> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/hdac1-8fadff30-6e38-5bb8-b71d-354606572141 > Record changed: 2026-10-13 # HDAC1 ENSG00000116478 Target class Epigenetic regulator Chromosome 1 Approved drugs 5 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 5 **ClinGen gene-disease validity** Disputed **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** Yes ## Names **Target name** HDAC1 **Gene name** Histone deacetylase 1 **Gene symbol** HDAC1 **Previous gene symbols** - RPD3L1 **Protein name** Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) ### Other names (3) - HD1 - GON-10 - KDAC1 ## Classification **Gene biotype** Protein coding **Gene family** Histone deacetylases, class I|EMSY complex|NuRD complex subunits|SIN3 histone deacetylase complex subunits|CoREST complex subunits|MiDAC complex subunits|MIER complex subunits|RERE complex subunits **Target class** Epigenetic regulator **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 226.13 **Tissue specificity (Gini)** 0.36 **Tissue specificity (tau)** 0.709 ## Pathways and interactions **KEGG gene identifiers** - hsa:3065 **Protein interaction confidence** 0.879674 **Protein interaction partners** 334 ### Reactome pathways (42) - R-HSA-1362277 - R-HSA-1362300 - R-HSA-1538133 - R-HSA-193670 - R-HSA-201722 - R-HSA-2122947 - R-HSA-2173795 - R-HSA-2173796 - R-HSA-2644606 - R-HSA-2894862 - R-HSA-3214815 - R-HSA-350054 - R-HSA-3769402 - R-HSA-427389 - R-HSA-427413 - R-HSA-4551638 - R-HSA-4641265 - R-HSA-6804758 - R-HSA-69205 - R-HSA-73762 - R-HSA-8936459 - R-HSA-8943724 - R-HSA-9018519 - R-HSA-9022538 - R-HSA-9022692 And 17 more, listed on the interactive page. ## Genomic location **End position** 32333635 **Start position** 32291921 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000116478 **HGNC ID** HGNC:4852 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4852) **NCBI Gene ID** 3065 **UniProt ID** Q13547 ## Cellular location - Nucleus . - Nucleoplasm ### Publication evidence (4) - PubMed 10846170 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10846170/) - PubMed 20523938 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20523938/) - PubMed 28977666 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28977666/) - PubMed 33283408 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33283408/) ## Tissue expression **Tissue specificity (tau)** 0.708675 **Expression inequality (Gini)** 0.359999 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 226.13 **Thyroid** 134.58 **Ovary** 129.75 **Spleen** 125.83 **Small Intestine - Terminal Ileum** 124.06 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes226.13 - Thyroid134.58 - Ovary129.75 - Spleen125.83 - Small Intestine - Terminal Ileum124.06 - Esophagus - Mucosa123.01 - Cervix - Endocervix122.35 - Cervix - Ectocervix121.46 - Vagina120.16 - Uterus118.22 - Colon - Transverse117.5 - Prostate108.45 - Fallopian Tube103.92 - Cells - Cultured fibroblasts103.02 - Pituitary97.84 - Bladder93.58 - Lung88.05 - Colon - Sigmoid87.58 - Testis85.28 - Minor Salivary Gland83.24 - Stomach77.55 - Esophagus - Gastroesophageal Junction77.28 - Nerve - Tibial76.35 - Artery - Tibial76.12 - Esophagus - Muscularis74.26 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (17) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0006325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006325) - GO:0006338 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006338) - GO:0006346 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006346) - GO:0006357 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006357) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0010629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629) - GO:0010832 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010832) - GO:0033148 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033148) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0043922 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043922) - GO:0045814 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045814) - GO:0045892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045892) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0060766 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060766) - GO:0090090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090090) ### Cellular components (9) - GO:0000118 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000118) - GO:0000785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000785) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0016581 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016581) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0070822 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070822) ### Molecular functions (19) - GO:0000978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000978) - GO:0000979 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000979) - GO:0001046 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001046) - GO:0001222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001222) - GO:0002039 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002039) - GO:0003714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003714) - GO:0004407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004407) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0031492 