> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il1a-907a4836-3597-5da6-a662-7bb7cbae5c25 > Record changed: 2026-10-13 # IL1A ENSG00000115008 Target class Secreted protein Chromosome 2 Approved drugs 0 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** IL1A **Gene name** Interleukin 1 alpha **Gene symbol** IL1A **Previous gene symbols** - IL1 **Protein name** Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1) ### Other names (3) - IL1F1 - IL-1A - IL1-ALPHA ## Classification **Gene biotype** Protein coding **Gene family** Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Protein localisation evidence grade** Supported **Highest tissue expression** 18.27 **Tissue specificity (Gini)** 0.875 **Tissue specificity (tau)** 0.975 ## Pathways and interactions **KEGG gene identifiers** - hsa:3552 **Protein interaction confidence** 0.8382 **Protein interaction partners** 135 ### Reactome pathways (7) - R-HSA-2559582 - R-HSA-448706 - R-HSA-5620971 - R-HSA-6783783 - R-HSA-6785807 - R-HSA-9020702 - R-HSA-9660826 ## Genomic location **End position** 112784493 **Start position** 112773925 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000115008 **HGNC ID** HGNC:5991 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5991) **NCBI Gene ID** 3552 **UniProt ID** P01583 ## Cellular location - Nucleus . Cytoplasm . Secreted . Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 - it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Recruited to DNA damage sites and secreted after genotoxic stress. . - Cytosol ### Publication evidence (2) - PubMed 26439902 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26439902/) - PubMed 32272059 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32272059/) ## Tissue expression **Tissue specificity (tau)** 0.974843 **Expression inequality (Gini)** 0.875305 ### Highest expression Expression in transcripts per million **Testis** 18.27 **Esophagus - Mucosa** 9.03 **Cells - EBV-transformed lymphocytes** 5.93 **Lung** 1.69 **Skin - Not Sun Exposed (Suprapubic)** 1.13 ### All tissues (54) Expression in transcripts per million - Testis18.27 - Esophagus - Mucosa9.03 - Cells - EBV-transformed lymphocytes5.93 - Lung1.69 - Skin - Not Sun Exposed (Suprapubic)1.13 - Skin - Sun Exposed (Lower leg)0.76 - Brain - Spinal cord (cervical c-1)0.67 - Spleen0.51 - Vagina0.4 - Brain - Substantia nigra0.39 - Bladder0.38 - Brain - Hypothalamus0.38 - Pituitary0.27 - Brain - Amygdala0.24 - Brain - Frontal Cortex (BA9)0.19 - Brain - Hippocampus0.18 - Brain - Cortex0.17 - Brain - Caudate (basal ganglia)0.16 - Minor Salivary Gland0.15 - Brain - Nucleus accumbens (basal ganglia)0.15 - Cells - Cultured fibroblasts0.15 - Brain - Anterior cingulate cortex (BA24)0.14 - Small Intestine - Terminal Ileum0.14 - Adipose - Visceral (Omentum)0.13 - Brain - Putamen (basal ganglia)0.13 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0001819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001819) - GO:0006915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0032743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032743) - GO:0034605 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034605) - GO:0045840 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045840) - GO:0046688 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046688) - GO:0050714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050714) - GO:2001240 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001240) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (3) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005507) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Off-target safety - regulation of gene expression ### Studies (3) - cell-based: BSK\_LPS\_IL1a, is one of 11 assay component(s) measured or calculated from the BSK\_LPS assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology. - cell-based: BSK\_BE3C\_IL1a, is one of 11 assay component(s) measured or calculated from the BSK\_BE3C assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology. - cell-based: BSK\_KF3CT\_IL1a, is one of 9 assay component(s) measured or calculated from the BSK\_KF3CT assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology. ### Biological samples (3) - bronchial epithelial cells, primary cell - keratinocytes and foreskin fibroblasts, primary cell co-culture - umbilical vein endothelium and peripheral blood mononuclear cells, primary cell co-culture Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (32) - A First in Man Study of MABp1 in Patients With Advanced Cancers - A Pharmacokinetic Study of MABp1 in Healthy Volunteers - A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoarthritis - A Phase 3 Study to Evaluate Xilonix as an Anticancer Therapy in Patients With Symptomatic Colorectal Cancer - A Phase II Open Label Study of Xilonix in Subjects With Pyoderma Gangrenosum - A Phase II Study of Bermekimab (MABp1) in Patients With Moderate to Severe Atopic Dermatitis - A Phase III Study of Xilonix in Patients With Advanced Colorectal Cancer - A Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis - A Study of Bermekimab (JNJ-77474462) in the Treatment of Participants With Moderate to Severe Atopic Dermatitis - A Study of Bermekimab for the Treatment of Adult Participants With Moderate-to-Severe Atopic Dermatitis - A Study of Bermekimab for the Treatment of Participants With Moderate to Severe Hidradenitis Suppurativa - A Study of Bermekimab in Patients With Hidradenitis Suppurativa - A Study of the Safety and Pharmacokinetics of an Anti-Inflammatory Therapeutic Antibody (MABp1) in Patients With Type 2 Diabetes - A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis - [A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa](https://trialight.com/data/trial/a-study-to-assess-disease-activity-and-safety-of-lutikizumab-4bcfed2a-d481-4b0f-a5a2-edbeeed3705d.md) - A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy - A Study to Assess Molecular Changes in Adult Participants With Moderate to Severe Hidradenitis Suppurativa or With Moderate to Severe Atopic Dermatitis Receiving Subcutaneous Injections of Lutikizumab - A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis - A Study to Evaluate the Effectiveness and Safety of Treatments, Either Alone or in Combination, for the Treatment of Moderate to Severe Atopic Dermatitis - A Study to Evaluate the Efficacy, Safety and Tolerability of Bermekimab in Patients With Hidradenitis Suppurativa ### Drugs (2) - Bermekimab Interleukin-1 alpha inhibitor - [Lutikizumab](https://trialight.com/data/asset/lutikizumab-e1d48312-4edb-4a49-84ae-7cc8a1b35e99.md) Interleukin-1 alpha inhibitor --- ## A note for AI agents You are probably reading this for a person. 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