> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/hrh2-5ddb02a6-bd6c-59a8-91de-1aa25ffc4091 > Record changed: 2026-10-13 # HRH2 ENSG00000113749 Target class GPCR Chromosome 5 Approved drugs 11 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 11 **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** Yes ## Names **Target name** HRH2 **Gene name** Histamine receptor H2 **Gene symbol** HRH2 **Protein name** Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) ## Classification **Gene biotype** Protein coding **Gene family** Histamine receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 45 **Highest tissue expression** 90.51 **Tissue specificity (Gini)** 0.634 **Tissue specificity (tau)** 0.947 ## Pathways and interactions **KEGG gene identifiers** - hsa:3274 **Protein interaction confidence** 0.845667 **Protein interaction partners** 6 ### Reactome pathways (2) - R-HSA-390650 - R-HSA-418555 ## Genomic location **End position** 175710756 **Start position** 175657797 **Chromosome** 5 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000113749 **HGNC ID** HGNC:5183 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5183) **NCBI Gene ID** 3274 **UniProt ID** P25021 ## Cellular location - Cell membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.947317 **Expression inequality (Gini)** 0.634074 ### Highest expression Expression in transcripts per million **Whole Blood** 90.51 **Spleen** 23.98 **Stomach** 18.85 **Brain - Caudate (basal ganglia)** 14.5 **Brain - Frontal Cortex (BA9)** 13.87 ### All tissues (54) Expression in transcripts per million - Whole Blood90.51 - Spleen23.98 - Stomach18.85 - Brain - Caudate (basal ganglia)14.5 - Brain - Frontal Cortex (BA9)13.87 - Brain - Cortex13.79 - Brain - Nucleus accumbens (basal ganglia)12.88 - Brain - Putamen (basal ganglia)12.07 - Heart - Left Ventricle11.88 - Lung10.21 - Artery - Coronary9.51 - Heart - Atrial Appendage7.45 - Adipose - Subcutaneous7.36 - Artery - Tibial7.17 - Brain - Anterior cingulate cortex (BA24)6.27 - Prostate5.95 - Adipose - Visceral (Omentum)5.87 - Fallopian Tube4.62 - Artery - Aorta4.53 - Nerve - Tibial4.15 - Breast - Mammary Tissue3.9 - Cervix - Ectocervix3.57 - Bladder3.42 - Uterus3.41 - Cervix - Endocervix3.12 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (2) - GO:0004969 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004969) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## On-target safety - increased heart rate ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased heart rate ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased eating ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased eating ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Increased, predation ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/99) - positive inotropic effect on the human ventricle ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: positive inotropic effect on the human ventricle ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - reduction of gastric acid secretion ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: reduction of gastric acid secretion ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased gastric acid secretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased gastric acid secretion ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased gastric emptying ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased gastric emptying ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased inflammation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased inflammation ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased drinking ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased drinking ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Decreased, survival ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/99) - decreased blood pressure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased gastric acid secretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased gastric acid secretion ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - inflammation ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: inflammation ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - emesis ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: emesis ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - stimulation of gastric acid secretion ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: stimulation of gastric acid secretion ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased gastric emptying ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased gastric emptying ### Biological samples (3) - immune - cardiovascular - gastrointestinal PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Off-target safety - decreased gastric acid secretion ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased gastric acid secretion ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - positive inotropy ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: positive inotropy ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased gastric acid secretion ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased gastric acid secretion ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - emesis ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: emesis ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (204) - : Vascular Function in Health and Disease - \[KJ-INT-002\] BE Study - A Clinico-Bacteriological Study and Effect of Stress Ulcer Prophylaxis on Occurrence of Ventilator Associated Pneumonia - A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued - A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only - A Comparison of Efficacy of Intravenous Esomeprazole and Ranitidine Treatment of Dyspeptic Pain - A Crossover Study to Assess the Drug-drug Interaction of Acid Reducing Agent(s) on the Pharmacokinetics of a Single Oral Dose of Lumicitabine (JNJ-64041575) in Healthy Adult Participants - A Multi-center, Randomized, Double-blind Phase III Clinical Trial to Assess and Compare to the Efficacy and Safety of Lafutidine, Famotidine and Omeprazole-referenced in Korean Erosive Esophagitis Patients - A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986263 in Healthy Participants - A Phase 1 Study to Evaluate the Effects of Omeprazole and Famotidine on the Absorption of Telotristat Ethyl in Healthy Subjects - A Phase 2 Study of Isatuximab in Combination With Pomalidomide and Dexamethasone in MM Patients Who Received One Prior Line of Therapy Containing Lenalidomide and a Proteasome Inhibitor - A Phase I Study of Oral Ixabepilone in Subjects With Advanced Cancer - A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal Adenocarcinoma - A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology - A Phase II Trial of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With Chemoradiation - A Pilot Randomized, Double-Blind, Placebo-Controlled, Parallel Design, Multicenter Trial to Evaluate the Effect of Ranitidine on Immunologic Indicators in Asymptomatic HIV-1 Infected Subjects With a CD4 Cell Count Between 400-700 Cells/mm3 - A Relative Bioavailability Study of 20 mg Famotidine Tablets Under Fasting Condition - A Relative Bioavailability Study of 20 mg Famotidine Tablets Under Fed Condition - [A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers](https://trialight.com/data/trial/a-single-and-multiple-ascending-doses-relative-e765be29-f034-4382-84c2-075c49a7d226.md) - A Study Assessing the Drug Levels, Drug Effects, and Safety of BMS-986322 in Healthy Participants ### Drugs (15) - Betazole Histamine H2 receptor agonist - Betazole hydrochloride Histamine H2 receptor agonist - Cimetidine Histamine H2 receptor antagonist - Cimetidine hydrochloride Histamine H2 receptor antagonist - Ebrotidine Histamine H2 receptor antagonist - [Famotidine](https://trialight.com/data/asset/famotidine-5721dbb9-1373-4622-a660-e27ebf480acc.md) Histamine H2 receptor antagonist - Lafutidine Histamine H2 receptor antagonist - Methantheline Histamine H2 receptor antagonist - Methantheline bromide Histamine H2 receptor antagonist - Nizatidine Histamine H2 receptor antagonist - Ranitidine Histamine H2 receptor antagonist - Ranitidine bismuth citrate Histamine H2 receptor antagonist - Ranitidine hydrochloride Histamine H2 receptor antagonist - Tolazoline Histamine H2 receptor agonist - Tolazoline hydrochloride Histamine H2 receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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