> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/htr1e-1035190a-a7ec-50e1-beee-582b7615b9b7 > Record changed: 2026-11-04 # HTR1E ENSG00000168830 Target class GPCR Chromosome 6 Approved drugs 3 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Other names** - 5-HT1E **Target name** HTR1E **Gene name** 5-hydroxytryptamine receptor 1E **Gene symbol** HTR1E **Protein name** 5-hydroxytryptamine receptor 1E (5-HT-1E) (5-HT1E) (S31) (Serotonin receptor 1E) ## Classification **Gene biotype** Protein coding **Gene family** 5-hydroxytryptamine receptors, G protein-coupled **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 11 **Highest tissue expression** 5.01 **Tissue specificity (Gini)** 0.78 **Tissue specificity (tau)** 0.906 ## Pathways and interactions **KEGG gene identifiers** - hsa:3354 **Protein interaction confidence** 0.77285 **Protein interaction partners** 20 ### Reactome pathways (2) - R-HSA-390666 - R-HSA-418594 ## Genomic location **End position** 87017155 **Start position** 86936662 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000168830 **HGNC ID** HGNC:5291 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5291) **NCBI Gene ID** 3354 **UniProt ID** P28566 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (5) - PubMed 14744596 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14744596/) - PubMed 1513320 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1513320/) - PubMed 1608964 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1608964/) - PubMed 1733778 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1733778/) - PubMed 21422162 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21422162/) ## Tissue expression **Tissue specificity (tau)** 0.90615 **Expression inequality (Gini)** 0.779912 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 5.01 **Brain - Cortex** 3.49 **Brain - Nucleus accumbens (basal ganglia)** 2.7 **Brain - Anterior cingulate cortex (BA24)** 2.22 **Brain - Cerebellar Hemisphere** 2.22 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)5.01 - Brain - Cortex3.49 - Brain - Nucleus accumbens (basal ganglia)2.7 - Brain - Anterior cingulate cortex (BA24)2.22 - Brain - Cerebellar Hemisphere2.22 - Brain - Caudate (basal ganglia)2.13 - Ovary1.83 - Brain - Cerebellum1.71 - Brain - Putamen (basal ganglia)1.46 - Stomach1.4 - Brain - Hypothalamus1.02 - Testis0.75 - Brain - Amygdala0.73 - Brain - Hippocampus0.66 - Esophagus - Muscularis0.47 - Esophagus - Gastroesophageal Junction0.42 - Uterus0.42 - Thyroid0.36 - Cervix - Endocervix0.24 - Brain - Substantia nigra0.23 - Cervix - Ectocervix0.1 - Brain - Spinal cord (cervical c-1)0.08 - Colon - Sigmoid0.08 - Pituitary0.06 - Skin - Not Sun Exposed (Suprapubic)0.04 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0007198 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007198) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (5) - GO:0001586 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001586) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0004993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004993) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0051378 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051378) ## Related records ### Trials (1,337) - "Extended" (Alternate Day) Antipsychotic Dosing - "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)" - \[11C\]Yohimbine PET Study of alpha2-AR - 1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain - 12 Week Open, Non-Comparative Switch Study Of Oral Ziprazidone In Previously Treated Schizophrenic Patients - 12 Week Study of the Safety/Efficacy of Asenapine When Added to Lithium/Valproate in the Treatment of Bipolar Disorder (A7501008 / P05844 / MK-8274-017) - 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated - 24-Hour Time Course of Striatal Dopamine D2 Receptor Occupancy of Ziprasidone: A PET Study - 28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years - 3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008) - 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009) - 3-week Study to Evaluate Efficacy and Safety of Ziprasidone With Either Lithium or Divalproex in Acutely Manic Subjects - 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857) - 40 Week Trial to Study the Safety of Asenapine When Added to Lithium or Valproate in the Treatment of Bipolar Disorder (A7501009)(P05786) - 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777) - 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772) - 6-week Trial of the Efficacy and Safety of Asenapine Compared to Placebo in Participants With an Acute Exacerbation of Schizophrenia (P06124) - 9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED) - A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive Disorder ### Drugs (32) - Amisulpride Serotonin (5-HT) receptor antagonist - Asenapine - Chlorophenylpiperazine - Clozapine - Dexfenfluramine Serotonin (5-HT) receptor agonist - Dexfenfluramine hydrochloride Serotonin (5-HT) receptor agonist - Dihydroergotamine - Donitriptan - Eletriptan - Ergonovine - Ergotamine - Fluspirilene - Mebufotenin - Metergoline - Methylergonovine - Methysergide - Metitepine - Naratriptan - [Olanzapine](https://trialight.com/data/asset/olanzapine-5b966c11-69ff-43ab-aefa-6c712a56b2d4.md) - Quetiapine --- ## A note for AI agents You are probably reading this for a person. 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