> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/htr7-8ff71150-41e0-5fc2-91f5-8be759db72fc
> Record changed: 2026-11-04

# HTR7

ENSG00000148680

Target class

GPCR

Chromosome

10

Approved drugs

3

Clinical candidates (approved and in development)

5

## Clinical evidence

**Approved drugs**

3

**Clinical candidates (approved and in development)**

5

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- 5-HT7

**Target name**

HTR7

**Gene name**

5-hydroxytryptamine receptor 7

**Gene symbol**

HTR7

**Protein name**

5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7)

## Classification

**Gene biotype**

Protein coding

**Gene family**

5-hydroxytryptamine receptors, G protein-coupled

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

8

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

13.83

**Tissue specificity (Gini)**

0.647

**Tissue specificity (tau)**

0.958

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3363

**Protein interaction confidence**

0.892333

**Protein interaction partners**

24

### Reactome pathways (2)

- R-HSA-390666
- R-HSA-418555

## Genomic location

**End position**

90858039

**Start position**

90740823

**Chromosome**

10

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000148680

**HGNC ID**

HGNC:5302

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5302)

**NCBI Gene ID**

3363

**UniProt ID**

P34969

## Cellular location

- Cell membrane
- Multi-pass membrane protein .
- Nucleoplasm
- Plasma membrane
- Primary cilium

### Publication evidence (2)

- PubMed 22448645  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22448645/)
- PubMed 35714614  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35714614/)

## Tissue expression

**Tissue specificity (tau)**

0.958335

**Expression inequality (Gini)**

0.64708

### Highest expression

Expression in transcripts per million

**Testis**

13.83

**Cells - Cultured fibroblasts**

4.34

**Artery - Aorta**

2.49

**Bladder**

1.71

**Brain - Hypothalamus**

1.7

### All tissues (54)

Expression in transcripts per million

- Testis13.83
- Cells - Cultured fibroblasts4.34
- Artery - Aorta2.49
- Bladder1.71
- Brain - Hypothalamus1.7
- Artery - Coronary1.5
- Brain - Anterior cingulate cortex (BA24)1.29
- Vagina1.01
- Small Intestine - Terminal Ileum0.99
- Adipose - Subcutaneous0.89
- Brain - Frontal Cortex (BA9)0.83
- Stomach0.82
- Nerve - Tibial0.8
- Skin - Sun Exposed (Lower leg)0.73
- Esophagus - Mucosa0.71
- Artery - Tibial0.59
- Breast - Mammary Tissue0.57
- Brain - Cortex0.57
- Brain - Hippocampus0.48
- Colon - Transverse0.45
- Colon - Sigmoid0.45
- Lung0.45
- Prostate0.43
- Minor Salivary Gland0.43
- Cervix - Endocervix0.4

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (5)

- GO:0007187  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187)
- GO:0007192  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007192)
- GO:0007268  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268)
- GO:0007623  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007623)
- GO:0008015  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008015)

### Cellular components (3)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005929  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005929)
- GO:0032588  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032588)

### Molecular functions (2)

- GO:0004993  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004993)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## On-target safety

- decreased inflammation  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased inflammation  
### Biological samples (2)

  - nervous system
  - immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased/decreased memory  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased/decreased memory  
### Biological samples (2)

  - nervous system
  - immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased body temperature  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased body temperature  
### Biological samples (2)

  - nervous system
  - immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased anxiety  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased anxiety  
### Biological samples (2)

  - nervous system
  - immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (2)

  - nervous system
  - immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased/increased pain  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased/increased pain  
### Biological samples (2)

  - nervous system
  - immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased sleep  
### Effects (2)

  - Inhibition/Decrease/Downregulation: acute
  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased sleep  
### Biological samples (2)

  - nervous system
  - immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased memory  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased memory  
### Biological samples (2)

  - nervous system
  - immune  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- receptor binding  
### Studies

  - biochemical: NVS\_GPCR\_h5HT7, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_h5HT7 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (1,449)

- "Brexpiprazole (Rexulti™) Safety and Efficacy Among Filipino Patients (RAISE) - A Post Marketing Surveillance Program"
- "Extended" (Alternate Day) Antipsychotic Dosing
- "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)"
- \[11C\]Yohimbine PET Study of alpha2-AR
- 1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain
- 12 Week Open, Non-Comparative Switch Study Of Oral Ziprazidone In Previously Treated Schizophrenic Patients
- 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated
- 18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder
- 24-Hour Time Course of Striatal Dopamine D2 Receptor Occupancy of Ziprasidone: A PET Study
- 28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years
- 3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008)
- 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009)
- 3-week Study to Evaluate Efficacy and Safety of Ziprasidone With Either Lithium or Divalproex in Acutely Manic Subjects
- 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857)
- 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia
- 5HT3 Antagonism and Auditory Gating in Schizophrenia
- 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777)
- 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772)
- 9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED)
- A 10-Week, Open-Label, Flexible Dose Adaptive Study Evaluating the Efficacy of Vortioxetine in Subjects With Panic Disorder

### Drugs (40)

- Amisulpride Serotonin (5-HT) receptor antagonist
- Brexpiprazole
- Capeserod
- Chlorpromazine
- Clozapine
- Cyamemazine
- Cyproheptadine
- Dexfenfluramine Serotonin (5-HT) receptor agonist
- Dexfenfluramine hydrochloride Serotonin (5-HT) receptor agonist
- Dihydroergotamine
- Fluperlapine
- Fluphenazine
- Haloperidol
- Iloperidone
- JNJ-18038683 Serotonin 7 (5-HT7) receptor antagonist
- JNJ-18038683 FREE BASE Serotonin 7 (5-HT7) receptor antagonist
- Ketanserin
- Lurasidone
- LY2590443 Serotonin 7 (5-HT7) receptor antagonist
- Mesulergine

---

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