> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/il6r-c7147d9a-d486-5e5b-9263-4bf4c1ee3a1a
> Record changed: 2026-10-13

# IL6R

ENSG00000160712

Target class

Secreted protein

Chromosome

1

Approved drugs

3

Clinical candidates (approved and in development)

5

## Clinical evidence

**Approved drugs**

3

**ClinGen gene-disease validity**

Limited

**Clinical candidates (approved and in development)**

5

## Druggability

**Chemical probe available**

No

## Names

**Target name**

IL6R

**Gene name**

Interleukin 6 receptor

**Gene symbol**

IL6R

**Protein name**

Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) \[Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)\]

### Other names (5)

- CD126
- IL-6R
- IL-1Ra
- IL6RA
- gp80

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|Immunoglobulin like domain containing|Interleukin receptors

**Target class**

Secreted protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Highest tissue expression**

67.24

**Tissue specificity (Gini)**

0.466

**Tissue specificity (tau)**

0.818

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3570

**Protein interaction confidence**

0.822126

**Protein interaction partners**

95

### Reactome pathways (7)

- R-HSA-1059683
- R-HSA-110056
- R-HSA-112411
- R-HSA-6785807
- R-HSA-9616222
- R-HSA-9679191
- R-HSA-9958825

## Genomic location

**End position**

154469450

**Start position**

154405193

**Chromosome**

1

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000160712

**HGNC ID**

HGNC:6019

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6019)

**NCBI Gene ID**

3570

**UniProt ID**

P08887

## Cellular location

- \[Isoform 1\]: Cell membrane
- Single-pass type I membrane protein .
- SUBCELLULAR LOCATION: \[Isoform 2\]: Secreted .
- SUBCELLULAR LOCATION: \[Soluble interleukin-6 receptor subunit alpha\]: Secreted .

### Publication evidence

- PubMed 28060820  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28060820/)

## Tissue expression

**Tissue specificity (tau)**

0.818325

**Expression inequality (Gini)**

0.465862

### Highest expression

Expression in transcripts per million

**Muscle - Skeletal**

67.24

**Whole Blood**

52.69

**Liver**

38.03

**Lung**

29.45

**Esophagus - Muscularis**

27.04

### All tissues (54)

Expression in transcripts per million

- Muscle - Skeletal67.24
- Whole Blood52.69
- Liver38.03
- Lung29.45
- Esophagus - Muscularis27.04
- Fallopian Tube25.91
- Colon - Sigmoid25.73
- Esophagus - Gastroesophageal Junction25.38
- Spleen24
- Uterus23.29
- Small Intestine - Terminal Ileum22.03
- Colon - Transverse19.86
- Nerve - Tibial18.59
- Cervix - Endocervix18.16
- Artery - Tibial17.44
- Ovary16.13
- Adipose - Subcutaneous16.11
- Adipose - Visceral (Omentum)15.19
- Cervix - Ectocervix14.4
- Artery - Coronary13.62
- Pituitary13.57
- Bladder12.16
- Prostate11.66
- Breast - Mammary Tissue11.41
- Vagina11.1

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (19)

- GO:0002384  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002384)
- GO:0002548  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002548)
- GO:0002690  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002690)
- GO:0006953  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006953)
- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0010573  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010573)
- GO:0019221  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221)
- GO:0031018  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031018)
- GO:0032722  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722)
- GO:0032755  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755)
- GO:0034097  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034097)
- GO:0045669  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045669)
- GO:0048661  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048661)
- GO:0050829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050829)
- GO:0070102  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070102)
- GO:0070120  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070120)
- GO:0072126  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072126)
- GO:0097191  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097191)
- GO:0097696  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097696)

### Cellular components (5)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005896  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005896)
- GO:0016324  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324)
- GO:0070110  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070110)

### Molecular functions (8)

- GO:0004897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004897)
- GO:0004915  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004915)
- GO:0005138  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005138)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0019899  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899)
- GO:0019981  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019981)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0070119  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070119)

## Off-target safety

- regulation of transcription factor activity  
### Studies (2)

  - cell-based: LTEA\_HepaRG\_IL6Ris one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Inflammation.
  - cell-based: LTEA\_HepaRG\_IL6Ris one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Inflammation.  
### Biological samples

  - HepaRG, cell line  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (607)

- "Comparison of the Efficacy and Safety of Adalimumab to That of Tocilizumab in Severe Uveitis of Behçet's Disease"
- A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005)
- A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)
- A Clinical Trial of the Efficacy and Safety of Levilimab (BCD-089) in Patients With Severe COVID-19
- A Comparative Study to Observe the Effect of Concomitant Use of Corticosteroid Treatment in Rheumatoid Arthritis (RA) Participants Who Are Treated With a Tumor Necrosis Factor (TNF) Inhibitor or Tocilizumab (TCZ) as Their Second Biological Treatment.
- A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.
- A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma
- A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)
- A Dose-Range Finding Study for ALX-0061 Combination Therapy in Subjects With Rheumatoid Arthritis
- A Drug Interaction Study Between Tocilizumab, Methotrexate and Simvastatin on Patients With Rheumatoid Arthritis.
- A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus Erythematosus
- A Long Term Extension Study of WA19926 (NCT01007435) of Tocilizumab (RoActemra/Actemra) in Participants With Early, Moderate to Severe Rheumatoid Arthritis (RA)
- A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Early Moderate to Severe Rheumatoid Arthritis Who Completed Study WA19926
- A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis From France Who Completed WA19977 Core Study
- A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis Who Completed WA19977 Core Study
- A Long-term Extension Study of Tocilizumab (Myeloma Receptor Antibody \[MRA\]) in Patients With Rheumatoid Arthritis
- A Long-Term Extension Study of WA19926 on the Safety of Tocilizumab (RoActemra/Actemra) in Participants With Early Moderate to Severe Rheumatoid Arthritis
- A Long-Term Extension Study of WA22762 and NA25220 of Subcutaneous (SC) Tocilizumab (TCZ) in Moderate to Severe Rheumatoid Arthritis (RA)
- A Long-Term Extension Study of WA22762 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Participants With Moderate to Severe Rheumatoid Arthritis (RA).
- A Long-Term Extension Study of WA22763 and NA25220 of Subcutaneous RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis

### Drugs (5)

- Levilimab Interleukin-6 receptor alpha subunit inhibitor
- [Sarilumab](https://trialight.com/data/asset/sarilumab-3c9e967c-0b03-4fb4-9d41-9c1c309270be.md) Interleukin-6 receptor alpha subunit antagonist
- Satralizumab IL6Ralpha/GP130 antagonist
- [Tocilizumab](https://trialight.com/data/asset/tocilizumab-58fcf741-84ea-43ec-ab1b-8fc8d306b59d.md) Interleukin-6 receptor alpha subunit inhibitor
- Vobarilizumab Interleukin-6 receptor alpha subunit inhibitor

---

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