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031492) - GO:0033558 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033558) - GO:0042826 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042826) - GO:0051059 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051059) - GO:0061629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061629) - GO:0140297 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140297) - GO:0141221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141221) - GO:0160008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160008) - GO:0160009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160009) - GO:0160216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160216) ## On-target safety - Neural tube defects ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based ### Biological samples - organ Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/275) - Neural tube defects ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based ### Biological samples - organ Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/449) - Facial cartilage structures are reduced in size and morphologically distorted ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based ### Biological samples - organ Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/274) - Testicular atrophy ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based ### Biological samples - organ Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/212) ## Off-target safety - regulation of transcription factor activity ### Studies - cell-based: TOX21\_HDAC\_Inhibition is one of one assay component(s) measured or calculated from the TOX21\_HDAC\_Inhibition assay. It is designed to make measurements of HDAC activity as detected with bioluminescence signals by luciferase-coupled ATP quantitation technology. ### Biological samples - HCT-116, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (805) - 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat - A Clinical Study Evaluating the Efficacy and Safety of CMS-D001 Tablets in the Treatment of Adult Patients With Moderate to Severe Plaque-type Psoriasis - A Clinical Study on Prophylactic RespOnse To hEtrombopag for Secondary Prevention in Anti-Cancer Therapy-induced Thrombocytopeniae - A Clinical Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Abexinostat in Chinese Patients - A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Adenocarcinoma - A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Advanced Multiple Myeloma (0683-004) - A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Relapsed or Refractory Breast, Colorectal and Non-Small Cell Lung Cancer (0683-011)(TERMINATED) - A Clinical Trial of Vorinostat (MK0683, SAHA) in Combination With FDA Approved Cancer Drugs in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)(0683-056) - A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract Cancer - A Continuation Clinical Trial of Oral Vorinostat (MK-0683) in Advanced Cancers (MK-0683-007) - A Crossover Study to Assess the Effects of Vorinostat (MK0683, SAHA) in Patients With Advanced Cancer (0683-070)(COMPLETED) - A Disease Registry Encompassing the Care Of Patients With Multiple Myeloma on Panobinostat - A Dose Finding Study With I.V. Panobinostat (LBH589), Docetaxel, and Prednisone in Patients With Hormone Refractory Prostate Cancer - A Dose Ranging Placebo-controlled Double-blind Study to Evaluate the Safety, Pharmacokinetics and Efficacy of 610 in Participants With Severe Eosinophilic Asthma - A First Time in Human Study to Assess GSK2336805 in Healthy Volunteers and Single Doses in Chronically Infected Hepatitis C Patients. - A Japanese Phase 1/2 Study to Assess the Efficacy, Safety and Pharmacokinetics of Romidepsin in Patients With Peripheral T-cell Lymphoma (PTCL) - A Multi-Center Phase 2 Study to Evaluate Efficacy and Safety of Oral Abexinostat as Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma - A Multicenter, Open-Label Continuation Trial Evaluating the Tolerability and Activity of Depsipeptide (FK228) in Patients That Have Completed a Prior Clinical Study With Depsipeptide. - A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase Ⅱ Clinical Study to Evaluate the Efficacy and Safety of CMS-D001 in Adult Patients With Moderate to Severe Atopic Dermatitis - A Panobinostat Presurgery ### Drugs (14) - Abexinostat Histone deacetylase inhibitor - Belinostat Histone deacetylase inhibitor - CUDC-101 Histone deacetylase inhibitor - Entinostat Histone deacetylase inhibitor - Fimepinostat Histone deacetylase inhibitor - Givinostat Histone deacetylase inhibitor - Givinostat hydrochloride Histone deacetylase inhibitor - Mocetinostat Histone deacetylase 1 inhibitor - Panobinostat Histone deacetylase inhibitor - Panobinostat lactate Histone deacetylase inhibitor - Quisinostat Histone deacetylase inhibitor - Romidepsin Histone deacetylase inhibitor - Tacedinaline Histone deacetylase inhibitor - [Vorinostat](https://trialight.com/data/asset/vorinostat-ae074418-90c3-4664-ba21-68c35e010c8f.md) Histone deacetylase 1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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