> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/htr2c-9cedb114-3d17-55cd-8571-6b4398b0f46f > Record changed: 2026-10-13 # HTR2C ENSG00000147246 Target class GPCR Chromosome X Approved drugs 30 Clinical candidates (approved and in development) 34 ## Clinical evidence **Approved drugs** 30 **Clinical candidates (approved and in development)** 34 ## Druggability **Chemical probe available** Yes ## Names **Target name** HTR2C **Gene name** 5-hydroxytryptamine receptor 2C **Gene symbol** HTR2C **Previous gene symbols** - HTR1C **Protein name** 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C) ### Other names (2) - 5-HT2C - 5HTR2C ## Classification **Gene biotype** Protein coding **Gene family** 5-hydroxytryptamine receptors, G protein-coupled|MicroRNA protein coding host genes|Small nucleolar RNA protein coding host genes **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 9 **Highest tissue expression** 31.82 **Tissue specificity (Gini)** 0.917 **Tissue specificity (tau)** 0.974 ## Pathways and interactions **KEGG gene identifiers** - hsa:3358 **Protein interaction confidence** 0.861955 **Protein interaction partners** 22 ### Reactome pathways (2) - R-HSA-390666 - R-HSA-416476 ## Genomic location **End position** 114910061 **Start position** 114584078 **Chromosome** X **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000147246 **HGNC ID** HGNC:5295 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5295) **NCBI Gene ID** 3358 **UniProt ID** P28335 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (4) - PubMed 12970106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12970106/) - PubMed 18703043 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18703043/) - PubMed 19057895 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19057895/) - PubMed 7895773 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7895773/) ## Tissue expression **Tissue specificity (tau)** 0.973845 **Expression inequality (Gini)** 0.916675 ### Highest expression Expression in transcripts per million **Brain - Nucleus accumbens (basal ganglia)** 31.82 **Brain - Caudate (basal ganglia)** 13.82 **Brain - Hypothalamus** 13.27 **Brain - Putamen (basal ganglia)** 6.38 **Brain - Amygdala** 2.61 ### All tissues (54) Expression in transcripts per million - Brain - Nucleus accumbens (basal ganglia)31.82 - Brain - Caudate (basal ganglia)13.82 - Brain - Hypothalamus13.27 - Brain - Putamen (basal ganglia)6.38 - Brain - Amygdala2.61 - Brain - Anterior cingulate cortex (BA24)1.71 - Brain - Frontal Cortex (BA9)1.37 - Brain - Hippocampus1.32 - Brain - Substantia nigra1.29 - Brain - Cortex0.73 - Brain - Spinal cord (cervical c-1)0.6 - Vagina0.32 - Brain - Cerebellar Hemisphere0.11 - Cervix - Ectocervix0.11 - Cervix - Endocervix0.09 - Testis0.09 - Brain - Cerebellum0.08 - Nerve - Tibial0.07 - Bladder0.06 - Prostate0.04 - Pituitary0.02 - Skin - Sun Exposed (Lower leg)0.01 - Minor Salivary Gland0.01 - Esophagus - Gastroesophageal Junction0 - Kidney - Cortex0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006874 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006874) - GO:0007208 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007208) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) - GO:0007631 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007631) - GO:0010513 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010513) - GO:0051209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051209) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0098664 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098664) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0098666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098666) ### Molecular functions (6) - GO:0001587 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001587) - GO:0004993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004993) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0051378 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051378) - GO:0071886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071886) ## On-target safety - increased convulsions ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased convulsions ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased locomotor activity ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased locomotor activity ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased anxiety ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased anxiety ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased memory ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased memory ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - abnormal mouth movements ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: abnormal mouth movements ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - penile erection ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: penile erection ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased convulsions ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased convulsions ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased eating ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased eating ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Increased, Kidney Failure ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/33) - drug abuse/dependence ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: drug abuse/dependence ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased memory ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased memory ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased anxiety ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased anxiety ### Biological samples - nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (1,487) - "Extended" (Alternate Day) Antipsychotic Dosing - "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)" - 1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain - 12-Month Open-Label Long-term Safety Study of TNX-102 SL Tablets in Fibromyalgia Patients - 12-Week Open-Label Extension Study of TNX-102 SL in PTSD Patients - 15 mg Mirtazapine Orally Disintegrating Tablets, Fasting - 15 mg Mirtazapine Orally Disintegrating Tablets, Non-Fasting - 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated - 28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years - 3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008) - 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009) - 3-week Study to Evaluate Efficacy and Safety of Ziprasidone With Either Lithium or Divalproex in Acutely Manic Subjects - 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857) - 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia - 5HT2CR Balance in Brain Connectivity in Cocaine Dependence - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777) - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772) - 9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED) - A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive Disorder - A 2-Part Study to Investigate the Dose-Ranging Safety and Pharmacokinetics, Followed by the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution as an Adjunctive Therapy in Children ≥ 2 Years Old and Young Adults With Dravet Syndrome ### Drugs (50) - Agomelatine Serotonin 2c (5-HT2c) receptor antagonist - Amisulpride Serotonin (5-HT) receptor antagonist - Carphenazine Serotonin 2c (5-HT2c) receptor antagonist - Carphenazine maleate Serotonin 2c (5-HT2c) receptor antagonist - Chlorprothixene Serotonin 2c (5-HT2c) receptor antagonist - Clothiapine Serotonin 2 (5-HT2) receptor antagonist - [Cyclobenzaprine](https://trialight.com/data/asset/cyclobenzaprine-b63a35b9-14ef-4262-8b87-59a3229076ce.md) Serotonin 2c (5-HT2c) receptor antagonist - Cyclobenzaprine hydrochloride Serotonin 2c (5-HT2c) receptor antagonist - Dexfenfluramine Serotonin (5-HT) receptor agonist - Dexfenfluramine hydrochloride Serotonin (5-HT) receptor agonist - Esmirtazapine Serotonin 2c (5-HT2c) receptor antagonist - Esmirtazapine maleate Serotonin 2c (5-HT2c) receptor antagonist - Fenfluramine Serotonin 2c (5-HT2c) receptor agonist - Fenfluramine hydrochloride Serotonin 2c (5-HT2c) receptor agonist - Lorcaserin Serotonin 2c (5-HT2c) receptor agonist - Lorcaserin hydrochloride Serotonin 2c (5-HT2c) receptor agonist - Loxapine Serotonin 2c (5-HT2c) receptor antagonist - Loxapine hydrochloride Serotonin 2c (5-HT2c) receptor antagonist - Loxapine succinate Serotonin 2c (5-HT2c) receptor antagonist - Methixene Serotonin 2c (5-HT2c) receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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