> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il17f-c9ab0f20-5ebd-5ddc-babc-19463f622d21 > Record changed: 2026-10-13 # IL17F ENSG00000112116 Target class Secreted protein Chromosome 6 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** IL17F **Gene name** Interleukin 17F **Gene symbol** IL17F **Protein name** Interleukin-17F (IL-17F) (Cytokine ML-1) ### Other names (3) - IL-17F - ML-1 - ML1 ## Classification **Gene biotype** Protein coding **Gene family** Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 1.19 **Tissue specificity (Gini)** 0.977 **Tissue specificity (tau)** 0.998 ## Pathways and interactions **KEGG gene identifiers** - hsa:112744 **Protein interaction confidence** 0.846743 **Protein interaction partners** 35 ### Reactome pathways (3) - R-HSA-448424 - R-HSA-6785807 - R-HSA-9705671 ## Genomic location **End position** 52245689 **Start position** 52236681 **Chromosome** 6 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000112116 **HGNC ID** HGNC:16404 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:16404) **NCBI Gene ID** 112744 **UniProt ID** Q96PD4 ## Cellular location - Secreted . ## Tissue expression **Tissue specificity (tau)** 0.998097 **Expression inequality (Gini)** 0.977241 ### Highest expression Expression in transcripts per million **Testis** 1.19 **Brain - Cerebellum** 0.09 **Brain - Nucleus accumbens (basal ganglia)** 0.03 **Brain - Hypothalamus** 0 **Cells - EBV-transformed lymphocytes** 0 ### All tissues (54) Expression in transcripts per million - Testis1.19 - Brain - Cerebellum0.09 - Brain - Nucleus accumbens (basal ganglia)0.03 - Brain - Hypothalamus0 - Cells - EBV-transformed lymphocytes0 - Artery - Coronary0 - Spleen0 - Liver0 - Minor Salivary Gland0 - Fallopian Tube0 - Heart - Atrial Appendage0 - Cervix - Endocervix0 - Kidney - Medulla0 - Adipose - Subcutaneous0 - Brain - Cortex0 - Brain - Amygdala0 - Esophagus - Muscularis0 - Brain - Frontal Cortex (BA9)0 - Heart - Left Ventricle0 - Kidney - Cortex0 - Skin - Not Sun Exposed (Suprapubic)0 - Esophagus - Mucosa0 - Breast - Mammary Tissue0 - Bladder0 - Artery - Tibial0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0001819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001819) - GO:0016525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016525) - GO:0017015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017015) - GO:0032645 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032645) - GO:0032663 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032663) - GO:0032675 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032675) - GO:0032677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032677) - GO:0032755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755) - GO:0032761 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032761) - GO:0051216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051216) - GO:0097400 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097400) - GO:2000340 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000340) ### Cellular components - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) ### Molecular functions (4) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019955) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) ## Related records ### Trials (66) - A Bioequivalence Study of Bimekizumab Given as 1x2mL or 2x1mL Subcutaneous Injection Using an Autoinjector in Healthy Study Participants - A Phase 2b Study of the Efficacy, Safety, and Tolerability of M1095 (Sonelokimab) in Subjects With Moderate to Severe Psoriasis - A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (The SKYLIGHT Trial) - A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab) - A Study to Assess the Long-term Safety, Tolerability, and Efficacy of Bimekizumab in the Treatment of Subjects With Active Psoriatic Arthritis - A Study to Assess the Pharmacokinetics and Safety of Bimekizumab in Children and Adolescents With Moderate to Severe Hidradenitis Suppurativa - A Study to Assess the Pharmacokinetics, Safety, and Efficacy of Two Doses of Bimekizumab in Adolescent Study Participants With Moderate to Severe Plaque Psoriasis - A Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of UCB4940 in Patients With Psoriasis - A Study to Compare the Blood Level of Bimekizumab Injected Subcutaneously Either by a Prefilled Syringe or by an Auto-injector in Adult Healthy Volunteer Participants - A Study to Evaluate the Antibody Response of Influenza Vaccination Following Concomitant Exposure to Bimekizumab in Healthy Subjects - A Study to Evaluate the Bioequivalence of Bimekizumab Given as 1x2mL or 2x1mL Subcutaneous Injection in Healthy Study Participants - A Study to Evaluate the Dose Response Based on the Efficacy, Safety and Tolerability of Bimekizumab in Subjects With Active Psoriatic Arthritis Which is a Type of Inflammatory Arthritis - A Study to Evaluate the Effect of Bimekizumab on Gene Expression Biomarkers in Study Participants With Moderate to Severe Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to an Active Comparator in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Placebo and an Active Comparator in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Korean Study Participants With Moderate to Severe Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Study Participants With Active Psoriatic Arthritis - A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis - A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis ### Drugs (2) - [Bimekizumab](https://trialight.com/data/asset/bimekizumab-74957cc7-f3d4-4173-babe-0de5e90fd2dd.md) Interleukin-17F inhibitor - [M-1095](https://trialight.com/data/asset/m-1095-714be268-151a-4095-b560-76430e46c3dd.md) Interleukin-17F inhibitor --- ## A note for AI agents You are probably reading this for a person. 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