> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il1rl1-dc683f4d-5537-5bcc-afbb-ef461a99c4ff > Record changed: 2026-10-13 # IL1RL1 ENSG00000115602 Target class Enzyme Chromosome 2 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** IL1RL1 **Gene name** Interleukin 1 receptor like 1 **Gene symbol** IL1RL1 **Protein name** Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2) ### Other names (7) - ST2 - FIT-1 - ST2L - ST2V - DER4 - T1 - IL33R ## Classification **Gene biotype** Protein coding **Gene family** I-set domain containing|Interleukin receptors|TIR domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 39 **Protein localisation evidence grade** Supported **Highest tissue expression** 134.57 **Tissue specificity (Gini)** 0.733 **Tissue specificity (tau)** 0.969 ## Pathways and interactions **KEGG gene identifiers** - hsa:9173 **Protein interaction confidence** 0.855688 **Protein interaction partners** 16 ### Reactome pathways (3) - R-HSA-1257604 - R-HSA-6811558 - R-HSA-9014843 ## Genomic location **End position** 102352353 **Start position** 102311502 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000115602 **HGNC ID** HGNC:5998 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5998) **NCBI Gene ID** 9173 **UniProt ID** Q01638 ## Cellular location - \[Isoform C\]: Cell membrane. - SUBCELLULAR LOCATION: \[Isoform B\]: Secreted. - SUBCELLULAR LOCATION: Cell membrane - Single-pass type I membrane protein . - Cytosol - Focal adhesion sites - Plasma membrane ### Publication evidence - PubMed 11478810 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11478810/) ## Tissue expression **Tissue specificity (tau)** 0.968879 **Expression inequality (Gini)** 0.733199 ### Highest expression Expression in transcripts per million **Lung** 134.57 **Kidney - Cortex** 51.26 **Adrenal Gland** 17.64 **Kidney - Medulla** 15.5 **Adipose - Visceral (Omentum)** 13.39 ### All tissues (54) Expression in transcripts per million - Lung134.57 - Kidney - Cortex51.26 - Adrenal Gland17.64 - Kidney - Medulla15.5 - Adipose - Visceral (Omentum)13.39 - Stomach12.24 - Adipose - Subcutaneous8.96 - Heart - Atrial Appendage6.88 - Breast - Mammary Tissue6.44 - Small Intestine - Terminal Ileum6.07 - Bladder4.93 - Esophagus - Gastroesophageal Junction3.9 - Esophagus - Muscularis3.9 - Artery - Coronary3.78 - Artery - Aorta3.62 - Skin - Sun Exposed (Lower leg)3.61 - Heart - Left Ventricle3.53 - Cells - Cultured fibroblasts3.41 - Fallopian Tube3.25 - Thyroid2.94 - Prostate2.94 - Nerve - Tibial2.88 - Vagina2.86 - Uterus2.8 - Colon - Transverse2.72 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0038172 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038172) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0002114 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002114) - GO:0004896 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004896) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (10) - A First-in-Human, Double Blind, Single Dose Study in Healthy Subjects and Subjects With Mild Atopic Asthma. - A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Moderate to Severe Atopic Dermatitis - A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Uncontrolled Severe Asthma - [A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease](https://trialight.com/data/trial/a-study-to-evaluate-astegolimab-in-participants-with-chronic-8e6922e8-89e1-4070-b3b2-33d3efcab415.md) - A Study to Evaluate the Effect of Injection Site on PK of Astegolimab in Healthy Subjects - A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease - [A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)](https://trialight.com/data/trial/a-study-to-evaluate-the-long-term-safety-of-astegolimab-in-1671bf48-3835-4354-b78c-ff5ccbb9fc26.md) - A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia - A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polyps - Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP) ### Drugs (1) - [Astegolimab](https://trialight.com/data/asset/astegolimab-29ef649e-0460-44f8-91da-cd089a34950c.md) IL-33 receptor (ST2) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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