> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/il18-6856427e-0233-5cbe-ade1-0c708535a973
> Record changed: 2026-10-13

# IL18

ENSG00000150782

Target class

Secreted protein

Chromosome

11

Approved drugs

0

Clinical candidates (approved and in development)

3

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

3

## Druggability

**Chemical probe available**

No

## Names

**Target name**

IL18

**Gene name**

Interleukin 18

**Gene symbol**

IL18

**Protein name**

Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)

### Other names (4)

- IGIF
- IL1F4
- IL-1g
- IL-18

## Classification

**Gene biotype**

Protein coding

**Gene family**

Interleukins

**Target class**

Secreted protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

51

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

169.06

**Tissue specificity (Gini)**

0.694

**Tissue specificity (tau)**

0.897

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3606

**Protein interaction confidence**

0.843928

**Protein interaction partners**

83

### Reactome pathways (8)

- R-HSA-448706
- R-HSA-5620971
- R-HSA-6783783
- R-HSA-6785807
- R-HSA-9012546
- R-HSA-9660826
- R-HSA-9960519
- R-HSA-9960525

## Genomic location

**End position**

112164106

**Start position**

112143251

**Chromosome**

11

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000150782

**HGNC ID**

HGNC:5986

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5986)

**NCBI Gene ID**

3606

**UniProt ID**

Q14116

## Cellular location

- Cytoplasm, cytosol . Secreted . Note=The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744, PubMed:37993712, PubMed:37993714). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744, PubMed:37993714). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1, CASP4 or CASP5 during maturation (PubMed:33883744, PubMed:37993714). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
- Cytosol
- Golgi apparatus

### Publication evidence (6)

- PubMed 32272059  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32272059/)
- PubMed 33883744  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33883744/)
- PubMed 9334240  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9334240/)
- PubMed 23955712  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23955712/)
- PubMed 37993712  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37993712/)
- PubMed 37993714  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37993714/)

## Tissue expression

**Tissue specificity (tau)**

0.896735

**Expression inequality (Gini)**

0.693568

### Highest expression

Expression in transcripts per million

**Skin - Sun Exposed (Lower leg)**

169.06

**Skin - Not Sun Exposed (Suprapubic)**

164.8

**Esophagus - Mucosa**

132.08

**Vagina**

113.83

**Spleen**

58

### All tissues (54)

Expression in transcripts per million

- Skin - Sun Exposed (Lower leg)169.06
- Skin - Not Sun Exposed (Suprapubic)164.8
- Esophagus - Mucosa132.08
- Vagina113.83
- Spleen58
- Nerve - Tibial39.31
- Lung36.26
- Small Intestine - Terminal Ileum32.02
- Adipose - Visceral (Omentum)30.46
- Colon - Transverse30.01
- Kidney - Cortex27.54
- Kidney - Medulla22.46
- Bladder18.61
- Brain - Spinal cord (cervical c-1)15.8
- Prostate13.27
- Minor Salivary Gland12.05
- Adipose - Subcutaneous9.82
- Whole Blood9.79
- Artery - Coronary8.94
- Fallopian Tube8.49
- Esophagus - Gastroesophageal Junction8.46
- Stomach8.27
- Artery - Aorta8.2
- Esophagus - Muscularis7.35
- Adrenal Gland7.11

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (22)

- GO:0001525  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525)
- GO:0007267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267)
- GO:0030155  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030155)
- GO:0032722  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722)
- GO:0032725  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032725)
- GO:0032729  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729)
- GO:0032736  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032736)
- GO:0032740  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032740)
- GO:0032819  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032819)
- GO:0034105  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034105)
- GO:0035655  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035655)
- GO:0042088  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042088)
- GO:0042092  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042092)
- GO:0042104  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042104)
- GO:0042531  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042531)
- GO:0045944  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)
- GO:0048661  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048661)
- GO:0050729  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729)
- GO:0051142  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051142)
- GO:0051897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897)
- GO:0150078  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150078)
- GO:2000556  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000556)

### Cellular components (2)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)

### Molecular functions (3)

- GO:0005125  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0045515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045515)

## Related records

### Trials (9)

- [A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis](https://trialight.com/data/trial/a-phase-2b-study-of-the-effects-of-camoteskimab-in-adults-79c26739-27cf-4aa9-8fdd-fb99ce4b9b09.md)
- A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis
- A Study to Evaluate Camoteskimab in Participants With Still's Disease
- A Study to Evaluate the Safety of MEDI2338 in Subjects With Chronic Obstructive Pulmonary Disease
- Phase 1b Study of AEVI-007 in Subjects With Relapsed or Refractory Multiple Myeloma
- Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome
- Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease
- Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency
- Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency As Open Label Extension

### Drugs (3)

- [Camoteskimab](https://trialight.com/data/asset/camoteskimab-48927821-d0ff-4f39-82a9-4d5e630d220c.md) Interleukin-18 cross-linking agent
- GSK-1070806 Interleukin-18 inhibitor
- Tadekinig alfa Interleukin-18 inhibitor

---

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