> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il5-090b670a-6302-57e3-be6b-fdf57248332c > Record changed: 2026-10-13 # IL5 ENSG00000113525 Target class Secreted protein Chromosome 5 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** IL5 **Gene name** Interleukin 5 **Gene symbol** IL5 **Protein name** Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF) ### Other names (3) - IL-5 - EDF - TRF ## Classification **Gene biotype** Protein coding **Gene family** Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 6.72 **Tissue specificity (Gini)** 0.775 **Tissue specificity (tau)** 0.99 ## Pathways and interactions **KEGG gene identifiers** - hsa:3567 **Protein interaction confidence** 0.827698 **Protein interaction partners** 96 ### Reactome pathways (4) - R-HSA-512988 - R-HSA-5673001 - R-HSA-912526 - R-HSA-9976102 ## Genomic location **End position** 132556838 **Start position** 132541445 **Chromosome** 5 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000113525 **HGNC ID** HGNC:6016 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6016) **NCBI Gene ID** 3567 **UniProt ID** P05113 ## Cellular location - Secreted . ### Publication evidence - PubMed 2653458 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2653458/) ## Tissue expression **Tissue specificity (tau)** 0.990089 **Expression inequality (Gini)** 0.774688 ### Highest expression Expression in transcripts per million **Testis** 6.72 **Brain - Cerebellum** 0.18 **Ovary** 0.18 **Cervix - Endocervix** 0.17 **Uterus** 0.17 ### All tissues (54) Expression in transcripts per million - Testis6.72 - Brain - Cerebellum0.18 - Ovary0.18 - Cervix - Endocervix0.17 - Uterus0.17 - Artery - Aorta0.14 - Pituitary0.14 - Brain - Cerebellar Hemisphere0.13 - Nerve - Tibial0.12 - Artery - Tibial0.11 - Artery - Coronary0.11 - Esophagus - Gastroesophageal Junction0.11 - Fallopian Tube0.1 - Cervix - Ectocervix0.1 - Colon - Sigmoid0.1 - Vagina0.09 - Brain - Spinal cord (cervical c-1)0.09 - Thyroid0.08 - Esophagus - Muscularis0.08 - Brain - Hypothalamus0.08 - Small Intestine - Terminal Ileum0.07 - Bladder0.07 - Brain - Caudate (basal ganglia)0.07 - Cells - EBV-transformed lymphocytes0.06 - Lung0.06 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0038043 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038043) - GO:0046427 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046427) - GO:0071803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071803) ### Cellular components - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) ### Molecular functions (3) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005137 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005137) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (144) - A Multi-center, Open-label Extension, Safety Study of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES) From Study 200622 - A Phase 3a, Repeat Dose, Open-label, Long-term Safety Study of Mepolizumab in Asthmatic Subjects - A Pilot Study of the Use of 129Xe and 1H MRI to Measure the Modulation of Eosinophil-Related Inflammation by Mepolizumab In COPD - A Pragmatic Study to Investigate the Efficacy and Safety of Mepolizumab in Severe Uncontrolled Asthma in Brazil - A Real-world, Head-to-head Comparison of Dupilumab Versus Mepolizumab in Danish Patients With Chronic Rhinosinusitis With Nasal Polyps - A Safety and Efficacy Study of Mepolizumab in Subjects With Severe Asthma - A Study of Depemokimab in Participants of 6 to 11 Years of Age - A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma - A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype - A Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype - A Study of Reslizumab in Patients 12 Years of Age and Older With Severe Eosinophilic Asthma - A Study on the Effect of Mepolizumab Therapy on Daily Physical Activity of Patients With Severe Eosinophilic Asthma - A Study to Compare the Pharmacokinetics (PK) of Depemokimab When Delivered With a Safety Syringe Device (SSD) or an Autoinjector in Healthy Adult Participants - A Study to Determine Long-term Safety of Mepolizumab in Asthmatic Subjects - A Study to Evaluate the Efficacy and Safety of Reslizumab (0.3 or 3.0 mg/kg) as Treatment for Patients (12-75 Years of Age) With Eosinophilic Asthma - A Study to Evaluate the Efficacy and Safety of Reslizumab (3.0 mg/kg) in the Reduction of Clinical Asthma Exacerbations in Patients (12-75 Years of Age) With Eosinophilic Asthma - A Study to Evaluate the Efficacy and Safety of Reslizumab in Patients With Eosinophilic Asthma - A Study to Evaluate the Efficacy and Safety of SHR-1703 in Subjects With Eosinophilic Granulomatosis With Polyangiitis （EGPA） - A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis - A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children ### Drugs (3) - [Depemokimab](https://trialight.com/data/asset/depemokimab-93726dca-0ebb-4516-bb21-7b9d28cf32bb.md) Interleukin-5 inhibitor - [Mepolizumab](https://trialight.com/data/asset/mepolizumab-d54dc5ae-b70d-484f-859d-18a4f3f7efa5.md) Interleukin-5 inhibitor - Reslizumab Interleukin-5 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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