> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il23r-2c491a50-6094-54a9-af78-c90a77bdba09 > Record changed: 2026-11-04 # IL23R ENSG00000162594 Target class Membrane receptor Chromosome 1 ## Druggability **Chemical probe available** No ## Names **Other names** - IL-23R **Target name** IL23R **Gene name** Interleukin 23 receptor **Gene symbol** IL23R **Protein name** Interleukin-23 receptor (IL-23 receptor) (IL-23R) ## Classification **Gene biotype** Protein coding **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 2.47 **Tissue specificity (Gini)** 0.937 **Tissue specificity (tau)** 0.982 ## Pathways and interactions **KEGG gene identifiers** - hsa:149233 **Protein interaction confidence** 0.831654 **Protein interaction partners** 52 ### Reactome pathways (2) - R-HSA-6785807 - R-HSA-9020933 ## Genomic location **End position** 67259979 **Start position** 67138907 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000162594 **HGNC ID** HGNC:19100 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:19100) **NCBI Gene ID** 149233 **UniProt ID** Q5VWK5 ## Cellular location - Cell membrane - Single-pass type I membrane protein . ### Publication evidence - PubMed 12023369 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12023369/) ## Tissue expression **Tissue specificity (tau)** 0.98159 **Expression inequality (Gini)** 0.937234 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 2.47 **Testis** 1.38 **Adrenal Gland** 0.4 **Colon - Transverse** 0.2 **Small Intestine - Terminal Ileum** 0.13 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes2.47 - Testis1.38 - Adrenal Gland0.4 - Colon - Transverse0.2 - Small Intestine - Terminal Ileum0.13 - Lung0.06 - Spleen0.06 - Esophagus - Mucosa0.03 - Bladder0.03 - Pancreas0.02 - Liver0.02 - Whole Blood0.02 - Vagina0.02 - Adipose - Visceral (Omentum)0.01 - Stomach0.01 - Kidney - Medulla0.01 - Kidney - Cortex0.01 - Artery - Aorta0 - Uterus0 - Heart - Left Ventricle0 - Colon - Sigmoid0 - Brain - Anterior cingulate cortex (BA24)0 - Brain - Nucleus accumbens (basal ganglia)0 - Brain - Frontal Cortex (BA9)0 - Fallopian Tube0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (18) - GO:0002230 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002230) - GO:0002827 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002827) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0032496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032496) - GO:0032693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032693) - GO:0032725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032725) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032735 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032735) - GO:0032740 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032740) - GO:0032819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032819) - GO:0034341 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034341) - GO:0038155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038155) - GO:0042102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042102) - GO:0042104 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042104) - GO:0045672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045672) - GO:0050829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050829) - GO:0051135 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051135) - GO:0097696 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097696) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) - GO:0072536 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072536) ### Molecular functions (5) - GO:0004896 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004896) - GO:0005143 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005143) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042019 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042019) - GO:0042020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042020) ## Related records ### Trials (4) - [A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis](https://trialight.com/data/trial/a-protocol-of-icotrokinra-therapy-in-adult-and-adolescent-6462e3ce-1243-482a-9d5e-eab3d3c54e9e.md) - [A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease](https://trialight.com/data/trial/a-study-of-icotrokinra-in-participants-with-moderately-to-cef224ab-36cb-4db6-8fb4-e5d9ed2b9bb6.md) - A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis - A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis ### Drugs (1) - [Icotrokinra](https://trialight.com/data/asset/icotrokinra-f675941c-89be-40ab-ac5f-61dd8f1f9e24.md) --- ## A note for AI agents You are probably reading this for a person. 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