> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/il12a-f7e63dfd-cd53-5ed7-ab6b-30bc302a7278 > Record changed: 2026-10-13 # IL12A ENSG00000168811 Target class Secreted protein Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** IL12A **Gene name** Interleukin 12A **Gene symbol** IL12A **Previous gene symbols** - NKSF1 **Protein name** Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1) ### Other names (4) - CLMF - IL-12A - p35 - NFSK ## Classification **Gene biotype** Protein coding **Gene family** Interleukins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 23 **Highest tissue expression** 7.36 **Tissue specificity (Gini)** 0.482 **Tissue specificity (tau)** 0.859 ## Pathways and interactions **KEGG gene identifiers** - hsa:3592 **Protein interaction confidence** 0.791059 **Protein interaction partners** 17 ### Reactome pathways (4) - R-HSA-6783783 - R-HSA-6785807 - R-HSA-8984722 - R-HSA-9020591 ## Genomic location **End position** 159996019 **Start position** 159988835 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000168811 **HGNC ID** HGNC:5969 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5969) **NCBI Gene ID** 3592 **UniProt ID** P29459 ## Cellular location - Secreted . ### Publication evidence (2) - PubMed 1674604 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1674604/) - PubMed 9342359 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9342359/) ## Tissue expression **Tissue specificity (tau)** 0.858926 **Expression inequality (Gini)** 0.481781 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 7.36 **Esophagus - Mucosa** 6.58 **Spleen** 3.48 **Lung** 2.93 **Cells - Cultured fibroblasts** 2.9 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes7.36 - Esophagus - Mucosa6.58 - Spleen3.48 - Lung2.93 - Cells - Cultured fibroblasts2.9 - Small Intestine - Terminal Ileum1.91 - Brain - Substantia nigra1.73 - Colon - Sigmoid1.61 - Brain - Amygdala1.55 - Brain - Hippocampus1.42 - Brain - Putamen (basal ganglia)1.38 - Brain - Hypothalamus1.32 - Brain - Spinal cord (cervical c-1)1.32 - Fallopian Tube1.31 - Brain - Anterior cingulate cortex (BA24)1.28 - Colon - Transverse1.26 - Brain - Frontal Cortex (BA9)1.24 - Brain - Cortex1.2 - Brain - Nucleus accumbens (basal ganglia)1.16 - Testis1.09 - Pituitary1.09 - Vagina1.07 - Brain - Caudate (basal ganglia)1.07 - Esophagus - Muscularis0.97 - Esophagus - Gastroesophageal Junction0.94 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (26) - GO:0001916 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001916) - GO:0002860 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002860) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) - GO:0009615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009615) - GO:0010224 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010224) - GO:0016477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477) - GO:0032496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032496) - GO:0032700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032700) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032816) - GO:0032946 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032946) - GO:0034393 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034393) - GO:0035722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035722) - GO:0042531 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042531) - GO:0045785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045785) - GO:0045954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045954) - GO:0048662 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048662) - GO:0050671 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050671) - GO:0050709 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050709) - GO:0050830 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050830) - GO:0051135 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051135) - GO:0097191 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097191) - GO:0098586 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098586) - GO:1900747 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900747) - GO:1903588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903588) And 1 more, listed on the interactive page. ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0031906 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031906) - GO:0043514 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043514) ### Molecular functions (6) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083) - GO:0042163 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042163) - GO:0045513 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045513) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) ## Related records ### Trials (248) - A Clinical Study of AK101 in Subjects With Moderate to Severe Plaque Psoriasis - A Direct Head-to-head Comparison of Ustekinumab with Infliximab for the Treatment of Ulcerative Colitis - A Double-blind Study to Compare the Efficacy, Safety, and Immunogenicity of the Proposed Biosimilar Ustekinumab FYB202 to Stelara® in Patients With Moderate-to-Severe Plaque Psoriasis - A Long-term Extension Study of Ustekinumab in Pediatric Participants - A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU) - A Multicentered Prospective Cohort Study of Chinese IBD Patients - A Pharmacokinetic Study Comparing EG12014 and Herceptin (Trastuzumab) in Healthy Male Volunteers - A Pharmacokinetic Study of Single-Dose Intravenous Ustekinumab Delivered in 2 Different Liquid in Vial Formulations - A Pharmacokinetic Study of Ustekinumab in Pediatric Subjects With Moderately to Severely Active Crohn's Disease - A Phase 2a, Efficacy and Safety Study of Ustekinumab in Systemic Lupus Erythematosus - A Phase 3 Study of Efficacy and Safety of AK101 in Subjects With Psoriasis - A Phase 3 Trial to Look at the Safety and Effectiveness of Ustekinumab in Korean and Taiwanese Subjects With Moderate to Severe Plaque-type Psoriasis - A Phase I Study to Compare Abcertin and EU-sourced Cerezyme® in Healthy Volunteers - A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa - A QT/QTc Evaluation Study of TS-172 in Healthy Adult Subjects - A Randomized Phase 3 Study to Evaluate Two Formulations of Romosozumab in Postmenopausal Women With Osteoporosis - A Retrospective Observational Study of Ustekinumab Among Bio-naive Participants With Crohn's Disease in China - A Safety and Effectiveness Study of CNTO 1275 in Patients With Moderate to Severe Plaque-type Psoriasis - A Safety and Efficacy Study of CNTO1275 in Patients With Multiple Sclerosis - A Safety and Efficacy Study of Ustekinumab in Patients With Plaque Psoriasis Who Have Had an Inadequate Response to Methotrexate ### Drugs (3) - Briakinumab Interleukin-12 inhibitor - Ebdarokimab Interleukin-12 inhibitor - [Ustekinumab](https://trialight.com/data/asset/ustekinumab-323cb2e2-e906-4997-ac57-d82c7f7c399d.md) Interleukin-12 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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