> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il17a-268aa9f8-47ae-5ed5-b2b2-9e59867ebb93 > Record changed: 2026-10-13 # IL17A ENSG00000112115 Target class Secreted protein Chromosome 6 Approved drugs 3 Clinical candidates (approved and in development) 11 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 11 ## Druggability **Chemical probe available** No ## Names **Target name** IL17A **Gene name** Interleukin 17A **Gene symbol** IL17A **Protein name** Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8) ### Other names (2) - IL-17A - IL-17 ### Previous gene symbols (2) - CTLA8 - IL17 ## Classification **Gene biotype** Protein coding **Gene family** Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Highest tissue expression** 0.03 **Tissue specificity (Gini)** 0.981 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:3605 **Protein interaction confidence** 0.827417 **Protein interaction partners** 115 ### Reactome pathways (3) - R-HSA-448424 - R-HSA-6785807 - R-HSA-9705671 ## Genomic location **End position** 52190638 **Start position** 52186375 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000112115 **HGNC ID** HGNC:5981 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5981) **NCBI Gene ID** 3605 **UniProt ID** Q16552 ## Cellular location - Secreted . ### Publication evidence (2) - PubMed 17763419 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17763419/) - PubMed 8676080 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8676080/) ## Tissue expression **Tissue specificity (tau)** 1 **Expression inequality (Gini)** 0.981481 ### Highest expression Expression in transcripts per million **Small Intestine - Terminal Ileum** 0.03 **Thyroid** 0 **Artery - Coronary** 0 **Minor Salivary Gland** 0 **Prostate** 0 ### All tissues (54) Expression in transcripts per million - Small Intestine - Terminal Ileum0.03 - Thyroid0 - Artery - Coronary0 - Minor Salivary Gland0 - Prostate0 - Bladder0 - Brain - Anterior cingulate cortex (BA24)0 - Pancreas0 - Brain - Cortex0 - Muscle - Skeletal0 - Kidney - Cortex0 - Artery - Tibial0 - Ovary0 - Esophagus - Muscularis0 - Testis0 - Breast - Mammary Tissue0 - Brain - Nucleus accumbens (basal ganglia)0 - Heart - Left Ventricle0 - Heart - Atrial Appendage0 - Brain - Cerebellar Hemisphere0 - Kidney - Medulla0 - Esophagus - Gastroesophageal Junction0 - Skin - Not Sun Exposed (Suprapubic)0 - Cells - Cultured fibroblasts0 - Colon - Transverse0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (18) - GO:0006915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0008219 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008219) - GO:0009611 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009611) - GO:0032731 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032731) - GO:0032735 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032735) - GO:0032739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032739) - GO:0032747 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032747) - GO:0032755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755) - GO:0032760 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032760) - GO:0038173 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038173) - GO:0045672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045672) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0072537 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072537) - GO:0097400 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097400) - GO:1900017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900017) - GO:2000340 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000340) ### Cellular components - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) ### Molecular functions (2) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (496) - "Pharmacoepidemiological Evaluation of Autophagy Inhibition in Treatment of HCV Patients Resistant to Standard Therapy. Pilot Study" - 16 Week Efficacy and 2 Year Long Term Safety and Efficacy of Secukinumab in Patients With Active Ankylosing Spondylitis - 16 Week Efficacy and 5 Year Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Ankylosing Spondylitis - 16-week Efficacy and 2-year Safety, Tolerability and Efficacy of Secukinumab in Participants With Active Ankylosing Spondylitis - 16-week Efficacy and 2-year Safety, Tolerability and Efficacy of Secukinumab in Participants With Active Psoriatic Arthritis - 16-week Efficacy and 3-year Safety, Tolerability and Efficacy of Secukinumab in Active Ankylosing Spondylitis Patients - 24 Week Efficacy and 3-year Safety and Efficacy of Secukinumab in Active Psoriatic Arthritis - 38 Week Extension Study to CAIN457C2303 - 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain - 4 Year Extension Study of Efficacy and Safety of Secukinumab in Patients With Moderate to Severe Chronic Plaque-type Psoriasis - A 24-week, Multicenter, proSpective stUdy to Evaluate the PASI 90 Clinical Response Rate and the Safety PRofile of sEcukinuMab 300 mg in Cw6-negativE and Cw6-positive Patients With Moderate to Severe Chronic Plaque-type Psoriasis (SUPREME) - A 3-arm Proof of Concept Study of AIN457, ACZ885 or Corticosteroids in Patients With Polymyalgia Rheumatica - A Bioequivalence Study of Bimekizumab Given as 1x2mL or 2x1mL Subcutaneous Injection Using an Autoinjector in Healthy Study Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study to Compare Two Formulations of SHR-1314 After Subcutaneous Injection in Healthy Subjects - A Biomarker Study of Secukinumab in Rheumatoid Arthritis (RA) Patients - A Clinical Study to Compare the Safety and Pharmacokinetics of SHR-1314 Injection in Healthy Subjects at Different Specifications Devices - A Clinical Study to Investigate the Effect of an Investigational Drug on Electrocardiogram Intervals in Adults With Schizophrenia. - A Comparative Pharmacokinetic Study of ORTHO EVRA (a Transdermal Contraceptive Patch) and CILEST (an Oral Contraceptive) in Healthy Female Volunteers ### Drugs (11) - Afasevikumab Interleukin 17A inhibitor - [Bimekizumab](https://trialight.com/data/asset/bimekizumab-74957cc7-f3d4-4173-babe-0de5e90fd2dd.md) Interleukin 17A inhibitor - CJM-112 Interleukin 17A binding agent - [Ixekizumab](https://trialight.com/data/asset/ixekizumab-e6c0361f-63a0-4185-9dba-866e282f24be.md) Interleukin 17A inhibitor - Izokibep Interleukin 17A inhibitor - [M-1095](https://trialight.com/data/asset/m-1095-714be268-151a-4095-b560-76430e46c3dd.md) Interleukin 17A inhibitor - Perakizumab Interleukin 17A inhibitor - Remtolumab Interleukin 17A inhibitor - [Secukinumab](https://trialight.com/data/asset/secukinumab-6a7cb482-c244-4544-b6c6-4d8b9bb415bf.md) Interleukin 17A inhibitor - Tibulizumab Interleukin 17A inhibitor - Vunakizumab Interleukin 17A inhibitor --- ## A note for AI agents You are probably reading this for a person. 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