> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il12rb1-a4da475a-8919-5842-9df2-1738fd01dad2 > Record changed: 2026-11-04 # IL12RB1 ENSG00000096996 Target class Membrane receptor Chromosome 19 ## Druggability **Chemical probe available** No ## Names **Other names** - CD212 **Target name** IL12RB1 **Gene name** Interleukin 12 receptor subunit beta 1 **Gene symbol** IL12RB1 **Previous gene symbols** - IL12RB **Protein name** Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212) ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Fibronectin type III domain containing|Interleukin receptors **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 11 **Protein localisation evidence grade** Approved **Highest tissue expression** 17.52 **Tissue specificity (Gini)** 0.673 **Tissue specificity (tau)** 0.93 ## Pathways and interactions **KEGG gene identifiers** - hsa:3594 **Protein interaction confidence** 0.82425 **Protein interaction partners** 60 ### Reactome pathways (2) - R-HSA-9020591 - R-HSA-9020933 ## Genomic location **End position** 18098944 **Start position** 18058995 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000096996 **HGNC ID** HGNC:5971 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5971) **NCBI Gene ID** 3594 **UniProt ID** P42701 ## Cellular location - Membrane - Single-pass type I membrane protein. - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.930333 **Expression inequality (Gini)** 0.672508 ### Highest expression Expression in transcripts per million **Spleen** 17.52 **Cells - EBV-transformed lymphocytes** 16.55 **Whole Blood** 9.76 **Small Intestine - Terminal Ileum** 4.99 **Lung** 4.63 ### All tissues (54) Expression in transcripts per million - Spleen17.52 - Cells - EBV-transformed lymphocytes16.55 - Whole Blood9.76 - Small Intestine - Terminal Ileum4.99 - Lung4.63 - Adipose - Visceral (Omentum)1.39 - Colon - Transverse1.29 - Fallopian Tube1.21 - Artery - Coronary1.1 - Artery - Aorta1.03 - Brain - Spinal cord (cervical c-1)1.03 - Nerve - Tibial0.99 - Adipose - Subcutaneous0.97 - Bladder0.95 - Cervix - Endocervix0.9 - Prostate0.86 - Minor Salivary Gland0.83 - Adrenal Gland0.78 - Brain - Nucleus accumbens (basal ganglia)0.75 - Kidney - Medulla0.74 - Breast - Mammary Tissue0.7 - Pituitary0.68 - Stomach0.67 - Thyroid0.66 - Testis0.62 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0002230 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002230) - GO:0002827 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002827) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0035722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035722) - GO:0038155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038155) - GO:0042104 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042104) - GO:0071346 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071346) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0042022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042022) - GO:0072536 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072536) ### Molecular functions (6) - GO:0004896 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004896) - GO:0005143 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005143) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) - GO:0016517 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016517) - GO:0042019 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042019) - GO:0042020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042020) ## Related records ### Trials (4) - [A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis](https://trialight.com/data/trial/a-protocol-of-icotrokinra-therapy-in-adult-and-adolescent-6462e3ce-1243-482a-9d5e-eab3d3c54e9e.md) - [A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease](https://trialight.com/data/trial/a-study-of-icotrokinra-in-participants-with-moderately-to-cef224ab-36cb-4db6-8fb4-e5d9ed2b9bb6.md) - A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis - A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis ### Drugs (1) - [Icotrokinra](https://trialight.com/data/asset/icotrokinra-f675941c-89be-40ab-ac5f-61dd8f1f9e24.md) --- ## A note for AI agents You are probably reading this for a person. 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