> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/hdac6-f8858cdc-1d66-56fc-a7ca-f6200b56296a
> Record changed: 2026-10-13

# HDAC6

ENSG00000094631

Target class

Epigenetic regulator

Chromosome

X

Approved drugs

5

Clinical candidates (approved and in development)

12

## Clinical evidence

**Approved drugs**

5

**Clinical candidates (approved and in development)**

12

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

HDAC6

**Gene name**

Histone deacetylase 6

**Gene symbol**

HDAC6

**Protein name**

Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)

### Other names (6)

- KIAA0901
- JM21
- HD6
- FLJ16239
- PPP1R90
- KDAC6

## Classification

**Gene biotype**

Protein coding

**Gene family**

Ring finger proteins|Protein phosphatase 1 regulatory subunits|Histone deacetylases, class IIB

**Target class**

Epigenetic regulator

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

105.27

**Tissue specificity (Gini)**

0.3

**Tissue specificity (tau)**

0.622

## Pathways and interactions

**KEGG gene identifiers**

- hsa:10013

**Protein interaction confidence**

0.8106

**Protein interaction partners**

100

### Reactome pathways (12)

- R-HSA-2122947
- R-HSA-2644606
- R-HSA-2894862
- R-HSA-3371511
- R-HSA-350054
- R-HSA-5620920
- R-HSA-8878166
- R-HSA-8940973
- R-HSA-9613829
- R-HSA-9615710
- R-HSA-9646399
- R-HSA-9976102

## Genomic location

**End position**

48824986

**Start position**

48801377

**Chromosome**

X

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000094631

**HGNC ID**

HGNC:14064

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:14064)

**NCBI Gene ID**

10013

**UniProt ID**

Q9UBN7

## Cellular location

- Cytoplasm . Cytoplasm, cytoskeleton . Nucleus . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cell projection, cilium . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body . Note=Mainly cytoplasmic where it is associated with microtubules (PubMed:12024216). Can shuttle between the cytoplasm and the nucleus (PubMed:39567688). Retained in the cytoplasm by binding to valine via the primate-specific SE14 repeat region while valine deprivation induces nuclear localization (PubMed:39567688). Found exclusively in the cytoplasm in proliferative cells with a fraction found in the nucleus during differentiation (By similarity). May translocate to the nucleus following DNA damage (PubMed:30770470). .
- Basal body
- Centrosome
- Cytosol

### Publication evidence (8)

- PubMed 12024216  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12024216/)
- PubMed 24687993  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24687993/)
- PubMed 26246421  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26246421/)
- PubMed 30770470  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30770470/)
- PubMed 39567688  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/39567688/)
- PubMed 24882211  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24882211/)
- PubMed 26080397  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26080397/)
- PubMed 17604723  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17604723/)

## Tissue expression

**Tissue specificity (tau)**

0.622493

**Expression inequality (Gini)**

0.299551

### Highest expression

Expression in transcripts per million

**Pituitary**

105.27

**Testis**

93.66

**Brain - Cerebellum**

91.96

**Brain - Cerebellar Hemisphere**

84

**Uterus**

80.54

### All tissues (54)

Expression in transcripts per million

- Pituitary105.27
- Testis93.66
- Brain - Cerebellum91.96
- Brain - Cerebellar Hemisphere84
- Uterus80.54
- Ovary80.1
- Cervix - Ectocervix70.69
- Cervix - Endocervix70.23
- Thyroid68.98
- Fallopian Tube66.78
- Nerve - Tibial62.08
- Prostate51.93
- Lung49.62
- Vagina49.06
- Colon - Sigmoid46.75
- Spleen46.58
- Artery - Aorta45.44
- Liver45.29
- Bladder43.8
- Esophagus - Gastroesophageal Junction43.69
- Esophagus - Muscularis41.25
- Kidney - Cortex40.47
- Small Intestine - Terminal Ileum40.07
- Artery - Tibial39.08
- Artery - Coronary38.48

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (33)

- GO:0006476  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006476)
- GO:0006515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006515)
- GO:0006886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006886)
- GO:0007173  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007173)
- GO:0010506  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010506)
- GO:0010634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010634)
- GO:0010727  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010727)
- GO:0016241  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016241)
- GO:0019896  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019896)
- GO:0031333  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031333)
- GO:0031647  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031647)
- GO:0032418  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032418)
- GO:0032461  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032461)
- GO:0033148  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033148)
- GO:0034605  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034605)
- GO:0035967  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035967)
- GO:0043242  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043242)
- GO:0045814  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045814)
- GO:0045861  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045861)
- GO:0051788  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051788)
- GO:0060271  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060271)
- GO:0060632  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060632)
- GO:0060765  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060765)
- GO:0061523  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061523)
- GO:0061734  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061734)

And 8 more, listed on the interactive page.

### Cellular components (14)

- GO:0000118  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000118)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005771  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005771)
- GO:0005813  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005813)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005874  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005874)
- GO:0005875  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005875)
- GO:0005901  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901)
- GO:0016234  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016234)
- GO:0016235  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016235)
- GO:0031252  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031252)
- GO:0036064  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036064)
- GO:0048471  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471)

### Molecular functions (20)

- GO:0000978  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000978)
- GO:0001222  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001222)
- GO:0004407  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004407)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008013  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008013)
- GO:0008017  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008017)
- GO:0019899  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899)
- GO:0031593  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031593)
- GO:0031625  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625)
- GO:0033558  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033558)
- GO:0036479  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036479)
- GO:0042030  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042030)
- GO:0042826  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042826)
- GO:0042903  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042903)
- GO:0043014  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043014)
- GO:0047611  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047611)
- GO:0048156  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048156)
- GO:0051787  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051787)
- GO:0051879  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051879)
- GO:0070840  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070840)

## Off-target safety

- regulation of catalytic activity  
### Studies (2)

  - biochemical: NVS\_ENZ\_hHDAC6, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hHDAC6 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.
  - biochemical: NVS\_ENZ\_hHDAC6, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hHDAC6 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (795)

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- A Panobinostat Presurgery

### Drugs (14)

- Abexinostat Histone deacetylase inhibitor
- Belinostat Histone deacetylase inhibitor
- CUDC-101 Histone deacetylase inhibitor
- Entinostat Histone deacetylase inhibitor
- Fimepinostat Histone deacetylase inhibitor
- Givinostat Histone deacetylase inhibitor
- Givinostat hydrochloride Histone deacetylase inhibitor
- Panobinostat Histone deacetylase inhibitor
- Panobinostat lactate Histone deacetylase inhibitor
- Quisinostat Histone deacetylase inhibitor
- Ricolinostat Histone deacetylase 6 inhibitor
- Romidepsin Histone deacetylase inhibitor
- Tacedinaline Histone deacetylase inhibitor
- [Vorinostat](https://trialight.com/data/asset/vorinostat-ae074418-90c3-4664-ba21-68c35e010c8f.md) Histone deacetylase 6 inhibitor

---

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