> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/htr1f-ca35809f-6711-5309-ab87-0822fde06269 > Record changed: 2026-11-04 # HTR1F ENSG00000179097 Target class GPCR Chromosome 3 Approved drugs 7 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** Yes ## Names **Target name** HTR1F **Gene name** 5-hydroxytryptamine receptor 1F **Gene symbol** HTR1F **Protein name** 5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F) ### Other names (2) - HTR1EL - 5-HT1F ## Classification **Gene biotype** Protein coding **Gene family** 5-hydroxytryptamine receptors, G protein-coupled **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 1.28 **Tissue specificity (Gini)** 0.515 **Tissue specificity (tau)** 0.811 ## Pathways and interactions **KEGG gene identifiers** - hsa:3355 **Protein interaction confidence** 0.763647 **Protein interaction partners** 17 ### Reactome pathways (2) - R-HSA-390666 - R-HSA-418594 ## Genomic location **End position** 87993839 **Start position** 87792704 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000179097 **HGNC ID** HGNC:5292 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5292) **NCBI Gene ID** 3355 **UniProt ID** P30939 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 21422162 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21422162/) - PubMed 8380639 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8380639/) - PubMed 8384716 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8384716/) ## Tissue expression **Tissue specificity (tau)** 0.811468 **Expression inequality (Gini)** 0.515004 ### Highest expression Expression in transcripts per million **Adipose - Subcutaneous** 1.28 **Cervix - Ectocervix** 1 **Cervix - Endocervix** 0.89 **Breast - Mammary Tissue** 0.73 **Pituitary** 0.69 ### All tissues (54) Expression in transcripts per million - Adipose - Subcutaneous1.28 - Cervix - Ectocervix1 - Cervix - Endocervix0.89 - Breast - Mammary Tissue0.73 - Pituitary0.69 - Adipose - Visceral (Omentum)0.68 - Nerve - Tibial0.67 - Uterus0.66 - Thyroid0.51 - Lung0.46 - Fallopian Tube0.44 - Kidney - Medulla0.4 - Vagina0.35 - Testis0.35 - Brain - Frontal Cortex (BA9)0.3 - Cells - Cultured fibroblasts0.3 - Spleen0.28 - Brain - Cortex0.27 - Skin - Sun Exposed (Lower leg)0.25 - Prostate0.22 - Ovary0.22 - Brain - Anterior cingulate cortex (BA24)0.19 - Brain - Substantia nigra0.17 - Muscle - Skeletal0.15 - Brain - Amygdala0.15 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0007198 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007198) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (4) - GO:0001586 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001586) - GO:0004993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004993) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0051378 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051378) ## Related records ### Trials (1,268) - "Extended" (Alternate Day) Antipsychotic Dosing - "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)" - \[11C\]Yohimbine PET Study of alpha2-AR - 1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain - 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated - 28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years - 3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008) - 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009) - 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857) - 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777) - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772) - 9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED) - A 1-year Study in Adolescents to Assess the Long-term Safety of Almotriptan Malate When Treating Their Migraine Headaches - A 12-Month Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine - A 4-week Study of Mifepristone in the Prevention of Risperidone-induced Weight Gain in Healthy Male Volunteers - A 6 Month Study to Compare the Metabolic Effects of Paliperidone ER and Olanzapine in Patients With Schizophrenia - A Clinical Study of the Safety and Efficacy of Chemogenetics Therapy in the Treatment of Parkinson's Disease - A Clinical Trial of Lurasidone in Treatment of Schizophrenia - A Cohort Study on the Prevention of Nausea and Vomiting Induced by Concurrent Chemoradiotherapy for Lung Cancer Using Rolapitant and Palonosetron ### Drugs (31) - Almotriptan Serotonin 1f (5-HT1f) receptor agonist - Almotriptan malate Serotonin 1f (5-HT1f) receptor agonist - Amisulpride Serotonin (5-HT) receptor antagonist - Clozapine - Dexfenfluramine Serotonin (5-HT) receptor agonist - Dexfenfluramine hydrochloride Serotonin (5-HT) receptor agonist - Dihydroergotamine - Donitriptan - Eletriptan Serotonin 1f (5-HT1f) receptor agonist - Eletriptan hydrobromide Serotonin 1f (5-HT1f) receptor agonist - Ergotamine - Lasmiditan Serotonin 1f (5-HT1f) receptor agonist - Lasmiditan succinate Serotonin 1f (5-HT1f) receptor agonist - Mebufotenin - Metergoline - Methylergonovine - Methysergide - Metitepine - Naratriptan - [Olanzapine](https://trialight.com/data/asset/olanzapine-5b966c11-69ff-43ab-aefa-6c712a56b2d4.md) --- ## A note for AI agents You are probably reading this for a person. 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