> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/hdac3-721f32e6-013c-5e40-8462-89edf8cff8ba > Record changed: 2026-10-13 # HDAC3 ENSG00000171720 Target class Epigenetic regulator Chromosome 5 Approved drugs 5 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** Yes ## Names **Target name** HDAC3 **Gene name** Histone deacetylase 3 **Gene symbol** HDAC3 **Protein name** Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45) ### Other names (4) - RPD3 - HD3 - RPD3-2 - KDAC3 ## Classification **Gene biotype** Protein coding **Gene family** Histone deacetylases, class I|NCoR/SMRT transcriptional repression complex subunits **Target class** Epigenetic regulator **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 114.92 **Tissue specificity (Gini)** 0.25 **Tissue specificity (tau)** 0.545 ## Pathways and interactions **KEGG gene identifiers** - hsa:8841 **Protein interaction confidence** 0.819875 **Protein interaction partners** 112 ### Reactome pathways (25) - R-HSA-193670 - R-HSA-1989781 - R-HSA-2122947 - R-HSA-2151201 - R-HSA-2644606 - R-HSA-2894862 - R-HSA-3214815 - R-HSA-350054 - R-HSA-381340 - R-HSA-390471 - R-HSA-400206 - R-HSA-5617472 - R-HSA-8940973 - R-HSA-8943724 - R-HSA-9022537 - R-HSA-9022692 - R-HSA-9029569 - R-HSA-9609690 - R-HSA-9701898 - R-HSA-9707564 - R-HSA-9707616 - R-HSA-9841922 - R-HSA-9931509 - R-HSA-9933387 - R-HSA-9976102 ## Genomic location **End position** 141636867 **Start position** 141620778 **Chromosome** 5 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000171720 **HGNC ID** HGNC:4854 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4854) **NCBI Gene ID** 8841 **UniProt ID** O15379 ## Cellular location - Nucleus . Chromosome . Cytoplasm . Cytoplasm, cytosol . Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). . - Cytosol - Golgi apparatus - Nucleoplasm ### Publication evidence (4) - PubMed 21030595 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21030595/) - PubMed 16569215 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16569215/) - PubMed 18417529 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18417529/) - PubMed 25190803 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25190803/) ## Tissue expression **Tissue specificity (tau)** 0.544993 **Expression inequality (Gini)** 0.249796 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 114.92 **Skin - Sun Exposed (Lower leg)** 86.95 **Cervix - Endocervix** 83.59 **Cells - Cultured fibroblasts** 83.28 **Ovary** 82.51 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes114.92 - Skin - Sun Exposed (Lower leg)86.95 - Cervix - Endocervix83.59 - Cells - Cultured fibroblasts83.28 - Ovary82.51 - Uterus81.06 - Skin - Not Sun Exposed (Suprapubic)79.92 - Brain - Cerebellar Hemisphere79.23 - Cervix - Ectocervix78.97 - Brain - Cerebellum78.9 - Thyroid77.47 - Adrenal Gland77.43 - Spleen77.14 - Fallopian Tube72.94 - Vagina72.51 - Nerve - Tibial70.35 - Pituitary68.61 - Bladder66.85 - Prostate66.02 - Esophagus - Mucosa65.23 - Artery - Aorta62.33 - Artery - Tibial60.3 - Esophagus - Gastroesophageal Junction59.16 - Colon - Sigmoid58.43 - Lung58.34 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (18) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0000132 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000132) - GO:0001934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001934) - GO:0006325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006325) - GO:0006476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006476) - GO:0010832 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010832) - GO:0031647 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031647) - GO:0032008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032008) - GO:0042307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042307) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0045892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045892) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0046329 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046329) - GO:0051225 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051225) - GO:0060633 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060633) - GO:0071498 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071498) - GO:0140861 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140861) - GO:0160020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160020) ### Cellular components (8) - GO:0000118 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000118) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005694) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0017053 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017053) - GO:0072686 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072686) ### Molecular functions (17) - GO:0001222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001222) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0003714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003714) - GO:0004407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004407) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0030332 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030332) - GO:0033558 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033558) - GO:0042826 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042826) - GO:0051059 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051059) - GO:0140229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140229) - GO:0140297 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140297) - GO:0141221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141221) - GO:0160008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160008) - GO:0160009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160009) - GO:0160010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160010) - GO:0160216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160216) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hHDAC3, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hHDAC3 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (805) - 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat - A Clinical Study Evaluating the Efficacy and Safety of CMS-D001 Tablets in the Treatment of Adult Patients With Moderate to Severe Plaque-type Psoriasis - A Clinical Study on Prophylactic RespOnse To hEtrombopag for Secondary Prevention in Anti-Cancer Therapy-induced Thrombocytopeniae - A Clinical Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Abexinostat in Chinese Patients - A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Adenocarcinoma - A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Advanced Multiple Myeloma (0683-004) - A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Relapsed or Refractory Breast, Colorectal and Non-Small Cell Lung Cancer (0683-011)(TERMINATED) - A Clinical Trial of Vorinostat (MK0683, SAHA) in Combination With FDA Approved Cancer Drugs in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)(0683-056) - A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract Cancer - A Continuation Clinical Trial of Oral Vorinostat (MK-0683) in Advanced Cancers (MK-0683-007) - A Crossover Study to Assess the Effects of Vorinostat (MK0683, SAHA) in Patients With Advanced Cancer (0683-070)(COMPLETED) - A Disease Registry Encompassing the Care Of Patients With Multiple Myeloma on Panobinostat - A Dose Finding Study With I.V. Panobinostat (LBH589), Docetaxel, and Prednisone in Patients With Hormone Refractory Prostate Cancer - A Dose Ranging Placebo-controlled Double-blind Study to Evaluate the Safety, Pharmacokinetics and Efficacy of 610 in Participants With Severe Eosinophilic Asthma - A First Time in Human Study to Assess GSK2336805 in Healthy Volunteers and Single Doses in Chronically Infected Hepatitis C Patients. - A Japanese Phase 1/2 Study to Assess the Efficacy, Safety and Pharmacokinetics of Romidepsin in Patients With Peripheral T-cell Lymphoma (PTCL) - A Multi-Center Phase 2 Study to Evaluate Efficacy and Safety of Oral Abexinostat as Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma - A Multicenter, Open-Label Continuation Trial Evaluating the Tolerability and Activity of Depsipeptide (FK228) in Patients That Have Completed a Prior Clinical Study With Depsipeptide. - A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase Ⅱ Clinical Study to Evaluate the Efficacy and Safety of CMS-D001 in Adult Patients With Moderate to Severe Atopic Dermatitis - A Panobinostat Presurgery ### Drugs (14) - Abexinostat Histone deacetylase inhibitor - Belinostat Histone deacetylase inhibitor - CUDC-101 Histone deacetylase inhibitor - Entinostat Histone deacetylase inhibitor - Fimepinostat Histone deacetylase inhibitor - Givinostat Histone deacetylase inhibitor - Givinostat hydrochloride Histone deacetylase inhibitor - Mocetinostat Histone deacetylase 3 inhibitor - Panobinostat Histone deacetylase inhibitor - Panobinostat lactate Histone deacetylase inhibitor - Quisinostat Histone deacetylase inhibitor - Romidepsin Histone deacetylase inhibitor - Tacedinaline Histone deacetylase inhibitor - [Vorinostat](https://trialight.com/data/asset/vorinostat-ae074418-90c3-4664-ba21-68c35e010c8f.md) Histone deacetylase 3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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