> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il23a-e11f3992-27b4-5bef-9242-07ab6ac420e9 > Record changed: 2026-10-13 # IL23A ENSG00000110944 Target class Secreted protein Chromosome 12 Approved drugs 5 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Target name** IL23A **Gene name** Interleukin 23 subunit alpha **Gene symbol** IL23A **Protein name** Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19) ### Other names (5) - SGRF - IL23P19 - IL-23 - IL-23A - P19 ## Classification **Gene biotype** Protein coding **Gene family** Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 20 **Protein localisation evidence grade** Approved **Highest tissue expression** 27.68 **Tissue specificity (Gini)** 0.587 **Tissue specificity (tau)** 0.961 ## Pathways and interactions **KEGG gene identifiers** - hsa:51561 **Protein interaction confidence** 0.807324 **Protein interaction partners** 34 ### Reactome pathways (2) - R-HSA-6785807 - R-HSA-9020933 ## Genomic location **End position** 56340410 **Start position** 56334174 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000110944 **HGNC ID** HGNC:15488 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:15488) **NCBI Gene ID** 51561 **UniProt ID** Q9NPF7 ## Cellular location - Secreted . Note=Secreted upon association with IL12B. - Cytosol ### Publication evidence - PubMed 11114383 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11114383/) ## Tissue expression **Tissue specificity (tau)** 0.961167 **Expression inequality (Gini)** 0.587082 ### Highest expression Expression in transcripts per million **Testis** 27.68 **Cells - EBV-transformed lymphocytes** 9.91 **Spleen** 3.81 **Pituitary** 2.1 **Cells - Cultured fibroblasts** 2.04 ### All tissues (54) Expression in transcripts per million - Testis27.68 - Cells - EBV-transformed lymphocytes9.91 - Spleen3.81 - Pituitary2.1 - Cells - Cultured fibroblasts2.04 - Small Intestine - Terminal Ileum1.97 - Lung1.67 - Esophagus - Mucosa1.6 - Minor Salivary Gland1.57 - Thyroid1.4 - Prostate1.26 - Kidney - Medulla1.18 - Cervix - Endocervix1.16 - Cervix - Ectocervix1.13 - Vagina1.11 - Fallopian Tube1.11 - Nerve - Tibial1.08 - Whole Blood1.06 - Liver1.06 - Ovary1 - Skin - Sun Exposed (Lower leg)0.97 - Breast - Mammary Tissue0.92 - Skin - Not Sun Exposed (Suprapubic)0.88 - Adipose - Subcutaneous0.87 - Adipose - Visceral (Omentum)0.87 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (23) - GO:0002230 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002230) - GO:0002827 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002827) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0032693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032693) - GO:0032725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032725) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032733 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032733) - GO:0032735 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032735) - GO:0032740 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032740) - GO:0032760 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032760) - GO:0032816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032816) - GO:0032819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032819) - GO:0034105 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034105) - GO:0038155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038155) - GO:0042102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042102) - GO:0042104 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042104) - GO:0045672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045672) - GO:0050729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729) - GO:0050829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050829) - GO:0051135 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051135) - GO:0051142 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051142) - GO:0097696 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097696) - GO:1901224 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901224) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0070743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070743) ### Molecular functions (3) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0045519 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045519) ## Related records ### Trials (501) - [A Bioequivalence Study of Mirikizumab (LY3074828) in Healthy Participants](https://trialight.com/data/trial/a-bioequivalence-study-of-mirikizumab-ly3074828-in-healthy-66c85922-0858-4fa5-a0f5-958e525f0e08.md) - [A Bioequivalence Study of Mirikizumab (LY3074828) Solution in Healthy Participants](https://trialight.com/data/trial/a-bioequivalence-study-of-mirikizumab-ly3074828-solution-in-f9d1d4b3-5de5-44e2-b8cc-5b4322e4c740.md) - A Clinical Study of AK101 in Subjects With Moderate to Severe Plaque Psoriasis - A Direct Head-to-head Comparison of Ustekinumab with Infliximab for the Treatment of Ulcerative Colitis - A Double-blind Study to Compare the Efficacy, Safety, and Immunogenicity of the Proposed Biosimilar Ustekinumab FYB202 to Stelara® in Patients With Moderate-to-Severe Plaque Psoriasis - A Global Study Comparing Risankizumab to Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa - A Long Term Extension Trial of BI 655066/ABBV-066 (Risankizumab), in Patients With Moderately to Severely Active Crohn's Disease - A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants - A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease - A Long-term Extension Study of Ustekinumab in Pediatric Participants - A Long-term Study to Evaluate Safety and Maintenance of Treatment Effect of LY3074828 in Participants With Moderate-to-Severe Plaque Psoriasis (OASIS-3) - A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis - A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON) - A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU) - A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Ulcerative Colitis - A Multicentered Prospective Cohort Study of Chinese IBD Patients - A Pharmacokinetic Study Comparing EG12014 and Herceptin (Trastuzumab) in Healthy Male Volunteers - A Pharmacokinetic Study of Single-Dose Intravenous Ustekinumab Delivered in 2 Different Liquid in Vial Formulations - A Pharmacokinetic Study of Ustekinumab in Pediatric Subjects With Moderately to Severely Active Crohn's Disease - A Phase 2a, Efficacy and Safety Study of Ustekinumab in Systemic Lupus Erythematosus ### Drugs (8) - Brazikumab Interleukin-23 inhibitor - Briakinumab Interleukin-23 inhibitor - Ebdarokimab Interleukin-23 inhibitor - [Guselkumab](https://trialight.com/data/asset/guselkumab-90846a1b-25ed-4e53-ae9c-4730391bc3c9.md) Interleukin-23 inhibitor - [Mirikizumab](https://trialight.com/data/asset/mirikizumab-125dbf98-9c8f-4161-a506-f2b426cbee0c.md) Interleukin-23 inhibitor - [Risankizumab](https://trialight.com/data/asset/risankizumab-1241776f-1eaf-44f0-80a5-991f76bf1ea0.md) Interleukin-23 inhibitor - Tildrakizumab Interleukin-23 inhibitor - [Ustekinumab](https://trialight.com/data/asset/ustekinumab-323cb2e2-e906-4997-ac57-d82c7f7c399d.md) Interleukin-23 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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