IL1A

ENSG00000115008
Target class
Secreted protein
Chromosome
2
Approved drugs
0
Clinical candidates (approved and in development)
2

Approved drugs
0
Clinical candidates (approved and in development)
2

Chemical probe available
No

Target name
IL1A
Gene name
Interleukin 1 alpha
Gene symbol
IL1A
Previous gene symbols
  • IL1
Protein name
Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)

  • IL1F1
  • IL-1A
  • IL1-ALPHA

Gene biotype
Protein coding
Gene family
Interleukins
Target class
Secreted protein
Target type
Human gene

Tissues expressed in
5
Protein localisation evidence grade
Supported
Highest tissue expression
18.27
Tissue specificity (Gini)
0.875
Tissue specificity (tau)
0.975

KEGG gene identifiers
  • hsa:3552
Protein interaction confidence
0.8382
Protein interaction partners
135

  • R-HSA-2559582
  • R-HSA-448706
  • R-HSA-5620971
  • R-HSA-6783783
  • R-HSA-6785807
  • R-HSA-9020702
  • R-HSA-9660826

End position
112784493
Start position
112773925
Chromosome
2
Strand
Reverse

Ensembl gene ID
ENSG00000115008
HGNC ID
HGNC:5991
www.genenames.org
NCBI Gene ID
3552
UniProt ID
P01583

  • Nucleus . Cytoplasm . Secreted . Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10
  • it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Recruited to DNA damage sites and secreted after genotoxic stress. .
  • Cytosol

Tissue specificity (tau)
0.974843
Expression inequality (Gini)
0.875305

Expression in transcripts per million

Testis
18.27
Esophagus - Mucosa
9.03
Cells - EBV-transformed lymphocytes
5.93
Lung
1.69
Skin - Not Sun Exposed (Suprapubic)
1.13

Expression in transcripts per million

  • Testis18.27
  • Esophagus - Mucosa9.03
  • Cells - EBV-transformed lymphocytes5.93
  • Lung1.69
  • Skin - Not Sun Exposed (Suprapubic)1.13
  • Skin - Sun Exposed (Lower leg)0.76
  • Brain - Spinal cord (cervical c-1)0.67
  • Spleen0.51
  • Vagina0.4
  • Brain - Substantia nigra0.39
  • Bladder0.38
  • Brain - Hypothalamus0.38
  • Pituitary0.27
  • Brain - Amygdala0.24
  • Brain - Frontal Cortex (BA9)0.19
  • Brain - Hippocampus0.18
  • Brain - Cortex0.17
  • Brain - Caudate (basal ganglia)0.16
  • Minor Salivary Gland0.15
  • Brain - Nucleus accumbens (basal ganglia)0.15
  • Cells - Cultured fibroblasts0.15
  • Brain - Anterior cingulate cortex (BA24)0.14
  • Small Intestine - Terminal Ileum0.14
  • Adipose - Visceral (Omentum)0.13
  • Brain - Putamen (basal ganglia)0.13

And 29 more, listed on the interactive page.

  • regulation of gene expression

    • cell-based: BSK_LPS_IL1a, is one of 11 assay component(s) measured or calculated from the BSK_LPS assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology.
    • cell-based: BSK_BE3C_IL1a, is one of 11 assay component(s) measured or calculated from the BSK_BE3C assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology.
    • cell-based: BSK_KF3CT_IL1a, is one of 9 assay component(s) measured or calculated from the BSK_KF3CT assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology.

    • bronchial epithelial cells, primary cell
    • keratinocytes and foreskin fibroblasts, primary cell co-culture
    • umbilical vein endothelium and peripheral blood mononuclear cells, primary cell co-culture
    Evidence source
    www.epa.gov

Related records

Trials (32)

Drugs (2)