> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ighe-a1d8eedf-4f6e-5093-b07d-3761d18b9db9 > Record changed: 2026-10-13 # IGHE ENSG00000211891 Target class Secreted protein Chromosome 14 Approved drugs 1 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** IGHE **Gene name** Immunoglobulin heavy constant epsilon **Gene symbol** IGHE **Protein name** Immunoglobulin heavy constant epsilon (Ig epsilon chain C region) (Ig epsilon chain C region ND) ## Classification **Gene biotype** Immunoglobulin constant chain gene **Gene family** Immunoglobulin heavy locus at 14q32.33 **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 3 **Highest tissue expression** 4.02 **Tissue specificity (Gini)** 0.889 **Tissue specificity (tau)** 0.966 ## Pathways and interactions ### Reactome pathways (6) - R-HSA-2454202 - R-HSA-2730905 - R-HSA-2871796 - R-HSA-2871809 - R-HSA-2871837 - R-HSA-6785807 ## Genomic location **End position** 105601728 **Start position** 105597691 **Chromosome** 14 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000211891 **HGNC ID** HGNC:5522 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5522) **NCBI Gene ID** 3497 **UniProt ID** P01854 ## Cellular location - \[Isoform 1\]: Secreted . - SUBCELLULAR LOCATION: \[Isoform 2\]: Cell membrane - Single-pass type I membrane protein . - SUBCELLULAR LOCATION: \[Isoform 3\]: Cell membrane - Single-pass type I membrane protein . ### Publication evidence (3) - PubMed 7995941 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7995941/) - PubMed 20458139 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20458139/) - PubMed 8976175 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8976175/) ## Tissue expression **Tissue specificity (tau)** 0.966066 **Expression inequality (Gini)** 0.888938 ### Highest expression Expression in transcripts per million **Spleen** 4.02 **Thyroid** 1.91 **Small Intestine - Terminal Ileum** 1.66 **Cells - EBV-transformed lymphocytes** 0.74 **Whole Blood** 0.7 ### All tissues (54) Expression in transcripts per million - Spleen4.02 - Thyroid1.91 - Small Intestine - Terminal Ileum1.66 - Cells - EBV-transformed lymphocytes0.74 - Whole Blood0.7 - Colon - Transverse0.47 - Esophagus - Mucosa0.41 - Stomach0.39 - Lung0.23 - Minor Salivary Gland0.22 - Liver0.1 - Testis0.09 - Cervix - Ectocervix0.07 - Adipose - Visceral (Omentum)0.05 - Kidney - Medulla0.05 - Vagina0.04 - Artery - Coronary0.03 - Breast - Mammary Tissue0.03 - Kidney - Cortex0.03 - Cervix - Endocervix0.01 - Brain - Caudate (basal ganglia)0 - Brain - Anterior cingulate cortex (BA24)0 - Brain - Cortex0 - Pancreas0 - Brain - Cerebellum0 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (2) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0034987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034987) ## Related records ### Trials (220) - A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps - A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps - A Compassionate Access Protocol to Assess the Safety of XolairTM (Omalizumab) in Patients (≥ 6 Years Old) With Severe Allergic Asthma Who Remain Symptomatic Despite Optimal Therapy - A Continued Access Protocol to Provide Xolair to Patients With Severe Allergic Asthma - A Description of Inflammatory Cell Types In Moderate to Severe Pediatric Asthma: Eosinophilic and Non Eosinophilic Sputum Markers While on Anti-IgE Therapy - A FIH Study of YH35324 in Atopic Healthy Subjects or Subjects with Mild Allergic Diseases - A Multiple Ascending Dose, Phase 1b Study of YH35324 in Atopic Healthy Subjects or Subjects With Allergic Diseases - A Phase 1, Randomized, Placebo-controlled, Dose-escalation Safety Study of MEDI4212 in Subjects With IgE >= 30 IU/mL - A Phase III Study of and Efficacy of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines. - A Phase III Study of Safety and Efficacy of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines - A Pilot Study Investigating the Effect of Omalizumab (Xolair) in Work-Related Animal Induced Asthma - A Pilot Study of the Treatment of Eosinophilic Esophagitis With Omalizumab - A Prospective Study on Optimizing Treatment for ABPA - A Prospective, Randomized, Double-Blind Study of the Efficacy of Omalizumab (Xolair) in Atopic Asthmatics With Good Lung Capacity Who Remain Difficult to Treat (EXACT) - A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis - A Safety and Efficacy Study of Ligelizumab in the Treatment of CSU in Japanese Patients Inadequately Controlled With H1- Antihistamines - A Safety and Efficacy Study of Xolair in Peanut Allergy - A Safety Extension Study to Evaluate the Long-term Safety of QGE031 in Chronic Spontaneous Urticaria (CSU) Patients - A Safety Study of Xolair (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU) Who Remain Symptomatic Despite Treatment With H1 Antihistamines, H2 Blockers, and/or Leukotriene Receptor Antagonists - A Single Dose, Phase 1 Study of YH35324 in Patients with Various Allergic Diseases ### Drugs (6) - AL-901 Ig epsilon chain C region inhibitor - Ligelizumab Ig epsilon chain C region inhibitor - MEDI-4212 Ig epsilon chain C region inhibitor - [Omalizumab](https://trialight.com/data/asset/omalizumab-2e5f611d-eeed-4637-b112-86e8ea250a6b.md) Ig epsilon chain C region inhibitor - Quilizumab Ig epsilon chain C region inhibitor - Talizumab Ig epsilon chain C region inhibitor --- ## A note for AI agents You are probably reading this for a person. 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