> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/hmgcr-fb72eea1-5506-5785-8e3a-288028d487d6 > Record changed: 2026-10-13 # HMGCR ENSG00000113161 Target class Enzyme Chromosome 5 Approved drugs 10 Clinical candidates (approved and in development) 10 ## Clinical evidence **Approved drugs** 10 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 10 ## Druggability **Chemical probe available** Yes ## Names **Target name** HMGCR **Gene name** 3-hydroxy-3-methylglutaryl-CoA reductase **Gene symbol** HMGCR **Protein name** 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) ## Classification **Gene biotype** Protein coding **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 80.4 **Tissue specificity (Gini)** 0.393 **Tissue specificity (tau)** 0.771 ## Pathways and interactions **KEGG gene identifiers** - hsa:3156 **Reactome pathways** - R-HSA-9619665 **Protein interaction confidence** 0.8547 **Protein interaction partners** 70 ## Genomic location **End position** 75364241 **Start position** 75336329 **Chromosome** 5 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000113161 **HGNC ID** HGNC:5006 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:5006) **NCBI Gene ID** 3156 **UniProt ID** P04035 ## Cellular location - Endoplasmic reticulum membrane - Multi-pass membrane protein . Peroxisome membrane - Multi-pass membrane protein . ### Publication evidence (2) - PubMed 17180682 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17180682/) - PubMed 2991281 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2991281/) ## Tissue expression **Tissue specificity (tau)** 0.770823 **Expression inequality (Gini)** 0.392831 ### Highest expression Expression in transcripts per million **Skin - Not Sun Exposed (Suprapubic)** 80.4 **Skin - Sun Exposed (Lower leg)** 73.77 **Cells - EBV-transformed lymphocytes** 66.15 **Esophagus - Mucosa** 63.81 **Vagina** 42.86 ### All tissues (54) Expression in transcripts per million - Skin - Not Sun Exposed (Suprapubic)80.4 - Skin - Sun Exposed (Lower leg)73.77 - Cells - EBV-transformed lymphocytes66.15 - Esophagus - Mucosa63.81 - Vagina42.86 - Adrenal Gland42.44 - Brain - Cerebellar Hemisphere31.92 - Brain - Frontal Cortex (BA9)28.76 - Testis26.34 - Brain - Cerebellum26.17 - Cells - Cultured fibroblasts25.65 - Colon - Transverse23.38 - Lung22.73 - Nerve - Tibial20.24 - Thyroid20.17 - Small Intestine - Terminal Ileum20.05 - Brain - Spinal cord (cervical c-1)19.86 - Brain - Cortex19.83 - Brain - Hypothalamus19.62 - Brain - Anterior cingulate cortex (BA24)17.41 - Cervix - Endocervix16.33 - Spleen16.05 - Minor Salivary Gland15.77 - Brain - Nucleus accumbens (basal ganglia)15.68 - Pituitary15.07 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0006695 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006695) ### Cellular components (3) - GO:0005778 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005778) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) ### Molecular functions (4) - GO:0004420 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004420) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0070402 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070402) - GO:0120225 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120225) ## On-target safety - Decrease, Fertility ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/124) ## Related records ### Trials (2,299) - "Efficacy Of 1.2% Rosuvastatin Gel In The Management Of Infrabony Defects" - \[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers\] - 1.2% Atorvastatin and 1.2% Simvastatin in Treatment of Chronic Periodontitis - 1.2% Rosuvastatin Gel As A Local Agent In Smokers With Chronic Periodontitis - 1.2% Rosuvastatin Subgingivally Delivered In Chronic Periodontitis With Type 2 Diabetes Mellitus - 12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe - 15-Day Repeated-Dose Study With SB-649868 And Its Interaction With CYP3A4 Isoenzyme In Healthy Male Subjects. - 30 Week Study of the Combination of ABT-335 and Rosuvastatin Compared to Rosuvastatin Monotherapy for Subjects With Dyslipidemia and Stage 3 Chronic Kidney Disease - 3Mixtatin Versus Modified 3Mix-MP in Lesion Sterilization and Tissue Repair for Treatment of Necrotic Primary Molars - 48-wk Open Label Phase IIIb to Evaluate Efficacy and Safety - 7 Tesla MRI Study in Patients With Statin Related Muscle Complaints - 7-day Atorvastatin and Emotional Processing - 7-day Simvastatin and Emotional Processing - 7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events - 8-Week PK/PD Atorvastatin Study In Children And Adolescents With Heterozygous Familial Hypercholesterolemia - A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and Hypercholesterolemia - A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808) - A 12-Week Study Comparing Pitavastatin 4 mg vs. Pravastatin 40 mg in HIV-Infected Subjects - A 12-week Study to Compare the Efficacy and Safety of Fixed Combinations of Fenofibrate/Simvastatin 145/20mg and Fenofibrate/Simvastatin 145/40mg Tablets Versus Fenofibrate or Simvastatin Monotherapies in Subjects With Abnormal Blood Levels of Fats (Lipids) and at High Risk of Cardiovascular Disease - A 16 Week Comparative Study of Fenofibrate Versus Ezetimibe as Add-on Therapy to Atorvastatin ### Drugs (16) - Atorvastatin HMG-CoA reductase inhibitor - Atorvastatin calcium HMG-CoA reductase inhibitor - Cerivastatin HMG-CoA reductase inhibitor - Cerivastatin sodium HMG-CoA reductase inhibitor - Fluvastatin HMG-CoA reductase inhibitor - Fluvastatin sodium HMG-CoA reductase inhibitor - Lovastatin HMG-CoA reductase inhibitor - Pitavastatin HMG-CoA reductase inhibitor - Pitavastatin calcium HMG-CoA reductase inhibitor - Pitavastatin magnesium HMG-CoA reductase inhibitor - Pitavastatin sodium HMG-CoA reductase inhibitor - Pravastatin HMG-CoA reductase inhibitor - Pravastatin sodium HMG-CoA reductase inhibitor - [Rosuvastatin](https://trialight.com/data/asset/rosuvastatin-d8e48bc8-dc4d-4234-8b99-9b05b70b7a69.md) HMG-CoA reductase inhibitor - Rosuvastatin calcium HMG-CoA reductase inhibitor - Simvastatin HMG-CoA reductase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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