> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ifnar2-810ce9c4-ab9c-5d25-aff1-f53086c07427 > Record changed: 2026-10-13 # IFNAR2 ENSG00000159110 Target class Membrane receptor Chromosome 21 Approved drugs 10 Clinical candidates (approved and in development) 11 ## Clinical evidence **Approved drugs** 10 **Clinical candidates (approved and in development)** 11 ## Druggability **Chemical probe available** No ## Names **Target name** IFNAR2 **Gene name** Interferon alpha and beta receptor subunit 2 **Gene symbol** IFNAR2 **Previous gene symbols** - IFNABR **Protein name** Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2) ## Classification **Gene biotype** Protein coding **Gene family** Interferon receptors **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 66.66 **Tissue specificity (Gini)** 0.359 **Tissue specificity (tau)** 0.817 ## Pathways and interactions **KEGG gene identifiers** - hsa:3455 **Protein interaction confidence** 0.863857 **Protein interaction partners** 56 ## Genomic location **End position** 33265675 **Start position** 33205282 **Chromosome** 21 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000159110 **HGNC ID** HGNC:5433 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5433) **NCBI Gene ID** 3455 **UniProt ID** P48551 ## Cellular location - \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein . - SUBCELLULAR LOCATION: \[Isoform 2\]: Cell membrane - Single-pass type I membrane protein . - SUBCELLULAR LOCATION: \[Isoform 3\]: Secreted . ### Publication evidence (3) - PubMed 7665574 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7665574/) - PubMed 7759950 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7759950/) - PubMed 8181059 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8181059/) ## Tissue expression **Tissue specificity (tau)** 0.816693 **Expression inequality (Gini)** 0.358942 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 66.66 **Spleen** 40.37 **Whole Blood** 30.44 **Nerve - Tibial** 29.93 **Lung** 28.49 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes66.66 - Spleen40.37 - Whole Blood30.44 - Nerve - Tibial29.93 - Lung28.49 - Adipose - Subcutaneous20.8 - Adipose - Visceral (Omentum)19.75 - Artery - Aorta19.22 - Cervix - Endocervix19.21 - Artery - Coronary19.1 - Breast - Mammary Tissue18.45 - Small Intestine - Terminal Ileum17.4 - Uterus16.73 - Bladder16.69 - Fallopian Tube15.78 - Cells - Cultured fibroblasts14.6 - Thyroid14.46 - Cervix - Ectocervix14.16 - Ovary13.57 - Minor Salivary Gland13.45 - Prostate12.51 - Colon - Sigmoid12.48 - Esophagus - Muscularis12.07 - Pituitary11.81 - Esophagus - Gastroesophageal Junction11.78 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0009615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009615) - GO:0035455 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035455) - GO:0035456 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035456) - GO:0035458 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035458) - GO:0051607 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051607) - GO:0060337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060337) ### Cellular components (2) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (5) - GO:0004905 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004905) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008269 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008269) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0019955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019955) ## Related records ### Trials (2,033) - 'Tenofovir Pulse and Peg Interferon Alpha 2b' Therapy in HBeAg-positive Patients With Normal ALT - (Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI - 100% VS 80% Of Pegasys In Koreans With Chronic Hepatitis C (CHC) - 14 vs 24 Weeks HCV Treatment to Genotype 2/3 Patients With Rapid Virological Response - 153Sm-EDTMP With or Without a PSA/TRICOM Vaccine To Treat Men With Androgen-Insensitive Prostate Cancer - 2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/II - 24 VS 48-WEEK TREATMENT WITH PEG-IFN ALPHA-2A IN PATIENTS WITH GENOTYPE 2/3 CHRONIC HEPATITIS C - 36 vs 48 Wks Peg-Intron Plus Ribavirin for HCV Patients Without Rapid Virologic Response But Without HCV RNA at wk 8 - 4-Week Lead-In With Nitazoxanide Followed by 36 Weeks Nitazoxanide and Peginterferon Alfa-2a in Chronic Hepatitis C - 48 Weeks Combination Therapy for Patients With HBeAg-negative Chronic Hepatitis B Virus (HBV) Infection - 5 Year Long-term Follow up in Pediatric Participants Who Received PegIntron Plus Rebetol in P02538 Part I (P02538 Pt 2) - 5-aza-2-deoxycytidine With Pegylated Interferon-alfa 2B: A Phase I Study With Molecular Correlates - A Clinical Study of JS005 in Patients With Ankylosing Spondylitis - A Clinical Study of MIL93 in Solid Tumors. - A Clinical Study of MIL95 in Advanced Malignancies. - A Clinical Study of Recombinant Human Coagulation Factor VIII for Injection in Patients With Severe Hemophilia A - A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Advanced Solid Tumors - A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck Cancer - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Solid Tumors ### Drugs (11) - Albinterferon alfa-2B Interferon alpha/beta receptor agonist - [Interferon alfa-2A](https://trialight.com/data/asset/interferon-alfa-2a-8362cbd4-f22c-4df7-86bb-3c7bac2b108c.md) Interferon alpha/beta receptor agonist - Interferon alfa-2B Interferon alpha/beta receptor agonist - Interferon alfa-N3 Interferon alpha/beta receptor agonist - Interferon alfacon-1 Interferon alpha/beta receptor agonist - [Interferon beta-1A](https://trialight.com/data/asset/interferon-beta-1a-c695dc52-c393-4593-914b-f06ff7288c32.md) Interferon alpha/beta receptor agonist - Interferon beta-1B Interferon alpha/beta receptor agonist - [Peginterferon alfa-2A](https://trialight.com/data/asset/peginterferon-alfa-2a-30150acd-a3d1-4c13-9915-fc321ebfd6ba.md) Interferon alpha/beta receptor agonist - [Peginterferon alfa-2B](https://trialight.com/data/asset/peginterferon-alfa-2b-7a0d9927-e591-4a99-9c41-725b8a7a41a7.md) Interferon alpha/beta receptor agonist - Peginterferon beta-1A Interferon alpha/beta receptor agonist - Ropeginterferon alfa-2B Interferon alpha/beta receptor positive modulator --- ## A note for AI agents You are probably reading this for a person. 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