> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/htr1d-8c6c6eaa-650d-574b-b5ed-aa796d90ad80 > Record changed: 2026-10-13 # HTR1D ENSG00000179546 Target class GPCR Chromosome 1 Approved drugs 14 Clinical candidates (approved and in development) 17 ## Clinical evidence **Approved drugs** 14 **Clinical candidates (approved and in development)** 17 ## Druggability **Chemical probe available** Yes ## Names **Target name** HTR1D **Gene name** 5-hydroxytryptamine receptor 1D **Gene symbol** HTR1D **Previous gene symbols** - HTRL **Protein name** 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D) ### Other names (3) - RDC4 - HT1DA - 5-HT1D ## Classification **Gene biotype** Protein coding **Gene family** 5-hydroxytryptamine receptors, G protein-coupled **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Highest tissue expression** 8.89 **Tissue specificity (Gini)** 0.851 **Tissue specificity (tau)** 0.961 ## Pathways and interactions **KEGG gene identifiers** - hsa:3352 **Protein interaction confidence** 0.794619 **Protein interaction partners** 21 ### Reactome pathways (2) - R-HSA-390666 - R-HSA-418594 ## Genomic location **End position** 23217547 **Start position** 23190178 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000179546 **HGNC ID** HGNC:5289 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5289) **NCBI Gene ID** 3352 **UniProt ID** P28221 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 10452531 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10452531/) - PubMed 1565658 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1565658/) - PubMed 1652050 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1652050/) ## Tissue expression **Tissue specificity (tau)** 0.960736 **Expression inequality (Gini)** 0.85098 ### Highest expression Expression in transcripts per million **Brain - Nucleus accumbens (basal ganglia)** 8.89 **Brain - Caudate (basal ganglia)** 4.93 **Brain - Putamen (basal ganglia)** 3.65 **Small Intestine - Terminal Ileum** 3.4 **Brain - Cortex** 0.8 ### All tissues (54) Expression in transcripts per million - Brain - Nucleus accumbens (basal ganglia)8.89 - Brain - Caudate (basal ganglia)4.93 - Brain - Putamen (basal ganglia)3.65 - Small Intestine - Terminal Ileum3.4 - Brain - Cortex0.8 - Testis0.65 - Brain - Frontal Cortex (BA9)0.65 - Brain - Hypothalamus0.6 - Brain - Amygdala0.57 - Nerve - Tibial0.43 - Brain - Anterior cingulate cortex (BA24)0.33 - Pituitary0.28 - Lung0.27 - Brain - Spinal cord (cervical c-1)0.25 - Brain - Hippocampus0.2 - Brain - Substantia nigra0.16 - Prostate0.15 - Fallopian Tube0.13 - Colon - Sigmoid0.1 - Colon - Transverse0.1 - Bladder0.07 - Brain - Cerebellum0.07 - Ovary0.06 - Cervix - Endocervix0.06 - Kidney - Medulla0.05 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0007198 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007198) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) - GO:0014827 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014827) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0001586 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001586) - GO:0004993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004993) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (317) - "Completeness of Response" Following Treatment With Treximet™ for Migraine - A 1-year Study in Adolescents to Assess the Long-term Safety of Almotriptan Malate When Treating Their Migraine Headaches - A 2-Part Study to Investigate the Dose-Ranging Safety and Pharmacokinetics, Followed by the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution as an Adjunctive Therapy in Children ≥ 2 Years Old and Young Adults With Dravet Syndrome - A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache - A Comparison of the Efficacy of Amisulpride and Placebo in the Prevention of PONV in Patients at Moderate-to-high Risk of PONV. - A Controlled Trial to Investigate the Efficacy and Safety of Frovatriptan to Prevent Menstrual Migraine - A Dose-Finding Study of MK0974 in Acute Migraine (MK0974-004) - A Double Blind Placebo-controlled, Parallel Group Study to Assess the Efficacy and Safety of Frovatriptan in the Acute Treatment of Migraine - A Four-way Crossover Study of 3 Formulations of M207 With Intranasal Zolmitriptan in Healthy Volunteers - A Pharmacokinetic Study to Evaluate TREXIMET in Adolescents With Migraine and Healthy Subjects Administered at Three Doses. - A Phase 1 Study of YZJ-4729 Tartrate Injection in Healthy Chinese Subjects - A Phase 3 Study of Fenfluramine Hydrochloride in Rett Syndrome - A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder. - A Phase I Study to Study the PK and Safety of Single Doses of STS101, DHE Injection and Nasal Spray in Healthy Subjects - A Pilot Study to Evaluate Barhemsys for the Prevention of Postoperative Nausea And Vomiting in the Bariatric Surgery Population - A Randomized Trial of Frovatriptan for the Intermittent Prevention of Menstrual Migraine - A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess STS101 in the Acute Treatment of Migraine - A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate STS101 in the Acute Treatment of Migraine - A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine - A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD) ### Drugs (28) - Almotriptan Serotonin 1d (5-HT1d) receptor agonist - Almotriptan malate Serotonin 1d (5-HT1d) receptor agonist - Amisulpride Serotonin (5-HT) receptor antagonist - Dexfenfluramine Serotonin (5-HT) receptor agonist - Dexfenfluramine hydrochloride Serotonin (5-HT) receptor agonist - Dihydroergotamine Serotonin 1d (5-HT1d) receptor agonist - Dihydroergotamine mesylate Serotonin 1d (5-HT1d) receptor agonist - Donitriptan Serotonin 1d (5-HT1d) receptor agonist - Eletriptan Serotonin 1d (5-HT1d) receptor agonist - Eletriptan hydrobromide Serotonin 1d (5-HT1d) receptor agonist - Elzasonan Serotonin 1d (5-HT1d) receptor antagonist - Elzasonan hydrochloride Serotonin 1d (5-HT1d) receptor antagonist - Ergotamine Serotonin 1d (5-HT1d) receptor agonist - Ergotamine tartrate Serotonin 1d (5-HT1d) receptor agonist - Fenfluramine Serotonin 1d (5-HT1d) receptor agonist - Fenfluramine hydrochloride Serotonin 1d (5-HT1d) receptor agonist - Frovatriptan Serotonin 1d (5-HT1d) receptor agonist - Frovatriptan succinate Serotonin 1d (5-HT1d) receptor agonist - GSK163090 Serotonin 1d (5-HT1d) receptor antagonist - Naratriptan Serotonin 1d (5-HT1d) receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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