> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/htr1b-f109dd33-597e-57af-8498-727af113b42b
> Record changed: 2026-10-13

# HTR1B

ENSG00000135312

Target class

GPCR

Chromosome

6

Approved drugs

12

Clinical candidates (approved and in development)

16

## Clinical evidence

**Approved drugs**

12

**Clinical candidates (approved and in development)**

16

## Druggability

**Chemical probe available**

No

## Names

**Target name**

HTR1B

**Gene name**

5-hydroxytryptamine receptor 1B

**Gene symbol**

HTR1B

**Protein name**

5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B)

### Other names (4)

- S12
- 5-HT1B
- HTR1D2
- 5-HT1DB

## Classification

**Gene biotype**

Protein coding

**Gene family**

5-hydroxytryptamine receptors, G protein-coupled

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

15

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

20.65

**Tissue specificity (Gini)**

0.747

**Tissue specificity (tau)**

0.942

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3351

**Protein interaction confidence**

0.793156

**Protein interaction partners**

32

### Reactome pathways (2)

- R-HSA-390666
- R-HSA-418594

## Genomic location

**End position**

77463491

**Start position**

77460924

**Chromosome**

6

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000135312

**HGNC ID**

HGNC:5287

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5287)

**NCBI Gene ID**

3351

**UniProt ID**

P28222

## Cellular location

- Cell membrane
- Multi-pass membrane protein .
- Endoplasmic reticulum
- Plasma membrane

### Publication evidence (10)

- PubMed 10452531  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10452531/)
- PubMed 1315531  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1315531/)
- PubMed 1328844  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1328844/)
- PubMed 1348246  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1348246/)
- PubMed 1351684  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1351684/)
- PubMed 1559993  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1559993/)
- PubMed 1565658  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1565658/)
- PubMed 1610347  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1610347/)
- PubMed 23519210  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23519210/)
- PubMed 23519215  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23519215/)

## Tissue expression

**Tissue specificity (tau)**

0.941816

**Expression inequality (Gini)**

0.74705

### Highest expression

Expression in transcripts per million

**Artery - Tibial**

20.65

**Artery - Aorta**

11.68

**Artery - Coronary**

11

**Cells - Cultured fibroblasts**

8.9

**Brain - Nucleus accumbens (basal ganglia)**

3.14

### All tissues (54)

Expression in transcripts per million

- Artery - Tibial20.65
- Artery - Aorta11.68
- Artery - Coronary11
- Cells - Cultured fibroblasts8.9
- Brain - Nucleus accumbens (basal ganglia)3.14
- Bladder2.41
- Esophagus - Muscularis2.33
- Esophagus - Gastroesophageal Junction2.06
- Testis1.79
- Brain - Caudate (basal ganglia)1.48
- Cervix - Ectocervix1.46
- Brain - Frontal Cortex (BA9)1.32
- Brain - Cortex1.31
- Brain - Putamen (basal ganglia)1.09
- Stomach1.04
- Adipose - Subcutaneous0.92
- Lung0.77
- Fallopian Tube0.76
- Brain - Anterior cingulate cortex (BA24)0.76
- Uterus0.76
- Nerve - Tibial0.68
- Brain - Hypothalamus0.66
- Kidney - Medulla0.62
- Cervix - Endocervix0.57
- Vagina0.55

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (7)

- GO:0007187  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187)
- GO:0007193  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193)
- GO:0007198  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007198)
- GO:0007268  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268)
- GO:0071312  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071312)
- GO:0071466  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071466)
- GO:1904707  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904707)

### Cellular components

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (3)

- GO:0001586  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001586)
- GO:0004993  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004993)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## On-target safety

- decreased anxiety  
### Effects (2)

