> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il6-544ef182-1a34-5e37-8c4c-9f44dc78411c > Record changed: 2026-10-13 # IL6 ENSG00000136244 Target class Secreted protein Chromosome 7 Approved drugs 1 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Target name** IL6 **Gene name** Interleukin 6 **Gene symbol** IL6 **Previous gene symbols** - IFNB2 **Protein name** Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2) ### Other names (4) - IL-6 - BSF2 - HGF - HSF ## Classification **Gene biotype** Protein coding **Gene family** Interleukins|Interleukin 6 type cytokine family **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 34 **Protein localisation evidence grade** Approved **Highest tissue expression** 54.44 **Tissue specificity (Gini)** 0.667 **Tissue specificity (tau)** 0.933 ## Pathways and interactions **KEGG gene identifiers** - hsa:3569 **Protein interaction confidence** 0.826208 **Protein interaction partners** 366 ### Reactome pathways (12) - R-HSA-1059683 - R-HSA-110056 - R-HSA-112411 - R-HSA-2559582 - R-HSA-381426 - R-HSA-6783783 - R-HSA-6785807 - R-HSA-8853884 - R-HSA-8957275 - R-HSA-9660821 - R-HSA-9662834 - R-HSA-9958825 ## Genomic location **End position** 22732002 **Start position** 22725884 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000136244 **HGNC ID** HGNC:6018 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6018) **NCBI Gene ID** 3569 **UniProt ID** P05231 ## Cellular location - Secreted . - Vesicles ### Publication evidence - PubMed 11080265 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11080265/) ## Tissue expression **Tissue specificity (tau)** 0.932735 **Expression inequality (Gini)** 0.666512 ### Highest expression Expression in transcripts per million **Adipose - Visceral (Omentum)** 54.44 **Lung** 29.65 **Fallopian Tube** 13.58 **Breast - Mammary Tissue** 13.06 **Adipose - Subcutaneous** 11.83 ### All tissues (54) Expression in transcripts per million - Adipose - Visceral (Omentum)54.44 - Lung29.65 - Fallopian Tube13.58 - Breast - Mammary Tissue13.06 - Adipose - Subcutaneous11.83 - Artery - Coronary11.58 - Artery - Aorta11.24 - Cells - Cultured fibroblasts8.8 - Nerve - Tibial7.69 - Colon - Sigmoid7.59 - Esophagus - Gastroesophageal Junction6 - Pituitary5.72 - Esophagus - Muscularis5.36 - Kidney - Medulla5.35 - Heart - Atrial Appendage5.28 - Thyroid5.04 - Minor Salivary Gland4.4 - Spleen3.53 - Bladder2.84 - Vagina2.44 - Colon - Transverse2.43 - Stomach2.03 - Prostate2 - Artery - Tibial1.97 - Skin - Not Sun Exposed (Suprapubic)1.87 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (72) - GO:0001781 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001781) - GO:0002384 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002384) - GO:0002446 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002446) - GO:0002548 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002548) - GO:0002639 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002639) - GO:0002675 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002675) - GO:0002690 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002690) - GO:0006953 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006953) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0006959 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006959) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010573 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010573) - GO:0010574 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010574) - GO:0010575 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010575) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010718) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0030168 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030168) - GO:0031175 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031175) - GO:0032722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722) - GO:0032731 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032731) - GO:0032733 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032733) - GO:0032755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755) And 47 more, listed on the interactive page. ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005896 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005896) ### Molecular functions (5) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005138 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005138) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Off-target safety - regulation of transcription factor activity ### Studies (2) - cell-based: LTEA\_HepaRG\_IL6is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Inflammation. - cell-based: LTEA\_HepaRG\_IL6is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Inflammation. ### Biological samples - HepaRG, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of gene expression ### Studies - cell-based: BSK\_CASM3C\_IL6, is one of 14 assay component(s) measured or calculated from the BSK\_CASM3C assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology. ### Biological samples - coronary artery smooth muscle cells, primary cell Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (140) - A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005) - A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006) - A FIH Study to Assess the Safety and Tolerability of NS Intravenous NS101 Infusion - A Phase 1 Clinical Trial of Siltuximab for the Treatment of Antibody-Mediated Rejection After Lung Transplantation - A Phase 1 Study of CNTO 328 (Siltuximab) in Relapsed or Refractory Multiple Myeloma - A Phase 2a Study to Evaluate the Effects of Sirukumab in Subjects With Severe Poorly Controlled Asthma - A Phase 3 Study of Siltuximab or Placebo in Combination With Velcade and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma - A Phase II Study of Siltuximab for CRS/ICANs After CAR-T in Multiple Myeloma - A Phase II Study to Assess the Efficacy and Safety of Olokizumab in Patients With Crohn's Disease - A Pilot Trial of Clazakizumab in Late ABMR - A Randomized Placebo-controlled Safety and Dose-finding Study for the Use of the IL-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection - [A Research Study Looking Into Blood Levels of Three Different Formulations of the Study Medicine Ziltivekimab](https://trialight.com/data/trial/a-research-study-looking-into-blood-levels-of-three-13bf7631-af7a-44aa-8a2f-f7ed42ae81a2.md) - A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation - A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation - [A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation](https://trialight.com/data/trial/a-research-study-to-look-at-how-ziltivekimab-works-compared-199a0302-7cc5-4376-b0dc-ca3c9666c83b.md) - A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack - A Safety and Efficacy Study of CNTO 328 in Patients With B-Cell Non-Hodgkin's Lymphoma, Multiple Myeloma, or Castleman's Disease - A Safety and Efficacy Study of Siltuximab (CNTO 328) in Male Subjects With Metastatic Hormone-Refractory Prostate Cancer (HRPC) - A Safety, Efficacy and Pharmacokinetic Study of Siltuximab (CNTO 328) in Participants With Solid Tumors - A Study Comparing Siltuximab Plus Best Supportive Care to Placebo Plus Best Supportive Care in Anemic Patients With International Prognostic Scoring System Low- or Intermediate-1-Risk Myelodysplastic Syndrome ### Drugs (8) - Clazakizumab Interleukin-6 inhibitor - Elsilimomab Interleukin-6 inhibitor - MRA 003 US Interleukin-6 inhibitor - Olokizumab Interleukin-6 inhibitor - Pacibekitug Interleukin-6 inhibitor - Siltuximab Interleukin-6 antagonist - [Sirukumab](https://trialight.com/data/asset/sirukumab-8f8925da-967a-4b11-9973-96c8d4e7ba86.md) Interleukin-6 inhibitor - [Ziltivekimab](https://trialight.com/data/asset/ziltivekimab-cf6800e3-7dcc-441e-b882-bb8e9e8f278a.md) Interleukin-6 binding agent; Interleukin-6 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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