> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il1rap-140792ff-8cd2-58b9-81bd-4952f51389f6 > Record changed: 2026-10-13 # IL1RAP ENSG00000196083 Target class Enzyme Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** IL1RAP **Gene name** Interleukin 1 receptor accessory protein **Gene symbol** IL1RAP **Protein name** Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3) ### Other names (3) - IL-1RAcP - IL1R3 - C3orf13 ## Classification **Gene biotype** Protein coding **Gene family** Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 42 **Protein localisation evidence grade** Approved **Highest tissue expression** 13.57 **Tissue specificity (Gini)** 0.46 **Tissue specificity (tau)** 0.826 ## Pathways and interactions **KEGG gene identifiers** - hsa:3556 **Protein interaction confidence** 0.917864 **Protein interaction partners** 22 ## Genomic location **End position** 190659750 **Start position** 190514051 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000196083 **HGNC ID** HGNC:5995 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5995) **NCBI Gene ID** 3556 **UniProt ID** Q9NPH3 ## Cellular location - \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein. - SUBCELLULAR LOCATION: \[Isoform 2\]: Secreted. - SUBCELLULAR LOCATION: \[Isoform 3\]: Secreted. - Cytosol - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.826268 **Expression inequality (Gini)** 0.460348 ### Highest expression Expression in transcripts per million **Liver** 13.57 **Whole Blood** 9.54 **Esophagus - Mucosa** 7.83 **Lung** 7.24 **Skin - Not Sun Exposed (Suprapubic)** 6.96 ### All tissues (54) Expression in transcripts per million - Liver13.57 - Whole Blood9.54 - Esophagus - Mucosa7.83 - Lung7.24 - Skin - Not Sun Exposed (Suprapubic)6.96 - Skin - Sun Exposed (Lower leg)6.5 - Cells - Cultured fibroblasts5.3 - Vagina5.1 - Fallopian Tube4.06 - Minor Salivary Gland3.47 - Artery - Coronary3.24 - Nerve - Tibial3.17 - Uterus3.05 - Adipose - Visceral (Omentum)3.03 - Spleen3.02 - Artery - Tibial2.77 - Breast - Mammary Tissue2.52 - Artery - Aorta2.45 - Bladder2.38 - Adipose - Subcutaneous2.35 - Prostate2.17 - Cervix - Ectocervix2.17 - Cervix - Endocervix2.16 - Brain - Frontal Cortex (BA9)1.95 - Ovary1.87 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) - GO:0038172 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038172) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0065003 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0065003) - GO:0070498 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070498) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) ## Related records ### Trials (51) - A First-in-Human, Double Blind, Single Dose Study in Healthy Subjects and Subjects With Mild Atopic Asthma. - A Study in Patients With Atopic Eczema to Test How Effective BI 655130 is and How Well it is Tolerated - A Study in Patients With Mild or Moderate Ulcerative Colitis Who Take a TNF Inhibitor. The Study Investigates Whether Bowel Inflammation Improves When Patients Take BI 655130 in Addition to Their Current Therapy - A Study Investigating Long-term Treatment With Spesolimab in People With a Skin Disease Called Hidradenitis Suppurativa Who Completed a Previous Clinical Trial - A Study Testing How BI 655130 Works in Patients With Fistulizing Crohn's Disease - A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Moderate to Severe Atopic Dermatitis - A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Uncontrolled Severe Asthma - [A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease](https://trialight.com/data/trial/a-study-to-evaluate-astegolimab-in-participants-with-chronic-8e6922e8-89e1-4070-b3b2-33d3efcab415.md) - A Study to Evaluate of the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Acneiform Rash - A Study to Evaluate the Effect of Injection Site on PK of Astegolimab in Healthy Subjects - A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease - A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Generalized Pustular Psoriasis - A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Palmoplantar Pustulosis - A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Acne Vulgaris - A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Hidradenitis Suppurativa - A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Ichthyosis - [A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)](https://trialight.com/data/trial/a-study-to-evaluate-the-long-term-safety-of-astegolimab-in-1671bf48-3835-4354-b78c-ff5ccbb9fc26.md) - A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia - A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polyps - A Study to Test How Effective and Safe Different Doses of BI 655130 Are in Patients With a Moderate to Severe Form of the Skin Disease Palmoplantar Pustulosis ### Drugs (3) - [Astegolimab](https://trialight.com/data/asset/astegolimab-29ef649e-0460-44f8-91da-cd089a34950c.md) IL-33 receptor (ST2) inhibitor - Imsidolimab IL36 receptor antagonist - Spesolimab IL36 receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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