  - Inhibition/Decrease/Downregulation: acute
  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased anxiety  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased memory  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased memory  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased memory  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased memory  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased aggression  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased aggression  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased body temperature  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased body temperature  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased aggression  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased aggression  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased eating  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased eating  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- cerebral and coronary artery vasoconstriction  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: cerebral and coronary artery vasoconstriction  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased aggression  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased aggression  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased blood pressure  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (273)

- "Completeness of Response" Following Treatment With Treximet™ for Migraine
- A 1-year Study in Adolescents to Assess the Long-term Safety of Almotriptan Malate When Treating Their Migraine Headaches
- A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache
- A Comparison of the Efficacy of Amisulpride and Placebo in the Prevention of PONV in Patients at Moderate-to-high Risk of PONV.
- A Controlled Trial to Investigate the Efficacy and Safety of Frovatriptan to Prevent Menstrual Migraine
- A Dose-Finding Study of MK0974 in Acute Migraine (MK0974-004)
- A Double Blind Placebo-controlled, Parallel Group Study to Assess the Efficacy and Safety of Frovatriptan in the Acute Treatment of Migraine
- A Four-way Crossover Study of 3 Formulations of M207 With Intranasal Zolmitriptan in Healthy Volunteers
- A Pharmacokinetic Study to Evaluate TREXIMET in Adolescents With Migraine and Healthy Subjects Administered at Three Doses.
- A Pilot Study to Evaluate Barhemsys for the Prevention of Postoperative Nausea And Vomiting in the Bariatric Surgery Population
- A Randomized Trial of Frovatriptan for the Intermittent Prevention of Menstrual Migraine
- A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)
- A Research Study To Evaluate If Frovatriptan Is Safe And Effective In Preventing Migraine Headache After Fasting
- A Study of 3 Dosage Strengths of Almotriptan Malate (AXERT®) in the Treatment of Acute Migraine in Adolescents
- A Study of ANAVEX3-71 in Adults With Schizophrenia
- A Study of HS-10353 in Adult Participants With Major Depressive Disorder
- A Study of Lasmiditan When Given With Sumatriptan in Healthy Participants
- A Study of M207 With Intranasal Zolmitriptan in Healthy Volunteers
- A Study of Rizatriptan Co-Administered With Acetaminophen for the Treatment of Acute Migraine
- A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis

### Drugs (25)

- Almotriptan Serotonin 1b (5-HT1b) receptor agonist
- Almotriptan malate Serotonin 1b (5-HT1b) receptor agonist
- Amisulpride Serotonin (5-HT) receptor antagonist
- Dexfenfluramine Serotonin (5-HT) receptor agonist
- Dexfenfluramine hydrochloride Serotonin (5-HT) receptor agonist
- Donitriptan Serotonin 1b (5-HT1b) receptor agonist
- Eletriptan Serotonin 1b (5-HT1b) receptor agonist
- Eletriptan hydrobromide Serotonin 1b (5-HT1b) receptor agonist
- Elzasonan Serotonin 1b (5-HT1b) receptor antagonist
- Elzasonan hydrochloride Serotonin 1b (5-HT1b) receptor antagonist
- Ergoloid Serotonin 1b (5-HT1b) receptor agonist
- Ergoloid mesylates Serotonin 1b (5-HT1b) receptor agonist
- Frovatriptan Serotonin 1b (5-HT1b) receptor agonist
- Frovatriptan succinate Serotonin 1b (5-HT1b) receptor agonist
- GSK163090 Serotonin 1b (5-HT1b) receptor antagonist
- Naratriptan Serotonin 1b (5-HT1b) receptor agonist
- Naratriptan hydrochloride Serotonin 1b (5-HT1b) receptor agonist
- [Rizatriptan](https://trialight.com/data/asset/rizatriptan-62bc4777-817b-40f6-b936-bbc1eba350d2.md) Serotonin 1b (5-HT1b) receptor agonist
- Rizatriptan benzoate Serotonin 1b (5-HT1b) receptor agonist
- Sumatriptan Serotonin 1b (5-HT1b) receptor agonist

---

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