> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il1b-a893351e-84c8-5959-8b42-db764a8a634f > Record changed: 2026-10-13 # IL1B ENSG00000125538 Target class Secreted protein Chromosome 2 Approved drugs 2 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** IL1B **Gene name** Interleukin 1 beta **Gene symbol** IL1B **Protein name** Interleukin-1 beta (IL-1 beta) (Catabolin) ### Other names (3) - IL1F2 - IL-1B - IL1-BETA ## Classification **Gene biotype** Protein coding **Gene family** Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 20 **Highest tissue expression** 24.53 **Tissue specificity (Gini)** 0.669 **Tissue specificity (tau)** 0.949 ## Pathways and interactions **KEGG gene identifiers** - hsa:3553 **Protein interaction confidence** 0.82287 **Protein interaction partners** 291 ### Reactome pathways (9) - R-HSA-448706 - R-HSA-5620971 - R-HSA-5660668 - R-HSA-6783783 - R-HSA-6785807 - R-HSA-9020702 - R-HSA-9660826 - R-HSA-9960519 - R-HSA-9960525 ## Genomic location **End position** 112836816 **Start position** 112829751 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000125538 **HGNC ID** HGNC:5992 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5992) **NCBI Gene ID** 3553 **UniProt ID** P01584 ## Cellular location - Cytoplasm, cytosol . Secreted . Lysosome . Secreted, extracellular exosome . Note=The precursor is cytosolic (PubMed:15192144). In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). . ### Publication evidence (6) - PubMed 15192144 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15192144/) - PubMed 11728343 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11728343/) - PubMed 33883744 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33883744/) - PubMed 24201029 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24201029/) - PubMed 33377178 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33377178/) - PubMed 32272059 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32272059/) ## Tissue expression **Tissue specificity (tau)** 0.94878 **Expression inequality (Gini)** 0.66863 ### Highest expression Expression in transcripts per million **Whole Blood** 24.53 **Spleen** 15.09 **Lung** 6.91 **Stomach** 4.53 **Brain - Spinal cord (cervical c-1)** 2.53 ### All tissues (54) Expression in transcripts per million - Whole Blood24.53 - Spleen15.09 - Lung6.91 - Stomach4.53 - Brain - Spinal cord (cervical c-1)2.53 - Fallopian Tube2.51 - Adipose - Visceral (Omentum)2.47 - Cells - EBV-transformed lymphocytes2.21 - Small Intestine - Terminal Ileum1.65 - Esophagus - Mucosa1.56 - Artery - Coronary1.54 - Kidney - Medulla1.52 - Pituitary1.48 - Brain - Hypothalamus1.23 - Artery - Aorta1.16 - Bladder1.11 - Brain - Substantia nigra1.11 - Minor Salivary Gland1.06 - Testis1.06 - Colon - Transverse1.02 - Brain - Amygdala0.87 - Prostate0.86 - Cervix - Endocervix0.74 - Adrenal Gland0.73 - Brain - Hippocampus0.72 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (60) - GO:0002711 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002711) - GO:0006915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0007566 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007566) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010573 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010573) - GO:0010575 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010575) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010641 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010641) - GO:0010718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010718) - GO:0010744 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010744) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0030213 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030213) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0030949 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030949) - GO:0031394 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031394) - GO:0032496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032496) - GO:0032725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032725) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032743) - GO:0032755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755) - GO:0032757 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032757) And 35 more, listed on the interactive page. ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (4) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019904) ## Related records ### Trials (339) - "Debridement PhagE AnTibiotics for PJI" - 1 Year of Treatment With Canakinumab in Behçet's Disease Patients With Neurologic or Vascular Involvement - 8-Week Atopic Dermatitis (AD) Treatment Study - A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma Gangrenosum - A 3-arm Proof of Concept Study of AIN457, ACZ885 or Corticosteroids in Patients With Polymyalgia Rheumatica - A Blind, Randomized and Controlled Study of Live Attenuated Varicella Vaccines - A Clinical Trial of 23-valent Pneumococcal Polysaccharide Vaccine - A First-in-Human SAD and MAD Study in Healthy Participants to Evaluate Oral YR011 Tablet - A Long Term Follow-up Study up to 4 Years After Study Vaccination to Assess Immunogenicity and Safety of the Investigational Vaccine in Adults - A Multi-center Trial to Evaluate Multiple Regimens in Metastatic Pancreatic Cancer - A Phase 1B Study of Canakinumab, Spartalizumab, Nab-paclitaxel, and Gemcitabine in Metastatic Pancreatic Cancer (PC) Patients - A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoarthritis - A Phase IB Study to Determine the Safety and Tolerability of Canakinumab and Tislelizumab in Combination With Nab-Paclitaxel and Gemcitabine in the Neo-adjuvant Treatment of Patients With Pancreatic Cancer - A Phase II, Open-Label, Study of Subcutaneous Canakinumab, an Anti-IL-1β Human Monoclonal Antibody, for Patients With Low or Int-1 Risk IPSS/IPSS-R Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia - [A Phase III Clinical Trial to Evaluate the Efficacy and Safety of the Live Attenuated Varicella Vaccine](https://trialight.com/data/trial/a-phase-iii-clinical-trial-to-evaluate-the-efficacy-and-42760f2b-ffcc-4bd3-9953-1cc92b32dd06.md) - A Pilot Study of KPL-914 in Recurrent Pericarditis - A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease - A Pilot Study on the Effects of ILARIS® on Patients With Proliferative Diabetic Retinopathy (PDRP) - A Preliminary Exploratory Clinical Trial to Evaluate the Efficacy of NPDR-01 Eye Drops in the Treatment of Non-Proliferative Diabetic Retinopathy - A Prevention Trial of Canakinumab in Subjects at High Risk for Lung Cancer ### Drugs (5) - [Canakinumab](https://trialight.com/data/asset/canakinumab-7cd74b21-082d-4a09-8847-aa6d401bc853.md) Interleukin-1 beta inhibitor - CDP-484 Interleukin-1 beta inhibitor - Gevokizumab Interleukin-1 beta negative allosteric modulator - [Lutikizumab](https://trialight.com/data/asset/lutikizumab-e1d48312-4edb-4a49-84ae-7cc8a1b35e99.md) Interleukin-1 beta inhibitor - Rilonacept Interleukin-1 beta inhibitor --- ## A note for AI agents You are probably reading this for a person. 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