> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/hcrtr1-fe2b8b6d-e646-5d68-8fcc-5f3c29444e6b > Record changed: 2026-10-13 # HCRTR1 ENSG00000121764 Target class GPCR Chromosome 1 Approved drugs 4 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** Yes ## Names **Target name** HCRTR1 **Gene name** Hypocretin receptor 1 **Gene symbol** HCRTR1 **Protein name** Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R) ### Other names (3) - OX1R - OXR1 - ORXR1 ## Classification **Gene biotype** Protein coding **Gene family** Hypocretin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 1.32 **Tissue specificity (Gini)** 0.571 **Tissue specificity (tau)** 0.847 ## Pathways and interactions **KEGG gene identifiers** - hsa:3061 **Protein interaction confidence** 0.799571 **Protein interaction partners** 7 ### Reactome pathways (2) - R-HSA-389397 - R-HSA-416476 ## Genomic location **End position** 31632518 **Start position** 31617660 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000121764 **HGNC ID** HGNC:4848 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4848) **NCBI Gene ID** 3061 **UniProt ID** O43613 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (2) - PubMed 26950369 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26950369/) - PubMed 9491897 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9491897/) ## Tissue expression **Tissue specificity (tau)** 0.846913 **Expression inequality (Gini)** 0.570534 ### Highest expression Expression in transcripts per million **Thyroid** 1.32 **Kidney - Medulla** 1.05 **Brain - Hypothalamus** 0.98 **Pituitary** 0.95 **Esophagus - Muscularis** 0.63 ### All tissues (54) Expression in transcripts per million - Thyroid1.32 - Kidney - Medulla1.05 - Brain - Hypothalamus0.98 - Pituitary0.95 - Esophagus - Muscularis0.63 - Artery - Aorta0.52 - Breast - Mammary Tissue0.44 - Esophagus - Gastroesophageal Junction0.43 - Adipose - Visceral (Omentum)0.42 - Brain - Cortex0.41 - Adipose - Subcutaneous0.4 - Artery - Coronary0.32 - Brain - Frontal Cortex (BA9)0.3 - Heart - Left Ventricle0.24 - Testis0.21 - Artery - Tibial0.21 - Muscle - Skeletal0.2 - Brain - Anterior cingulate cortex (BA24)0.18 - Fallopian Tube0.18 - Brain - Cerebellum0.17 - Brain - Substantia nigra0.16 - Colon - Sigmoid0.15 - Brain - Cerebellar Hemisphere0.14 - Uterus0.14 - Brain - Hippocampus0.14 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0007218 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007218) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) - GO:0007631 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007631) - GO:0051480 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051480) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016499 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016499) ## Related records ### Trials (203) - 15-Day Repeated-Dose Study With SB-649868 And Its Interaction With CYP3A4 Isoenzyme In Healthy Male Subjects. - 2-Part Multiple Ascending Dose Study for Safety and Pharmacokinetics in Healthy and Elderly Subjects - A 2-Part Single Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2006 - A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion - A Clinical Pharmacology Study of TS-142 in Patients with Obstructive Sleep Apnea Hypopnea. - A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects - A Clinical Study to Evaluate the Pharmacokinetic Profile of SB-649868 in Elderly and Female Population - A Clinical Study to Investigate the Food Effect on the Pharmacokinetics of ACT-541468 in Healthy Male Subjects - A Clinical Study to Investigate the Potential Interactions Between Food and ACT-541468 and Between ACT-541468 and Midazolam - A Comparison of the Physiological and Behavioral Effects of Suvorexant and Zolpidem in Healthy Volunteers: A Randomized, Double-blind, Placebo Controlled Study - A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia. - A Food Effect Study of TS-142 in Healthy Subjects - A Long Term Safety Study of Suvorexant in Participants With Primary Insomnia (MK-4305-009 AM3) - A Multicenter Observational Study of Lemborexant on Insomnia Patients With Psychiatric Disorders - A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Bayesian Adaptive Randomization Design, Dose Response Study of the Efficacy of E2006 in Adults and Elderly Subjects With Chronic Insomnia - A Pharmacokinetic Study of TS-142 in Patients with Hepatic Impairment - A Phase 1 Trial to Investigate the Biological Equivalence of 5 × 10 mg Tablets and 2 × 25 mg Tablets of Daridorexant in Healthy Male and Female Japanese Participants - A Phase I Study of TS-142 in Healthy Participants (Repeated Doses) - A Phase I Study of TS-142 in Healthy Participants (Single Doses) - A Pilot Study of Suvorexant for Insomnia in Parkinson Disease ### Drugs (8) - Almorexant Orexin receptor antagonist - Daridorexant Orexin receptor antagonist - Daridorexant hydrochloride Orexin receptor 1 antagonist - Filorexant Orexin receptor antagonist - Lemborexant Orexin receptor 1 antagonist - [Orn-0829 hydrate](https://trialight.com/data/asset/orn-0829-hydrate-92f99085-a773-43bb-b77b-07a441e66c94.md) Orexin receptor antagonist - SB-649868 Orexin receptor 1 antagonist - Suvorexant Orexin receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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