> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il12b-92e53178-7b56-555c-ac6b-a1235d8fe7e5 > Record changed: 2026-10-13 # IL12B ENSG00000113302 Target class Secreted protein Chromosome 5 Approved drugs 5 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Target name** IL12B **Gene name** Interleukin 12B **Gene symbol** IL12B **Previous gene symbols** - NKSF2 **Protein name** Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2) ### Other names (4) - CLMF - IL-12B - NKSF - CLMF2 ## Classification **Gene biotype** Protein coding **Gene family** Immunoglobulin like domain containing|Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 1 **Tissue specificity (Gini)** 0.859 **Tissue specificity (tau)** 0.964 ## Pathways and interactions **KEGG gene identifiers** - hsa:3593 **Protein interaction confidence** 0.803619 **Protein interaction partners** 21 ### Reactome pathways (4) - R-HSA-6783783 - R-HSA-6785807 - R-HSA-9020591 - R-HSA-9020933 ## Genomic location **End position** 159330863 **Start position** 159314780 **Chromosome** 5 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000113302 **HGNC ID** HGNC:5970 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5970) **NCBI Gene ID** 3593 **UniProt ID** P29460 ## Cellular location - Secreted. ## Tissue expression **Tissue specificity (tau)** 0.963585 **Expression inequality (Gini)** 0.858994 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 1 **Pituitary** 0.77 **Testis** 0.14 **Kidney - Cortex** 0.14 **Minor Salivary Gland** 0.14 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes1 - Pituitary0.77 - Testis0.14 - Kidney - Cortex0.14 - Minor Salivary Gland0.14 - Lung0.12 - Spleen0.1 - Kidney - Medulla0.08 - Brain - Cerebellum0.07 - Brain - Cerebellar Hemisphere0.06 - Thyroid0.04 - Cervix - Endocervix0.04 - Small Intestine - Terminal Ileum0.04 - Cells - Cultured fibroblasts0.02 - Brain - Nucleus accumbens (basal ganglia)0.02 - Brain - Hypothalamus0.02 - Skin - Sun Exposed (Lower leg)0.02 - Esophagus - Mucosa0.02 - Whole Blood0.01 - Skin - Not Sun Exposed (Suprapubic)0.01 - Brain - Putamen (basal ganglia)0.01 - Brain - Caudate (basal ganglia)0.01 - Brain - Frontal Cortex (BA9)0.01 - Brain - Substantia nigra0.01 - Brain - Anterior cingulate cortex (BA24)0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (40) - GO:0001817 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001817) - GO:0002230 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002230) - GO:0002827 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002827) - GO:0002860 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002860) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0010224 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010224) - GO:0016477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477) - GO:0030101 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030101) - GO:0032693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032693) - GO:0032700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032700) - GO:0032725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032725) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032733 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032733) - GO:0032735 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032735) - GO:0032740 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032740) - GO:0032760 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032760) - GO:0032816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032816) - GO:0032819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032819) - GO:0032946 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032946) - GO:0034105 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034105) - GO:0034393 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034393) - GO:0035722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035722) - GO:0038155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038155) - GO:0042088 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042088) - GO:0042093 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042093) And 15 more, listed on the interactive page. ### Cellular components (6) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0031906 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031906) - GO:0043514 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043514) - GO:0070743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070743) ### Molecular functions (8) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005143 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005143) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083) - GO:0042164 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042164) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0045519 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045519) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) ## Related records ### Trials (501) - [A Bioequivalence Study of Mirikizumab (LY3074828) in Healthy Participants](https://trialight.com/data/trial/a-bioequivalence-study-of-mirikizumab-ly3074828-in-healthy-66c85922-0858-4fa5-a0f5-958e525f0e08.md) - [A Bioequivalence Study of Mirikizumab (LY3074828) Solution in Healthy Participants](https://trialight.com/data/trial/a-bioequivalence-study-of-mirikizumab-ly3074828-solution-in-f9d1d4b3-5de5-44e2-b8cc-5b4322e4c740.md) - A Clinical Study of AK101 in Subjects With Moderate to Severe Plaque Psoriasis - A Direct Head-to-head Comparison of Ustekinumab with Infliximab for the Treatment of Ulcerative Colitis - A Double-blind Study to Compare the Efficacy, Safety, and Immunogenicity of the Proposed Biosimilar Ustekinumab FYB202 to Stelara® in Patients With Moderate-to-Severe Plaque Psoriasis - A Global Study Comparing Risankizumab to Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa - A Long Term Extension Trial of BI 655066/ABBV-066 (Risankizumab), in Patients With Moderately to Severely Active Crohn's Disease - A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants - A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease - A Long-term Extension Study of Ustekinumab in Pediatric Participants - A Long-term Study to Evaluate Safety and Maintenance of Treatment Effect of LY3074828 in Participants With Moderate-to-Severe Plaque Psoriasis (OASIS-3) - A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis - A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON) - A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU) - A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Ulcerative Colitis - A Multicentered Prospective Cohort Study of Chinese IBD Patients - A Pharmacokinetic Study Comparing EG12014 and Herceptin (Trastuzumab) in Healthy Male Volunteers - A Pharmacokinetic Study of Single-Dose Intravenous Ustekinumab Delivered in 2 Different Liquid in Vial Formulations - A Pharmacokinetic Study of Ustekinumab in Pediatric Subjects With Moderately to Severely Active Crohn's Disease - A Phase 2a, Efficacy and Safety Study of Ustekinumab in Systemic Lupus Erythematosus ### Drugs (8) - Brazikumab Interleukin-23 inhibitor - Briakinumab Interleukin-23 inhibitor - Ebdarokimab Interleukin-12 inhibitor - [Guselkumab](https://trialight.com/data/asset/guselkumab-90846a1b-25ed-4e53-ae9c-4730391bc3c9.md) Interleukin-23 inhibitor - [Mirikizumab](https://trialight.com/data/asset/mirikizumab-125dbf98-9c8f-4161-a506-f2b426cbee0c.md) Interleukin-23 inhibitor - [Risankizumab](https://trialight.com/data/asset/risankizumab-1241776f-1eaf-44f0-80a5-991f76bf1ea0.md) Interleukin-23 inhibitor - Tildrakizumab Interleukin-23 inhibitor - [Ustekinumab](https://trialight.com/data/asset/ustekinumab-323cb2e2-e906-4997-ac57-d82c7f7c399d.md) Interleukin-12 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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