> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il33-12189ad8-d2c3-5ad3-87f8-90f0c4b3ef78 > Record changed: 2026-10-13 # IL33 ENSG00000137033 Target class Secreted protein Chromosome 9 Approved drugs 0 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** IL33 **Gene name** Interleukin 33 **Gene symbol** IL33 **Previous gene symbols** - C9orf26 **Protein name** Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) \[Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)\] ### Other names (4) - DVS27 - DKFZp586H0523 - NF-HEV - IL1F11 ## Classification **Gene biotype** Protein coding **Gene family** Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Supported **Highest tissue expression** 86.35 **Tissue specificity (Gini)** 0.496 **Tissue specificity (tau)** 0.772 ## Pathways and interactions **KEGG gene identifiers** - hsa:90865 **Protein interaction confidence** 0.828614 **Protein interaction partners** 44 ### Reactome pathways (4) - R-HSA-1257604 - R-HSA-5689880 - R-HSA-6811558 - R-HSA-9014843 ## Genomic location **End position** 6257983 **Start position** 6215136 **Chromosome** 9 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000137033 **HGNC ID** HGNC:16028 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:16028) **NCBI Gene ID** 90865 **UniProt ID** O95760 ## Cellular location - Nucleus . Chromosome . Cytoplasm . Cytoplasmic vesicle, secretory vesicle . Secreted . Note=Secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore following cleavage by CELA1 (PubMed:35794369). Associates with heterochromatin and mitotic chromosomes (PubMed:17185418). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 - it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). . - Nucleoplasm - Vesicles ### Publication evidence (9) - PubMed 12819012 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12819012/) - PubMed 17185418 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17185418/) - PubMed 18787100 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18787100/) - PubMed 18836528 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18836528/) - PubMed 21734074 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21734074/) - PubMed 32272059 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32272059/) - PubMed 22215666 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22215666/) - PubMed 19465481 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19465481/) - PubMed 35794369 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35794369/) ## Tissue expression **Tissue specificity (tau)** 0.77232 **Expression inequality (Gini)** 0.49594 ### Highest expression Expression in transcripts per million **Artery - Coronary** 86.35 **Esophagus - Muscularis** 60.07 **Artery - Aorta** 59.66 **Cervix - Endocervix** 56.43 **Cervix - Ectocervix** 51.93 ### All tissues (54) Expression in transcripts per million - Artery - Coronary86.35 - Esophagus - Muscularis60.07 - Artery - Aorta59.66 - Cervix - Endocervix56.43 - Cervix - Ectocervix51.93 - Esophagus - Gastroesophageal Junction48.07 - Uterus44.9 - Fallopian Tube43.79 - Adipose - Visceral (Omentum)42.91 - Bladder42.3 - Lung39.14 - Stomach34.64 - Adipose - Subcutaneous34.42 - Colon - Sigmoid33.58 - Vagina32.9 - Breast - Mammary Tissue30.71 - Heart - Atrial Appendage29.73 - Artery - Tibial29.61 - Prostate26.06 - Nerve - Tibial24.58 - Thyroid22.47 - Skin - Not Sun Exposed (Suprapubic)20.67 - Small Intestine - Terminal Ileum18.09 - Minor Salivary Gland16.74 - Brain - Amygdala13.98 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0032722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722) - GO:0043032 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043032) - GO:0106015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106015) - GO:0150078 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150078) ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005694) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) ### Molecular functions (2) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (25) - A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Adult Japanese Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps - A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps - A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps - A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti--IL-33 mAb) in Participants With Chronic Rhinosinusitis Without Nasal Polyps - [A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis](https://trialight.com/data/trial/a-proof-of-concept-study-to-assess-the-efficacy-safety-and-2e3a8196-291f-4149-a108-d5bdb2fb69dd.md) - A Study of Different Injectable Formulations of LY3375880 in Healthy Participants - A Study of Intravenously or Subcutaneously Administered REGN3500 in Healthy Adult Subjects - A Study of LY3375880 in Adults With Moderate-to-Severe Atopic Dermatitis - A Study of LY3375880 in Healthy Participants - A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD - An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps - Efficacy and Safety of REGN3500 Monotherapy and Combination of REGN3500 Plus Dupilumab in Adult Patients With Moderate-to-Severe Atopic Dermatitis - Efficacy, Safety, and Pharmacokinetic Profile of Etokimab (ANB020) in Adult Participants With Moderate-to-Severe Atopic Dermatitis - Efficacy, Safety, and Pharmacokinetic Profiles of REGN3500 Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis - Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) - Evaluation of SAR440340 and as Combination Therapy With Dupilumab in Moderate-to-Severe Asthma Participants - Mechanistic Study of the Effect of Itepekimab on Airway Inflammation in Patients With COPD - Pharmacokinetic Study to Compare Itepekimab Exposure When Administered With an Autoinjector Versus Prefilled Syringe - Proof of Concept Study to Investigate Etokimab (ANB020) Activity in Adult Participants With Severe Eosinophilic Asthma - Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD) ### Drugs (3) - Etokimab Interleukin-33 binding agent - [Itepekimab](https://trialight.com/data/asset/itepekimab-f9c04283-c91c-4c3d-a8c1-3e4e957c4d6f.md) Interleukin-33 inhibitor - Torudokimab Interleukin-33 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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