> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/il1r1-fd2f6b61-a37d-5c74-a0ab-8e599b34b339
> Record changed: 2026-10-13

# IL1R1

ENSG00000115594

Target class

Membrane receptor

Chromosome

2

Approved drugs

1

Clinical candidates (approved and in development)

3

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

3

## Druggability

**Chemical probe available**

No

## Names

**Target name**

IL1R1

**Gene name**

Interleukin 1 receptor type 1

**Gene symbol**

IL1R1

**Protein name**

Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) \[Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)\]

### Other names (2)

- D2S1473
- CD121A

### Previous gene symbols (2)

- IL1R
- IL1RA

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|I-set domain containing|Interleukin receptors|TIR domain containing

**Target class**

Membrane receptor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

188.51

**Tissue specificity (Gini)**

0.521

**Tissue specificity (tau)**

0.817

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3554

**Protein interaction confidence**

0.839266

**Protein interaction partners**

64

### Reactome pathways (3)

- R-HSA-6783783
- R-HSA-9020702
- R-HSA-9679191

## Genomic location

**End position**

102179874

**Start position**

102063933

**Chromosome**

2

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000115594

**HGNC ID**

HGNC:5993

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5993)

**NCBI Gene ID**

3554

**UniProt ID**

P14778

## Cellular location

- Membrane
- Single-pass type I membrane protein . Cell membrane . Secreted .
- Cytosol
- Nucleoplasm
- Plasma membrane
- Vesicles

### Publication evidence

- PubMed 8142597  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8142597/)

## Tissue expression

**Tissue specificity (tau)**

0.816701

**Expression inequality (Gini)**

0.520578

### Highest expression

Expression in transcripts per million

**Cells - Cultured fibroblasts**

188.51

**Lung**

141.39

**Adipose - Visceral (Omentum)**

140.12

**Adipose - Subcutaneous**

112.56

**Breast - Mammary Tissue**

82.34

### All tissues (54)

Expression in transcripts per million

- Cells - Cultured fibroblasts188.51
- Lung141.39
- Adipose - Visceral (Omentum)140.12
- Adipose - Subcutaneous112.56
- Breast - Mammary Tissue82.34
- Prostate76.58
- Thyroid74.71
- Cervix - Endocervix67.33
- Fallopian Tube63.82
- Artery - Coronary63.36
- Adrenal Gland59.01
- Artery - Aorta58.04
- Bladder54.89
- Cervix - Ectocervix53.46
- Vagina51.05
- Skin - Sun Exposed (Lower leg)42.54
- Esophagus - Gastroesophageal Junction42.17
- Spleen42.16
- Skin - Not Sun Exposed (Suprapubic)41.39
- Artery - Tibial39.5
- Small Intestine - Terminal Ileum38.47
- Uterus37.75
- Esophagus - Muscularis36.87
- Minor Salivary Gland36.44
- Colon - Sigmoid32.48

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (9)

- GO:0006955  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955)
- GO:0007166  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166)
- GO:0010641  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010641)
- GO:0032729  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729)
- GO:0043123  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123)
- GO:0051897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897)
- GO:0070498  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070498)
- GO:0070555  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070555)
- GO:2000556  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000556)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)

### Molecular functions (5)

- GO:0004888  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888)
- GO:0004908  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004908)
- GO:0004909  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004909)
- GO:0005161  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005161)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (285)

- "IL-1β Blockade to Prevent Immunothrombosis in Recipients of a Pancreatic Organ"
- 3 Anthracyclines, 2 Types of Consolidation With Different ARA-C Doses and Maintenance in Adult Acute Myeloid Leukemia
- A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease
- A Dose-Block Randomized, Placebo Controlled (Double-blind), Active Controlled(Open-label), Dose-escalation Study
- A Dose-Escalation to Rash Study of Tarceva (Erlotinib) Plus Gemcitabine in Patients With Metastatic Pancreatic Cancer
- A Multiple Dose Study to Evaluate Subcutaneous AMG 108 in Subjects With Rheumatoid Arthritis
- A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity
- A Pilot Study to Assess the Immunogenicity and Reactogenicity of High Versus Standard Dose TIV
- A Pilot Study Using Anakinra/Kineret for the Treatment of Patients With Severe Atopic Dermatitis
- A Pilot, Prospective, Non-randomized Evaluation of the Safety of Anakinra Plus Standard Chemotherapy
- A Randomized Double Blind, Placebo Controlled Trial With AMG 108 in Patients With Type 2 Diabetes Mellitus
- A Rheumatoid Arthritis (RA) Study Treating Signs and Symptoms of RA in People With RA & Receiving Methotrexate
- A Safety and Efficacy Study of Concomitant Administration of ChAd63/MVA ME-TRAP + RTS,S
- A Safety Study of SGN-CD33A in Combination With Standard-of-care in Patients With AML
- A Study in Patients With COVID-19 and Respiratory Distress Not Requiring Mechanical Ventilation, to Compare Standard-of-care With Anakinra and Tocilizumab Treatment The Immunomodulation-CoV Assessment (ImmCoVA) Study
- A Study of Anakinra in Japanese Patients With Still's Disease (SJIA and AOSD)
- A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy
- A Study of CART-PSMA-TGFβRDN in Patients With Metastatic Castration Resistant Prostate Cancer
- A Study of CellCept (Mycophenolate Mofetil) Combined With Tacrolimus and Corticosteroids in Kidney Transplant Patients.
- A Study of CellCept (Mycophenolate Mofetil) in Combination Therapy in Liver Transplant Patients.

### Drugs (3)

- AMG-108 Interleukin-1 receptor antagonist
- [Anakinra](https://trialight.com/data/asset/anakinra-2c0352ee-cb20-46c5-bd87-6350d9024e75.md) Interleukin-1 receptor antagonist
- MEDI-8968 Interleukin-1 receptor inhibitor

---

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