> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/htr6-0c94e40d-000e-5925-b943-2b88a287fd53 > Record changed: 2026-11-04 # HTR6 ENSG00000158748 Target class GPCR Chromosome 1 Approved drugs 3 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Target name** HTR6 **Gene name** 5-hydroxytryptamine receptor 6 **Gene symbol** HTR6 **Protein name** 5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6) ### Other names (2) - 5-HT6 - 5-HT6R ## Classification **Gene biotype** Protein coding **Gene family** 5-hydroxytryptamine receptors, G protein-coupled **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Highest tissue expression** 4.45 **Tissue specificity (Gini)** 0.79 **Tissue specificity (tau)** 0.943 ## Pathways and interactions **KEGG gene identifiers** - hsa:3362 **Protein interaction confidence** 0.887385 **Protein interaction partners** 13 ### Reactome pathways (2) - R-HSA-390666 - R-HSA-418555 ## Genomic location **End position** 19680966 **Start position** 19664875 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000158748 **HGNC ID** HGNC:5301 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5301) **NCBI Gene ID** 3362 **UniProt ID** P50406 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 37327704 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37327704/) - PubMed 35714614 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35714614/) - PubMed 36989299 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36989299/) ## Tissue expression **Tissue specificity (tau)** 0.943439 **Expression inequality (Gini)** 0.790405 ### Highest expression Expression in transcripts per million **Brain - Nucleus accumbens (basal ganglia)** 4.45 **Brain - Caudate (basal ganglia)** 3.11 **Brain - Putamen (basal ganglia)** 2.06 **Brain - Cortex** 1.77 **Brain - Frontal Cortex (BA9)** 1.6 ### All tissues (54) Expression in transcripts per million - Brain - Nucleus accumbens (basal ganglia)4.45 - Brain - Caudate (basal ganglia)3.11 - Brain - Putamen (basal ganglia)2.06 - Brain - Cortex1.77 - Brain - Frontal Cortex (BA9)1.6 - Brain - Anterior cingulate cortex (BA24)0.76 - Brain - Hypothalamus0.42 - Testis0.38 - Cervix - Endocervix0.27 - Cells - EBV-transformed lymphocytes0.24 - Pituitary0.23 - Brain - Hippocampus0.23 - Brain - Amygdala0.21 - Cervix - Ectocervix0.12 - Colon - Sigmoid0.1 - Prostate0.1 - Vagina0.1 - Small Intestine - Terminal Ileum0.09 - Uterus0.09 - Brain - Substantia nigra0.08 - Skin - Not Sun Exposed (Suprapubic)0.08 - Spleen0.08 - Skin - Sun Exposed (Lower leg)0.08 - Artery - Tibial0.08 - Artery - Aorta0.08 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0007192 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007192) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) - GO:0032008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032008) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0004969 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004969) - GO:0004993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004993) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## On-target safety - reduced appetite ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - weight loss ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Off-target safety - receptor binding ### Studies - biochemical: NVS\_GPCR\_h5HT6, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_h5HT6 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,639) - 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug - "Extended" (Alternate Day) Antipsychotic Dosing - "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)" - 1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain - 12-Month Open-Label Extension Study of Intepirdine (RVT-101) in Subjects With Alzheimer's Disease: MINDSET Extension - 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated - 28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years - 3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008) - 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009) - 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857) - 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777) - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772) - 6-week Study Treatment to Evaluate the Safety and Effectiveness of AZD2066 in Patients With Major Depressive Disorder - 9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED) - A 10-Week, Open-Label, Flexible Dose Adaptive Study Evaluating the Efficacy of Vortioxetine in Subjects With Panic Disorder - A 4-week Study of Mifepristone in the Prevention of Risperidone-induced Weight Gain in Healthy Male Volunteers - A 6 Month Study to Compare the Metabolic Effects of Paliperidone ER and Olanzapine in Patients With Schizophrenia - A Bioequivalence Study of the Lu AA21004 20 mg and 2×10 mg Tablets - A Clinical Study of the Safety and Efficacy of Chemogenetics Therapy in the Treatment of Parkinson's Disease ### Drugs (45) - Amisulpride Serotonin (5-HT) receptor antagonist - Amitriptyline - Amoxapine - Bromocriptine - Capeserod - Cerlapirdine Serotonin 6 (5-HT6) receptor antagonist - Cerlapirdine hydrochloride Serotonin 6 (5-HT6) receptor antagonist - Chlorpromazine - Clozapine - Cyproheptadine - Dexfenfluramine Serotonin (5-HT) receptor agonist - Dexfenfluramine hydrochloride Serotonin (5-HT) receptor agonist - Donitriptan - Duloxetine - Ergotamine - Fluperlapine - Fluphenazine - Idalopirdine Serotonin 6 (5-HT6) receptor antagonist - Iloperidone - Intepirdine Serotonin 6 (5-HT6) receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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