (RA).
- A Long-Term Extension Study of WA22763 and NA25220 of Subcutaneous RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis
- A Long-Term Extension Study to WA19926 (NCT01007435) of Tocilizumab in Participants With Early, Moderate to Severe Rheumatoid Arthritis
- A Long-term Safety Extension Study of Tocilizumab in Brazilian Participants With Rheumatoid Arthritis (RA) Who Completed the Studies ML21530 and MA21488

### Drugs (5)

- Ciliary neurotrophic factor
- Oprelvekin
- Satralizumab IL6Ralpha/GP130 antagonist
- [Tocilizumab](https://trialight.com/data/asset/tocilizumab-58fcf741-84ea-43ec-ab1b-8fc8d306b59d.md)
- Vobarilizumab

---

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