> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ifnar1-b87a0a08-6346-52f4-927e-c5d552c5babd > Record changed: 2026-10-13 # IFNAR1 ENSG00000142166 Target class Membrane receptor Chromosome 21 Approved drugs 11 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 11 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** No ## Names **Other names** - IFRC **Target name** IFNAR1 **Gene name** Interferon alpha and beta receptor subunit 1 **Gene symbol** IFNAR1 **Previous gene symbols** - IFNAR **Protein name** Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) ## Classification **Gene biotype** Protein coding **Gene family** Interferon receptors **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 32.98 **Tissue specificity (Gini)** 0.2 **Tissue specificity (tau)** 0.455 ## Pathways and interactions **KEGG gene identifiers** - hsa:3454 **Protein interaction confidence** 0.86 **Protein interaction partners** 80 ### Reactome pathways (5) - R-HSA-909733 - R-HSA-912694 - R-HSA-9679191 - R-HSA-9705671 - R-HSA-9833109 ## Genomic location **End position** 33359864 **Start position** 33324387 **Chromosome** 21 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000142166 **HGNC ID** HGNC:5432 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5432) **NCBI Gene ID** 3454 **UniProt ID** P17181 ## Cellular location - \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein . Late endosome . Lysosome . Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. . ### Publication evidence (5) - PubMed 14532120 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14532120/) - PubMed 18056411 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18056411/) - PubMed 2153461 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2153461/) - PubMed 35442418 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35442418/) - PubMed 7665574 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7665574/) ## Tissue expression **Tissue specificity (tau)** 0.455233 **Expression inequality (Gini)** 0.199531 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 32.98 **Adipose - Visceral (Omentum)** 28.93 **Adipose - Subcutaneous** 28.85 **Lung** 28.22 **Nerve - Tibial** 27.99 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts32.98 - Adipose - Visceral (Omentum)28.93 - Adipose - Subcutaneous28.85 - Lung28.22 - Nerve - Tibial27.99 - Artery - Coronary27.2 - Cells - EBV-transformed lymphocytes26.7 - Thyroid26.35 - Spleen25.58 - Cervix - Endocervix25.16 - Breast - Mammary Tissue24.4 - Bladder23.7 - Whole Blood23.49 - Artery - Tibial23.46 - Artery - Aorta23.08 - Fallopian Tube22.98 - Ovary22.56 - Uterus22.09 - Cervix - Ectocervix20.84 - Brain - Spinal cord (cervical c-1)20.49 - Prostate20.49 - Minor Salivary Gland20.19 - Liver19.78 - Colon - Sigmoid18.46 - Kidney - Medulla18.32 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0009615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009615) - GO:0035458 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035458) - GO:0060337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060337) - GO:1901857 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901857) ### Cellular components (3) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0005770 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005770) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (4) - GO:0004905 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004905) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008269 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008269) - GO:0019955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019955) ## Related records ### Trials (2,111) - 'Tenofovir Pulse and Peg Interferon Alpha 2b' Therapy in HBeAg-positive Patients With Normal ALT - (Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI - 100% VS 80% Of Pegasys In Koreans With Chronic Hepatitis C (CHC) - 14 vs 24 Weeks HCV Treatment to Genotype 2/3 Patients With Rapid Virological Response - 153Sm-EDTMP With or Without a PSA/TRICOM Vaccine To Treat Men With Androgen-Insensitive Prostate Cancer - 2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/II - 24 VS 48-WEEK TREATMENT WITH PEG-IFN ALPHA-2A IN PATIENTS WITH GENOTYPE 2/3 CHRONIC HEPATITIS C - 36 vs 48 Wks Peg-Intron Plus Ribavirin for HCV Patients Without Rapid Virologic Response But Without HCV RNA at wk 8 - 4-Week Lead-In With Nitazoxanide Followed by 36 Weeks Nitazoxanide and Peginterferon Alfa-2a in Chronic Hepatitis C - 48 Weeks Combination Therapy for Patients With HBeAg-negative Chronic Hepatitis B Virus (HBV) Infection - 5 Year Long-term Follow up in Pediatric Participants Who Received PegIntron Plus Rebetol in P02538 Part I (P02538 Pt 2) - 5-aza-2-deoxycytidine With Pegylated Interferon-alfa 2B: A Phase I Study With Molecular Correlates - A Clinical Study of JS005 in Patients With Ankylosing Spondylitis - A Clinical Study of MIL93 in Solid Tumors. - A Clinical Study of MIL95 in Advanced Malignancies. - A Clinical Study of Recombinant Human Coagulation Factor VIII for Injection in Patients With Severe Hemophilia A - A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps. - A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Advanced Solid Tumors - A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck Cancer - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors ### Drugs (12) - Albinterferon alfa-2B Interferon alpha/beta receptor agonist - [Anifrolumab](https://trialight.com/data/asset/anifrolumab-4df440fe-efd0-44aa-828f-ea4381468125.md) Interferon-alpha/beta receptor alpha chain antagonist - [Interferon alfa-2A](https://trialight.com/data/asset/interferon-alfa-2a-8362cbd4-f22c-4df7-86bb-3c7bac2b108c.md) Interferon alpha/beta receptor agonist - Interferon alfa-2B Interferon alpha/beta receptor agonist - Interferon alfa-N3 Interferon alpha/beta receptor agonist - Interferon alfacon-1 Interferon alpha/beta receptor agonist - [Interferon beta-1A](https://trialight.com/data/asset/interferon-beta-1a-c695dc52-c393-4593-914b-f06ff7288c32.md) Interferon alpha/beta receptor agonist - Interferon beta-1B Interferon alpha/beta receptor agonist - [Peginterferon alfa-2A](https://trialight.com/data/asset/peginterferon-alfa-2a-30150acd-a3d1-4c13-9915-fc321ebfd6ba.md) Interferon alpha/beta receptor agonist - [Peginterferon alfa-2B](https://trialight.com/data/asset/peginterferon-alfa-2b-7a0d9927-e591-4a99-9c41-725b8a7a41a7.md) Interferon alpha/beta receptor agonist - Peginterferon beta-1A Interferon alpha/beta receptor agonist - Ropeginterferon alfa-2B Interferon alpha/beta receptor positive modulator --- ## A note for AI agents You are probably reading this for a person. 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